Evidence-based clinical review Caregiver Burden as a Hidden Vital Sign in Dementia Care: Why Routine Measurement Belongs in Geriatric Practice A brief, repeated measure can reveal risks that patient-only assessment misses, but screening should be linked to a defined clinical response. Estimated
Author: Similoluwa Oluwalana
Anesthesia for Robotic Pelvic Surgery: The Hidden Physiology of Steep Trendelenburg and Pneumoperitoneum
Intratumoral Immunotherapy and In-Situ Vaccination: Local Shots, Systemic Responses?
Adult Sepsis Management in Internal Medicine: Are We Overtreating, Undertreating, or Targeting the Wrong Metrics?
Adult Sepsis Management in Internal Medicine: Are We Overtreating, Undertreating, or Targeting the Wrong Metrics? Review Abstract Background Management of adult sepsis requires prompt decision-making amid uncertainty about infection, organ dysfunction, hemodynamic status, and treatment responsiveness. Although standardized care pathways may reduce harmful delays, indiscriminate
Antibiotic Stewardship in Pediatrics: Optimizing Diagnosis, Drug Selection, and Treatment Duration
Antibiotic Stewardship in Pediatrics: Optimizing Diagnosis, Drug Selection, and Treatment Duration Review Abstract Background Pediatric antibiotic stewardship is not synonymous with reducing antibiotic use. It is the systematic effort to prescribe antibiotics only when necessary and, when treatment is indicated, to optimize antibiotic choice, dose,
ATR and WEE1 Inhibitors After PARP Resistance: Emerging DNA Damage Response Strategies Across Solid Tumors
ATR and WEE1 Inhibitors After PARP Resistance: Emerging DNA Damage Response Strategies Across Solid Tumors Review Abstract Background Resistance to poly(ADP-ribose) polymerase (PARP) inhibition has intensified interest in other components of the DNA damage response and replication-stress network. Early clinical studies have evaluated ataxia telangiectasia
BTK Degraders in CLL/SLL After BTK Inhibitor Failure: A Promising Escape Route Still Under Study
BTK Degraders in CLL/SLL After BTK Inhibitor Failure: A Promising Escape Route Still Under Study Review Abstract Purpose: This review assesses the rationale, emerging clinical evidence, safety considerations, and practical implications of Bruton tyrosine kinase (BTK) degraders in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), particularly after
AI Surgical Coaches: Do They Improve Outcomes, or Just Performance Metrics? What Early Real-World Data Show
AI Surgical Coaches: Do They Improve Outcomes, or Just Performance Metrics? What Early Real-World Data Show Review Abstract Purpose: This review examines the emerging evidence for artificial intelligence-assisted surgical coaching, with particular emphasis on whether these systems improve clinically meaningful outcomes or primarily improve technical-performance and
Can Bispecific Antibodies Move Safely Into the Outpatient Clinic? A Label-Concordant Framework for Clinicians
Can Bispecific Antibodies Move Safely Into the Outpatient Clinic? A Label-Concordant Framework for Clinicians Review Abstract Purpose: This review assesses whether CD3-engaging bispecific antibody therapy can be delivered safely in outpatient oncology settings, with emphasis on cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, infection prevention,
Fungal Infections in the ICU: Missed Disease, Colonization, and the Cost of Overcalling Candida
Fungal Infections in the ICU: Missed Disease, Colonization, and the Cost of Overcalling Candida Review Abstract Purpose: This review examines the diagnostic and therapeutic challenges of fungal infections in the intensive care unit, with emphasis on distinguishing missed invasive disease from colonization, biomarker noise, and
