Adult Sepsis Management in Internal Medicine: Are We Overtreating, Undertreating, or Targeting the Wrong Metrics? Review Abstract Background Management of adult sepsis requires prompt decision-making amid uncertainty about infection, organ dysfunction, hemodynamic status, and treatment responsiveness. Although standardized care pathways may reduce harmful delays, indiscriminate
Author: Similoluwa Oluwalana
Antibiotic Stewardship in Pediatrics: Optimizing Diagnosis, Drug Selection, and Treatment Duration
Antibiotic Stewardship in Pediatrics: Optimizing Diagnosis, Drug Selection, and Treatment Duration Review Abstract Background Pediatric antibiotic stewardship is not synonymous with reducing antibiotic use. It is the systematic effort to prescribe antibiotics only when necessary and, when treatment is indicated, to optimize antibiotic choice, dose,
ATR and WEE1 Inhibitors After PARP Resistance: Emerging DNA Damage Response Strategies Across Solid Tumors
ATR and WEE1 Inhibitors After PARP Resistance: Emerging DNA Damage Response Strategies Across Solid Tumors Review Abstract Background Resistance to poly(ADP-ribose) polymerase (PARP) inhibition has intensified interest in other components of the DNA damage response and replication-stress network. Early clinical studies have evaluated ataxia telangiectasia
BTK Degraders in CLL/SLL After BTK Inhibitor Failure: A Promising Escape Route Still Under Study
BTK Degraders in CLL/SLL After BTK Inhibitor Failure: A Promising Escape Route Still Under Study Review Abstract Purpose: This review assesses the rationale, emerging clinical evidence, safety considerations, and practical implications of Bruton tyrosine kinase (BTK) degraders in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), particularly after
AI Surgical Coaches: Do They Improve Outcomes, or Just Performance Metrics? What Early Real-World Data Show
AI Surgical Coaches: Do They Improve Outcomes, or Just Performance Metrics? What Early Real-World Data Show Review Abstract Purpose: This review examines the emerging evidence for artificial intelligence-assisted surgical coaching, with particular emphasis on whether these systems improve clinically meaningful outcomes or primarily improve technical-performance and
Can Bispecific Antibodies Move Safely Into the Outpatient Clinic? A Label-Concordant Framework for Clinicians
Can Bispecific Antibodies Move Safely Into the Outpatient Clinic? A Label-Concordant Framework for Clinicians Review Abstract Purpose: This review assesses whether CD3-engaging bispecific antibody therapy can be delivered safely in outpatient oncology settings, with emphasis on cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, infection prevention,
Fungal Infections in the ICU: Missed Disease, Colonization, and the Cost of Overcalling Candida
Fungal Infections in the ICU: Missed Disease, Colonization, and the Cost of Overcalling Candida Review Abstract Purpose: This review examines the diagnostic and therapeutic challenges of fungal infections in the intensive care unit, with emphasis on distinguishing missed invasive disease from colonization, biomarker noise, and
Functional Neurological Disorder: From Diagnosis of Exclusion to Rule-In Neurology
Functional Neurological Disorder: From Diagnosis of Exclusion to Rule-In Neurology Review Positive Signs, Diagnostic Safety, and Practical Treatment Pathways for Clinicians Abstract Purpose: This article reviews functional neurological disorder (FND) as a modern rule-in diagnosis, emphasizing positive clinical signs, diagnostic safety, clinician communication, functional seizures,
Cytokine Release Syndrome 2.0: Managing Immune-Effector Toxicity as Cell Therapy Moves Earlier, Broader, and Beyond CAR T
Cytokine Release Syndrome 2.0: Managing Immune-Effector Toxicity as Cell Therapy Moves Earlier, Broader, and Beyond CAR T Review Abstract Purpose: This article reviews cytokine release syndrome (CRS) and related immune-effector toxicities in the expanding era of cellular therapy, with emphasis on practical recognition, risk stratification,
Topical vs Systemic Therapy in Psoriasis: Escalating Wisely in the Biologic Era
Topical vs Systemic Therapy in Psoriasis: Escalating Wisely in the Biologic Era Review Abstract Purpose: This review examines how clinicians should decide among optimized topical therapy, phototherapy, oral systemic treatment, and biologic therapy in plaque psoriasis. Methodology: Review of recent clinical guidelines, FDA prescribing information,
