The Glucagon Paradox in Next-Generation Incretin Therapy: How GLP-1, GIP, and Glucagon Receptor Co-Agonism May Amplify Weight Loss Despite Glucagon’s Hyperglycemic Biology D. Mcauley Abstract The development of dual and triple incretin-based receptor agonists represents a major advance in the pharmacologic treatment of obesity, type
Neuromodulation for Depression and Chronic Pain: Beyond Deep Brain Stimulation
Neuromodulation for Depression and Chronic Pain: Beyond Deep Brain Stimulation Review Abstract Neuromodulation therapies have become increasingly important in the management of treatment resistant depression and chronic pain, two conditions that continue to impose substantial personal, societal, and economic burdens worldwide. Despite significant advances in pharmacologic and psychotherapeutic interventions,
Obesity, Metabolic Syndrome, and ‘Difficult-to-Treat’ Psoriatic Arthritis: Is Inflammation Only Half the Story?
Obesity, Metabolic Syndrome, and ‘Difficult-to-Treat’ Psoriatic Arthritis Is Inflammation Only Half the Story Review Abstract Psoriatic arthritis (PsA) is a chronic, immune mediated inflammatory musculoskeletal disease that affects a substantial proportion of individuals with psoriasis. Characterized by peripheral arthritis, enthesitis, dactylitis, axial involvement, and progressive joint damage, PsA is associated
Plasma Biomarkers for Neurodegenerative Disease: What Clinicians Need to Know in 2026
Plasma Biomarkers for Neurodegenerative Disease What Clinicians Need to Know in 2026 Review Key Takeaways Plasma biomarkers are rapidly transforming the diagnosis and management of Alzheimer’s disease and related dementias, representing one of the most notable advances in neurodegenerative medicine in recent decades. Historically, the definitive assessment of Alzheimer’s pathology has
Revolutionizing Diabetes Monitoring: Beyond A1C to Continuous Metabolic Profiling
Revolutionizing Diabetes Monitoring Beyond A1C to Continuous Metabolic Profiling Review Abstract Diabetes mellitus remains one of the most prevalent and challenging chronic diseases worldwide, affecting hundreds of millions of individuals and contributing significantly to cardiovascular disease, kidney failure, blindness, neuropathy, and premature mortality. Effective diabetes management
How to Define Analgesia and Implement Safe Opioid Therapy Protocols in Family Medicine
How to Define Analgesia and Implement Safe Opioid Therapy Protocols in Family Medicine Review Key Takeaways Family physicians occupy a central position in the management of acute and chronic pain, making safe opioid prescribing a critical component of primary care practice. As opioid related morbidity and mortality
The New Face of Delirium: Sedative Stewardship, Antipsychotic Backlash, and Non-Pharmacologic Protocols
The New Face of Delirium Sedative Stewardship, Antipsychotic Backlash, and Non-Pharmacologic Protocols Review Abstract Purpose:This review examines the evolving landscape of delirium management in contemporary clinical practice, with particular emphasis on three interconnected areas that are reshaping patient care: the implementation of sedative stewardship programs, increasing concerns
AI in Pediatric Radiology: Can Algorithms Outperform Human Readers in Detecting Childhood Disease?
AI in Pediatric Radiology: Can Algorithms Outperform Human Readers in Detecting Childhood Disease? Review Abstract The integration of artificial intelligence (AI) into pediatric radiology represents a transformative shift in medical imaging practice. This review examines current evidence regarding AI performance compared to human radiologists in
Energy Devices Under the Microscope: Are We Underestimating Thermal Injury?
Energy Devices Under the Microscope: Are We Underestimating Thermal Injury? Review Abstract Purpose: To examine current understanding of thermal injury mechanisms in energy-based medical devices and assess whether healthcare providers adequately recognize risk factors, injury patterns, and prevention strategies. Methodology: Analysis of current literature, clinical case studies,
Abnormal Uterine Bleeding: When to Stop ‘Try Another Pill’ and Go Procedural
Abnormal Uterine Bleeding: When to Stop 'Try Another Pill' and Go Procedural Review Abstract Abnormal uterine bleeding affects up to 30% of reproductive-age women and represents a major healthcare burden. While hormonal contraceptives remain first-line therapy, practitioners often cycle through multiple formulations without clear endpoints.
