GlobalRPH

Menin Inhibitors in AML: Targeting KMT2A-Rearranged and NPM1-Mutated Disease

Oncology

by Nancy Ogbonna - July 31, 2026 0106

Menin Inhibitors in AML: Targeting KMT2A-Rearranged and NPM1-Mutated Disease Review Abstract Purpose Acute myeloid leukemia (AML) is a heterogeneous group of hematologic malignancies defined increasingly by recurrent molecular and cytogenetic abnormalities. KMT2A rearrangements and NPM1 mutations identify biologically distinct leukemias that frequently rely on menin-dependent

Prediabetes in 2026: Evidence Thresholds for Lifestyle Intervention, Metformin, and Anti-Obesity Pharmacotherapy

Endocrinology

by Nancy Ogbonna - July 31, 2026 0123

Prediabetes in 2026: Evidence Thresholds for Lifestyle Intervention, Metformin, and Anti-Obesity Pharmacotherapy Review Abstract Purpose This review examines when lifestyle intervention, metformin, and anti-obesity pharmacotherapy are most appropriate for adults with prediabetes. The objective is to clarify the role of each strategy using current clinical

Ultra-Low-Dose CT: How Low Can We Go Without Losing the Diagnosis?

by Nancy Ogbonna - July 31, 2026 094

Ultra-Low-Dose CT: How Low Can We Go Without Losing the Diagnosis? Review A Task-Based Review for Clinicians Abstract Purpose: This review examines the clinical role of ultra-low-dose computed tomography (ULDCT), with emphasis on the circumstances in which radiation reduction can preserve diagnostic performance and those

Urinary Tract Infection Is a Clinical Diagnosis: Avoiding Overdiagnosis From Asymptomatic Bacteriuria, Contamination, and Culture-Driven Treatment in Primary Care

by Nancy Ogbonna - July 31, 2026 076

Urinary Tract Infection Is a Clinical Diagnosis: Avoiding Overdiagnosis From Asymptomatic Bacteriuria, Contamination, and Culture-Driven Treatment in Primary Care Review Abstract Purpose Urinary tract infection is among the most frequently diagnosed bacterial infections in primary care and remains a major reason for outpatient antibiotic prescribing.

Vaginal Symptoms in Primary Care: A Test-Directed Approach to Candidiasis, Bacterial Vaginosis, and Trichomoniasis

Gynecology

by Nancy Ogbonna - July 31, 2026 070

Vaginal Symptoms in Primary Care: A Test-Directed Approach to Candidiasis, Bacterial Vaginosis, and Trichomoniasis Review Abstract Purpose Symptoms associated with vaginitis, including vaginal discharge, odor, pruritus, burning, irritation, dysuria, and dyspareunia, are common reasons for primary care, urgent care, gynecology, and sexual health visits. These

Fungal Infections in the ICU: Missed Disease, Colonization, and the Cost of Overcalling Candida

Infectious Disease

by Similoluwa Oluwalana - July 31, 2026 0453

Fungal Infections in the ICU: Missed Disease, Colonization, and the Cost of Overcalling Candida Review Abstract Purpose: This review examines the diagnostic and therapeutic challenges of fungal infections in the intensive care unit, with emphasis on distinguishing missed invasive disease from colonization, biomarker noise, and

Functional Neurological Disorder: From Diagnosis of Exclusion to Rule-In Neurology

Neurology

by Similoluwa Oluwalana - July 31, 2026 087

Functional Neurological Disorder: From Diagnosis of Exclusion to Rule-In Neurology Review Positive Signs, Diagnostic Safety, and Practical Treatment Pathways for Clinicians Abstract Purpose: This article reviews functional neurological disorder (FND) as a modern rule-in diagnosis, emphasizing positive clinical signs, diagnostic safety, clinician communication, functional seizures,

Cytokine Release Syndrome 2.0: Managing Immune-Effector Toxicity as Cell Therapy Moves Earlier, Broader, and Beyond CAR T

Oncology

by Similoluwa Oluwalana - July 31, 2026 0823

Cytokine Release Syndrome 2.0: Managing Immune-Effector Toxicity as Cell Therapy Moves Earlier, Broader, and Beyond CAR T Review Abstract Purpose: This article reviews cytokine release syndrome (CRS) and related immune-effector toxicities in the expanding era of cellular therapy, with emphasis on practical recognition, risk stratification,