Type 2 Diabetes Mellitus: Cellular Mechanisms, Reductionist Pitfalls, and Evidence-Based Prevention

Type 2 Diabetes Mellitus as a Multifactorial Cardiometabolic Disease: Cellular Mechanisms, Reductionist Pitfalls, and Evidence-Based Prevention Narrative Review Abstract Type 2 diabetes mellitus (T2DM) is a progressive, heterogeneous, multi-organ metabolic disease characterized by chronic hyperglycemia arising from inadequate insulin secretion relative to metabolic demand, usually

Resistant Starch and Short-Chain Fatty Acids: A Comprehensive Review of Physiologic Mechanisms

Resistant Starch and Short-Chain Fatty Acids: A Comprehensive Review of Physiologic Mechanisms and Clinical Relevance Comprehensive Guide   Abstract Resistant starch represents a distinct category of dietary carbohydrate that escapes digestion in the small intestine and undergoes fermentation by colonic bacteria. This process generates short-chain fatty

Glucagon-Like Peptide-1 Receptor Agonists and Human Fertility

Glucagon-Like Peptide-1 Receptor Agonists and Human Fertility: Mechanisms, Evidence, and Clinical Implications Abstract Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are well established for the treatment of type 2 diabetes mellitus and obesity. Increasingly, reports suggest a possible association between GLP-1 RA use and

Insulin Resistance Used To Assess Malignancies In Women

Insulin Resistance Used To Assess Malignancies In Women Overview In this prospective multicenter real-world cohort study involving 571 patients diagnosed with female reproductive system malignancies, the prognostic significance of insulin resistance (IR) and systemic inflammation was investigated. The cohort, with a mean age of 52 years, predominantly comprised individuals with cervical cancer

From NAFLD to MASLD: Does the New Nomenclature Actually Change Care?