Abrocitinib In The Treatment Of Moderate to Severe Atopic Dermatitis

Abrocitinib In The Treatment Of Moderate to Severe Atopic Dermatitis Overview This study examined the efficacy and safety of abrocitinib, a treatment for moderate-to-severe atopic dermatitis (AD), specifically focusing on patients with allergic comorbidities.   Data from phase 2b and phase 3 trials were analyzed, pooling information from patients who received abrocitinib or

Piclidenoson In The Treatment Of Plaque Psoriasis

Piclidenoson In The Treatment Of Plaque Psoriasis Overview The study focused on evaluating the effectiveness and safety of piclidenoson (CF101), an orally bioavailable agonist for the A3 adenosine receptor (A3AR), in treating moderate-to-severe plaque psoriasis. The A3AR is known to be overexpressed in the skin and peripheral blood mononuclear cells of individuals

Salbutamol: A Safety Meta-Analysis

Salbutamol: A Safety Meta-Analysis Overview Salbutamol, a widely used bronchospasm reliever, has been insufficiently scrutinized for potential risks. In a meta-analysis of 58 randomized controlled trials with 12,961 participants, the study unearthed a 34% incidence of total adverse events (AEs). Notably, severe AEs stood at 2%, and treatment discontinuation was 3%. Subgroup

Seizure Therapy And White Matter Changes

Seizure Therapy And White Matter Changes Functional seizures (FS) are a type of functional neurological symptom disorder that mimics epileptic seizures but lacks epileptiform changes on electroencephalography. The neuropathophysiology involves various brain systems, such as sensorimotor, emotion regulation, cognitive control, and multimodal integration.  Neurobehavioral therapy (NBT) has emerged as a viable treatment

Metronidazole For Vulval Crohn’s Disease Treatment

Metronidazole For Vulval Crohn's Disease Treatment Overview Cutaneous vulval Crohn's disease (VCD), an often overlooked extra-intestinal manifestation of Crohn's disease (CD), poses diagnostic and therapeutic challenges due to its potential for significant edema, painful fissures, and lasting disfigurement of the vulval anatomy. The lack of consensus on optimal management adds to the

Narcissistic Personality Disorder And Autism

Narcissistic Personality Disorder And Autism Overview This study explores the relationship between Autism Spectrum Disorders (ASD) and Narcissistic Personality Disorder (NPD), focusing on the dimensions of narcissistic vulnerability and grandiosity. Both ASD and NPD pose challenges in diagnosis due to shared characteristics, such as pervasive traits, lifelong duration, ego-syntonic features, and difficulties

Sleep Stage Moderation Using Automated Auditory Stimulation

Sleep Stage Moderation Using Automated Auditory Stimulation Overview The study introduces a pioneering protocol for the automated detection and suppression of slow-wave sleep (SWS), a crucial physiological process with implications for both basic science and clinical applications. The protocol involves the automated identification of SWS through the entire head topography of frontal

Myasthenia Gravis Therapeutic Benefits Of Monotherapy With Tacrolimus

Myasthenia Gravis Therapeutic Benefits Of Monotherapy With Tacrolimus Overview   In the management of mild to moderate myasthenia gravis (MG), the utilization of tacrolimus is typically reserved for cases that do not respond to glucocorticoids. This study sought to assess the potential advantages of mono-tacrolimus over mono-glucocorticoids in treating MG patients. The primary endpoint

Insomnia And Depression: Smartphone App Interventions

Insomnia And Depression: Smartphone App Interventions During adolescence, the prevalence of prevalent mental disorders, especially depression, increases at a faster rate among adolescents than among adults. Despite the critical need for intervention, many depressed adolescents go untreated due to barriers like stigma. This research explores an innovative approach targeting non-stigmatizing, self-identified

Ocrelizumab Effectiveness In Multiple Sclerosis

Ocrelizumab Effectiveness In Multiple Sclerosis Overview Throughout its clinical development program, ocrelizumab has consistently demonstrated efficacy in enhancing clinical outcomes for multiple sclerosis, encompassing annualized relapse rates and confirmed disability progression. Despite these positive findings, the translation of this efficacy into real-world clinical practice remained uncertain. This study aimed to systematically compile

Abrocitinib In The Treatment Of Moderate to Severe Atopic Dermatitis