Obesity, Metabolic Syndrome, and ‘Difficult-to-Treat’ Psoriatic Arthritis Is Inflammation Only Half the Story Review Abstract Psoriatic arthritis (PsA) is a chronic, immune mediated inflammatory musculoskeletal disease that affects a substantial proportion of individuals with psoriasis. Characterized by peripheral arthritis, enthesitis, dactylitis, axial involvement, and progressive joint damage, PsA is associated
Gastroenterology
Ozempic Nation: Paradigm Shift or Public Health Mirage?
Ozempic Nation Paradigm Shift or Public Health Mirage Review Abstract The emergence of glucagon-like peptide-1 (GLP-1) receptor agonists and related incretin-based therapies has transformed the management of obesity and type 2 diabetes mellitus. Semaglutide, marketed as Ozempic for diabetes and Wegovy for obesity, initiated a major shift in
IBS Next-Generation Therapies: Low FODMAP Diets, Neuromodulators, Digital Cognitive Behavioral Therapy, and Microbiome-Based Interventions
IBS Next-Generation Therapies: Low FODMAP Diets, Neuromodulators, Digital Cognitive Behavioral Therapy, and Microbiome-Based Interventions Review Abstract Background Irritable bowel syndrome (IBS) is a chronic disorder of gut–brain interaction characterized by abdominal pain associated with altered bowel habits. Conventional therapies often provide incomplete symptom relief, leading to
Post-Polypectomy Surveillance: Are We Over-Scoping Patients (and Under-Scoping the High-Risk Ones)?
Post-Polypectomy Surveillance: Are We Over-Scoping Patients (and Under-Scoping the High-Risk Ones)? Review Key Takeaways Post polypectomy surveillance is a critical component of colorectal cancer prevention strategies, aimed at reducing the incidence of interval colorectal cancers through timely follow up colonoscopy after adenoma removal. However, current surveillance practices
Microbiome Therapeutics After Recurrent C. diff: What’s Real, What’s Hype, and What’s Next?
Microbiome Therapeutics After Recurrent C. diff What’s Real, What’s Hype, and What’s Next Review Abstract Recurrent Clostridioides difficile infection (rCDI) remains a significant and persistent challenge in clinical practice, occurring in approximately 20 to 30 percent of patients after an initial episode. The risk of recurrence increases with
AI in the Endoscopy Suite: Adenoma Detection Booster or Expensive Distraction?
AI in the Endoscopy Suite Adenoma Detection Booster or Expensive Distraction Review Abstract Artificial intelligence systems designed for adenoma detection during colonoscopy represent a remarkable advancement in gastrointestinal endoscopy and colorectal cancer prevention. Colonoscopy remains the gold standard for colorectal cancer screening, yet its effectiveness is highly operator
From NAFLD to MASLD: Does the New Nomenclature Actually Change Care?
From NAFLD to MASLD Does the New Nomenclature Actually Change Care Review Abstract The transition from non alcoholic fatty liver disease to metabolic dysfunction associated steatotic liver disease represents a significant conceptual evolution in hepatology rather than a purely semantic change. Endorsed by major international
Antibiotics for H. pylori: Why First-Line Treatment Fails and What Salvage Regimens Actually Work
Antibiotics for H. pylori: Why First-Line Treatment Fails and What Salvage Regimens Actually Work Key Takeaways pylori treatment has evolved dramatically due to rising antibiotic resistance, requiring physicians to abandon traditional approaches and adopt resistance-resilient strategies from the start. Bismuth quadruple therapy
The Microbiome and Metabolism: Can Gut Flora Be the Next Endocrine Organ?
The Microbiome and Metabolism: Can Gut Flora Be the Next Endocrine Organ? Abstract The human gut microbiome has increasingly been recognized as a central determinant of metabolic health, with growing evidence suggesting that it functions not merely as a collection of commensal microorganisms but as a
Obesity as Chronic Disease: Building a Follow-up Model Like HTN/A1c
Obesity as Chronic Disease Building a Follow-up Model Like HTNA1c Abstract Obesity is increasingly recognized as a chronic, relapsing, multifactorial disease that requires long term clinical management rather than episodic intervention. Its pathophysiology involves complex interactions among genetic predisposition, neuroendocrine regulation, metabolic adaptation, environmental
