Neuromodulation for Depression and Chronic Pain: Beyond Deep Brain Stimulation Review Abstract Neuromodulation therapies have become increasingly important in the management of treatment resistant depression and chronic pain, two conditions that continue to impose substantial personal, societal, and economic burdens worldwide. Despite significant advances in pharmacologic and psychotherapeutic interventions,
Neurology
Plasma Biomarkers for Neurodegenerative Disease: What Clinicians Need to Know in 2026
Plasma Biomarkers for Neurodegenerative Disease What Clinicians Need to Know in 2026 Review Key Takeaways Plasma biomarkers are rapidly transforming the diagnosis and management of Alzheimer’s disease and related dementias, representing one of the most notable advances in neurodegenerative medicine in recent decades. Historically, the definitive assessment of Alzheimer’s pathology has
How to Define Analgesia and Implement Safe Opioid Therapy Protocols in Family Medicine
How to Define Analgesia and Implement Safe Opioid Therapy Protocols in Family Medicine Review Key Takeaways Family physicians occupy a central position in the management of acute and chronic pain, making safe opioid prescribing a critical component of primary care practice. As opioid related morbidity and mortality
The New Face of Delirium: Sedative Stewardship, Antipsychotic Backlash, and Non-Pharmacologic Protocols
The New Face of Delirium Sedative Stewardship, Antipsychotic Backlash, and Non-Pharmacologic Protocols Review Abstract Purpose:This review examines the evolving landscape of delirium management in contemporary clinical practice, with particular emphasis on three interconnected areas that are reshaping patient care: the implementation of sedative stewardship programs, increasing concerns
Cerebral Small Vessel Disease: The Hidden Driver of Cognitive Decline
Cerebral Small Vessel Disease: The Hidden Driver of Cognitive Decline Review Abstract Cerebral small vessel disease (CSVD) represents one of the most common yet underrecognized causes of cognitive impairment and functional decline worldwide. The condition affects the brain’s smallest blood vessels and leads to a
Insomnia in Primary Care: Implementation of CBT
Insomnia in Primary Care: Implementation of CBT Review Abstract Insomnia is one of the most prevalent sleep disorders encountered in primary care and affects approximately 10–15% of adults worldwide. Chronic insomnia is associated with substantial impairments in daytime functioning, increased healthcare utilization, psychiatric and medical comorbidity, and reduced
MS Phenotypes: Why the Current Classification System May Be Failing Patients
MS Phenotypes: Why the Current Classification System May Be Failing Patients Review Key Takeaways The traditional classification system for multiple sclerosis, established in 1996 by the United States National Multiple Sclerosis Society, continues to shape clinical practice, therapeutic decision making, and clinical trial design nearly three
The Ethics of Neural Enhancement: Where Does Therapeutic End and Augmentation Begin?
The Ethics of Neural Enhancement: Where Does Therapeutic End and Augmentation Begin? Review Abstract Neural enhancement technologies represent one of the most complex and consequential ethical challenges in contemporary medicine. As advances in neuroscience and biomedical engineering accelerate, the distinction between treating neurological disease and enhancing
Non Narcotic Pain Medication: Evidence-Based Strategies for Chronic Pain Management in Primary Care
Non Narcotic Pain Medication Evidence-Based Strategies for Chronic Pain Management in Primary Care Review Key Takeaways Chronic pain remains one of the most prevalent and challenging conditions encountered in primary care, affecting approximately one in five adults in the United States. It is associated with substantial
AI-Driven Prognostic Models in Traumatic Brain Injury
AI-Driven Prognostic Models in Traumatic Brain Injury Abstract Traumatic brain injury remains one of the most significant contributors to mortality and long term disability worldwide, affecting individuals across all age groups and placing a substantial burden on healthcare systems. It is a major cause of death
