The Death (or Rebirth) of Aspirin in Primary Prevention Abstract The role of aspirin in primary prevention of cardiovascular disease has undergone substantial reassessment over the past decade as emerging evidence has challenged long standing assumptions regarding its routine use in individuals without established cardiovascular disease. For many
Cardiology
Obesity as Chronic Disease: Building a Follow-up Model Like HTN/A1c
Obesity as Chronic Disease Building a Follow-up Model Like HTNA1c Abstract Obesity is increasingly recognized as a chronic, relapsing, multifactorial disease that requires long term clinical management rather than episodic intervention. Its pathophysiology involves complex interactions among genetic predisposition, neuroendocrine regulation, metabolic adaptation, environmental
Hypotension Prediction Index and Machine Learning: Game Changer or Gimmick?
Hypotension Prediction Index and Machine Learning Game Changer or Gimmick Abstract Intraoperative and critical care hypotension is independently associated with adverse outcomes, including acute kidney injury, myocardial injury, stroke, prolonged hospitalization, and increased mortality. Even brief episodes of mean arterial pressure below established thresholds have been
Why GLP-1 Receptor Agonists Are Becoming Essential Cardiovascular Drugs
Why GLP-1 Receptor Agonists Are Becoming Essential Cardiovascular Drugs Introduction Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as a transformative class of medications in the management of type 2 diabetes, demonstrating an approximate 14 percent reduction in major adverse cardiovascular events. Initially developed
Beyond Thrombectomy: Latest Advances in Large Vessel Occlusion Therapy
Beyond Thrombectomy: Latest Advances in Large Vessel Occlusion Therapy Introduction Stroke from large vessel occlusion remains a devastating neurological emergency affecting millions worldwide. According to the American Heart Association, stroke ranks as the fourth leading cause of death in the United States, with
AI in the Cath Lab: Clinical Breakthrough or Expensive Decision Support?
AI in the Cath Lab: Clinical Breakthrough or Expensive Decision Support? Abstract The integration of artificial intelligence (AI) into cardiac catheterization laboratories represents a major shift in cardiovascular medicine. This analysis examines the clinical effectiveness, economic impact, and practical implementation of AI systems
LDL Targets Below 40 mg/dL: How Low Is Too Low in 2026?
Beyond Thresholds: Why Continuous Risk Assessment Improves Hypertension Treatment
Beyond Thresholds: Why Continuous Risk Assessment Improves Hypertension Treatment Introduction Hypertension treatment based solely on blood pressure thresholds may miss critical opportunities to prevent cardiovascular disease. For decades, physicians have relied on the 140/90 mm Hg cutoff to determine which patients require pharmacological
Coronary Artery Calcium–Guided Prevention and Microbiome-Centered Nutrition
Coronary Artery Calcium–Guided Prevention and Microbiome-Centered Nutrition: A Physician-Focused Review Integrating the Clinical Framework of William Davis, MD Quick Summary CAC is most useful when you’re on the fence. In borderline/intermediate-risk patients—or when risk markers conflict—CAC can clarify preventive intensity and improve
Expert Guide: Managing Cardiovascular-Kidney-Metabolic Syndrome in Clinical Practice
Expert Guide Managing Cardiovascular-Kidney-Metabolic Syndrome in Clinical Practice Introduction Cardiovascular kidney metabolic syndrome represents one of the most urgent and complex health challenges of the modern era. The global burden of cardiovascular disease continues to rise at an alarming pace, with prevalence increasing from approximately
