Type 2 Diabetes Mellitus as a Multifactorial Cardiometabolic Disease: Cellular Mechanisms, Reductionist Pitfalls, and Evidence-Based Prevention Narrative Review Abstract Type 2 diabetes mellitus (T2DM) is a progressive, heterogeneous, multi-organ metabolic disease characterized by chronic hyperglycemia arising from inadequate insulin secretion relative to metabolic demand, usually
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Understanding Subclinical Hypothyroidism: The Essential Guide to Borderline Thyroid Test Results
Understanding Subclinical Hypothyroidism: The Essential Guide to Borderline Thyroid Test Results Introduction Subclinical hypothyroidism is one of the most frequently encountered biochemical thyroid abnormalities in clinical practice, affecting approximately 5 percent of adults in the United States. Its prevalence increases substantially with age and is
Cefepime Neurotoxicity: Underrecognized Risk or Overblown Concern?
Cefepime Neurotoxicity Underrecognized Risk or Overblown Concern Abstract Cefepime is a fourth generation cephalosporin antibiotic that is widely utilized in clinical practice for the treatment of severe and life threatening bacterial infections, including hospital acquired pneumonia, febrile neutropenia, complicated urinary tract infections, and infections caused by
Preventing the Next Pandemic: Critical Insights from SARS-CoV-2 Surveillance Systems
Preventing the Next Pandemic Critical Insights from SARS-CoV-2 Surveillance Systems Introduction Preventing the next global pandemic requires a clear understanding of the profound and multifaceted impact of SARS-CoV-2, the virus responsible for COVID-19. Since its emergence, SARS-CoV-2 has infected millions of people worldwide and caused
Silent Inflammation: The Hidden Driver of Multisystem Chronic Disease?
Silent Inflammation The Hidden Driver of Multisystem Chronic Disease Abstract Chronic low grade inflammation, often referred to as silent inflammation, is increasingly recognized as a persistent inflammatory state that occurs in the absence of the classical signs and symptoms associated with acute inflammation.
Rare Disease Diagnosis: The Promise of Whole-Genome Sequencing in Pediatrics
Rare Disease Diagnosis The Promise of Whole-Genome Sequencing in Pediatrics Abstract Rare diseases collectively affect millions of children worldwide and represent a significant source of morbidity, mortality, and long term disability. Although individual rare disorders have low prevalence, their cumulative impact places a substantial
Biological vs Chronological Age: Are Geriatricians Ready for ‘Aging Clocks’?
Biological vs Chronological Age: Are Geriatricians Ready for ‘Aging Clocks’? Abstract The concept of biological age versus chronological age represents a fundamental shift in how healthcare providers assess aging and age-related health risks. While chronological age measures the time elapsed since birth, biological
Skyrocketing Cancer Drug Prices: Can Oncologists Influence Policy?
Skyrocketing Cancer Drug Prices Can Oncologists Influence Policy Abstract The rapid escalation of cancer drug prices has emerged as a major challenge in contemporary oncology practice, with many newly approved therapies carrying annual costs that exceed one hundred thousand dollars per patient. This
The Endocrine Disruptor Epidemic: What Should Clinicians Be Telling Patients?
The Endocrine Disruptor Epidemic: What Should Clinicians Be Telling Patients? Abstract Endocrine disrupting chemicals represent a growing public health concern that requires heightened awareness and engagement from healthcare professionals across disciplines. These substances, which include both synthetic and naturally occurring compounds, have the capacity
AI Risk Scores vs HEART Score: Which Better Predicts Chest Pain Outcomes?
