Evidence-based clinical review Polypharmacy at the End of Life: Why Are So Many Patients Still Taking Statins and Bisphosphonates? A prognosis- and goals-based approach to preventive medications, with important exceptions for recent ASCVD, high fracture risk, and active cancer indications Estimated
Internal Medicine
Small Fiber Neuropathy: When EMG Is Normal but the Patient Is Not
Outpatient Community-Acquired Pneumonia in 2026: Are We Still Treating Too Broadly?
CIDP Overdiagnosis and IVIG Stewardship: Are We Treating the Right Patients for the Right Duration?
CIDP Overdiagnosis and IVIG Stewardship: Are We Treating the Right Patients for the Right Duration? Review Abstract Background Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a highly treatable immune-mediated neuropathy. However, establishing the diagnosis requires a careful integration of the clinical phenotype, electrodiagnostic findings, appropriate supportive evidence,
Frailty Before the ICU: Using Frailty Scores to Guide Escalation Without Turning Them Into Gatekeepers
Frailty Before the ICU: Using Frailty Scores to Guide Escalation Without Turning Them Into Gatekeepers Review Abstract Purpose: Frailty has emerged as an important predictor of adverse outcomes in hospitalized and critically ill adults, particularly among older patients with multiple chronic conditions. As healthcare systems increasingly care
Resistant Hypertension Gets Personal: Aldosterone, Renin, and the Renewed Secondary Workup
Resistant Hypertension Gets Personal: Aldosterone, Renin, and the Renewed Secondary Workup Review Abstract Purpose: Resistant hypertension remains a significant clinical challenge and is associated with a markedly increased risk of cardiovascular disease, chronic kidney disease progression, stroke, heart failure, and premature mortality. Despite the availability of multiple
Vestibular Migraine in Neurology Clinics: The Great Mimicker Behind Recurrent Vertigo
Vestibular Migraine in Neurology Clinics The Great Mimicker Behind Recurrent Vertigo Review Abstract Purpose: Vestibular migraine is increasingly recognized as one of the most common neurological causes of recurrent episodic vertigo and dizziness, yet it remains substantially underdiagnosed and frequently misclassified in routine clinical practice. Patients
GlobalRPh Vancomycin Dosing and Bayesian AUC Advanced Calculator
Introducing the GlobalRPh Vancomycin Dosing and Bayesian AUC Calculator Advanced (Beta) Five population models, conventional pharmacokinetics, Bayesian forecasting, and clinician-directed AUC dosing in one platform A formal introduction to the Advanced calculator's conventional AUC workflow, Bayesian mathematics, five population-specific models, model-selection safeguards, and clinician-directed
RSV Monoclonal Antibodies: A Paradigm Shift in Infant Protection
RSV Monoclonal Antibodies: A Paradigm Shift in Infant Protection Review Abstract Purpose: This review examines the evolving role of long-acting respiratory syncytial virus monoclonal antibodies in preventing RSV lower respiratory tract disease in infants and selected young children. Methodology: This article reviews current CDC and
Albuminuria as a Vital Sign: Why Urine ACR Is Becoming Central to Kidney-Cardiovascular Risk Assessment
Albuminuria as a Vital Sign: Why Urine ACR Is Becoming Central to Kidney-Cardiovascular Risk Assessment Review Abstract Albuminuria, most commonly assessed using the urine albumin-to-creatinine ratio (ACR), has emerged as one of the most valuable biomarkers in contemporary nephrology and cardiovascular medicine. Despite its proven clinical
