Bimekizumab Proves To Be A Highly Effective Therapy For Psoriatic Arthritis Patients Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting joints, skin, nails, and other tissues. Because it is long-term and can vary significantly between patients, ongoing treatment is needed. Biologic therapies like TNF inhibitors (TNFi) are often combined with
Internal Medicine
Neuropathy Progression Risk In Patients With Coagulation Abnormalities
Neuropathy Progression Risk In Patients With Coagulation Abnormalities Overview Nearly half of individuals with diabetes develop diabetic peripheral neuropathy (DPN), which is associated with a concerning 53% survival rate within three years. Coagulation abnormalities have been suggested to play a role in the pathogenesis of microvascular complications, including DPN. Therefore, investigating the
Gestational Diabetes Risk Smashed By Vitamin Supplementation
Gestational Diabetes Risk Smashed By Vitamin Supplementation Overview Exposure to heavy metals has been linked to an increased risk of developing gestational diabetes mellitus (GDM), potentially due to oxidative stress mechanisms. This study aimed to investigate whether vitamin C could influence the relationship between heavy metal exposure and the risk of GDM.
Oral Insulin Breakthroughs In Development
Oral Insulin Breakthroughs In Development INTRODUCTION Diabetes is a chronic metabolic disorder primarily classified into two types: type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). T1DM, an autoimmune disease often diagnosed in adolescence, is marked by the body's inability to produce insulin. In contrast, T2DM, which constitutes the majority
Attacking Heart Failure Inflammation With Prednisone
Prednisone’s Role in Combating Inflammation in Heart Failure Overview Steroid treatments, typically used for respiratory illnesses, could also help patients with acute heart failure (AHF) by addressing inflammation—a major factor in worsening outcomes. The CORTAHF trial investigated whether a short course of prednisone could lower inflammation and improve recovery in patients with
Stroke Victim Compliance With Prescription Medication
Stroke Victim Compliance With Prescription Medication Overview Adherence to secondary prevention medications following an ischemic stroke or transient ischemic attack is crucial for reducing recurrence risk. This study assessed medication adherence over a three-year period post-stroke using prescription and dispensing data, and aimed to identify factors influencing suboptimal adherence. Conducted as a multicenter,
Cardiac Arrest Wearable Detection Devices And Motivated Patient Compliance
Cardiac Arrest Wearable Detection Devices And Motivated Patient Compliance Overview When an out-of-hospital cardiac arrest (OHCA) occurs, the initial step in the chain of survival is early detection. However, 75% of OHCAs go unwitnessed, which creates a significant barrier to triggering the necessary life-saving interventions. Wearable devices have the potential to act
Surgical Success Of Crohn’s Disease Interventions
Surgical Success Of Crohn's Disease Interventions Overview Recent evidence questions the existing approach of reserving surgery for ileocaecal Crohn's disease (CD) patients only when complications arise. This study aimed to compare the short-term outcomes of patients who underwent primary ileocaecal resection for either an inflammatory phenotype (luminal disease, earlier in the disease
Tau Accumulation And White Matter Changes Linked To Hypertension
Tau Accumulation And White Matter Changes Linked To Hypertension Overview This study explored how amyloid buildup and hypertension interact to affect tau accumulation and atrophy in the entorhinal cortex (EC), while also investigating cerebral blood flow (CBF) as a potential shared mechanism. The researchers analyzed data from two cohorts of older adults
IBD Remission Communication To Promote Patient Comprehension
IBD Remission Communication To Promote Patient Comprehension Overview Previous research indicates that patients with inflammatory bowel disease (IBD) often have a different understanding of remission compared to healthcare professionals, which may impact their expectations and treatment outcomes. This study aimed to explore three key areas: (1) patients' current understanding of remission, (2)