Evidence-based clinical review Prehospital Blood Products Determining Which EMS Units Should Carry Them Clinical Notes No, not every EMS unit should carry blood. The most defensible goal is reliable regional access to early transfusion. This is best achieved through selected assets that can maintain
Author: Nancy Ogbonna
Pharmacologic Management of Major Depressive Disorder in Primary Care: An Algorithm for Partial Response, Switching, and Augmentation
Is Isotretinoin Overregulated or Underused? Balancing Teratogenic Risk, Safety Evidence, and Access
Is Isotretinoin Overregulated or Underused Balancing Teratogenic Risk, Safety Evidence, and Access Review Abstract Background: Oral isotretinoin is strongly recommended for severe acne, acne causing scarring or major psychosocial burden, and disease that has not responded to standard topical or oral therapy. It is also a
Recurrent Pregnancy Loss: Evidence-Based Evaluation, Treatment, and Legacy Practices
The Neurology of Dysautonomia: POTS, Orthostatic Intolerance, and Autonomic Testing in 2026
Evidence-based clinical review The Neurology of Dysautonomia POTS, Orthostatic Intolerance, and Autonomic Testing in 2026 A Practical Neurologic Framework for Distinguishing POTS From Other Orthostatic Syndromes and Selecting Active Stand, Tilt-Table, Reflex, Sudomotor, and Small-Fiber Studies Estimated reading time: 15 minutes
Shorter Antibiotic Courses: How Short Is Too Short?
Thrombolysis in Intermediate-Risk Pulmonary Embolism: Who Should Receive Early Reperfusion?
Thrombolysis in Intermediate-Risk Pulmonary Embolism Who Should Receive Early Reperfusion Review Abstract Background Intermediate-risk pulmonary embolism sits in a genuinely difficult therapeutic space. On one side, you have uncomplicated pulmonary embolism managed primarily with anticoagulation. On the other side, pulmonary embolism complicated by cardiopulmonary failure that demands urgent
Subclinical Thyroid Dysfunction in Family Practice: Evidence, Treatment Thresholds, and Counseling for Patient-Requested Testing
Subclinical Thyroid Dysfunction in Family Practice: Evidence, Treatment Thresholds, and Counseling for Patient-Requested Testing Review Abstract Background Subclinical thyroid dysfunction is defined by biochemistry rather than symptoms. Subclinical hypothyroidism presents as an elevated thyroid-stimulating hormone (TSH) level with a free thyroxine (FT4) level that remains within the
Same-Day Total Hip and Knee Arthroplasty: The Anesthesiologist’s Expanding Role in Ambulatory ERAS
Same-Day Total Hip and Knee Arthroplasty: The Anesthesiologist's Expanding Role in Ambulatory ERAS Review Abstract Background Same-day discharge following elective primary total hip arthroplasty (THA) and total knee arthroplasty (TKA) has become a well-established component of modern orthopedic care. Successful implementation relies on appropriate patient selection, rapid-recovery pathways, multidisciplinary
Skin Cancer Detection and Procedural Decisions in Family Practice: When to Biopsy, Use Cryotherapy, or Refer
Skin Cancer Detection and Procedural Decisions in Family Practice: When to Biopsy, Use Cryotherapy, or Refer Review Abstract Background Evaluation of an identified suspicious skin lesion is fundamentally distinct from routine skin cancer screening. The U.S. Preventive Services Task Force (USPSTF) concludes that evidence is insufficient to
