Insulin Resistance in Non-Obese Patients: The "Metabolically Obese Normal Weight” Paradox Review Abstract Normal body mass index (BMI) has long been used as a convenient and widely accepted screening tool for assessing overweight, obesity, and cardiometabolic risk. Although BMI remains valuable for population level surveillance and initial clinical
Tag: metabolic health
Pediatric Obesity and GLP-1 Agonists: Are We Ready for Pharmacologic Therapy in Children?
Pediatric Obesity and GLP-1 Agonists Are We Ready for Pharmacologic Therapy in Children Review Abstract Pediatric obesity has emerged as one of the most important public health challenges of the twenty-first century. Once viewed primarily as a consequence of lifestyle choices, obesity is now widely recognized
Ozempic Nation: Paradigm Shift or Public Health Mirage?
Ozempic Nation Paradigm Shift or Public Health Mirage Review Abstract The emergence of glucagon-like peptide-1 (GLP-1) receptor agonists and related incretin-based therapies has transformed the management of obesity and type 2 diabetes mellitus. Semaglutide, marketed as Ozempic for diabetes and Wegovy for obesity, initiated a major shift in
Type 2 Diabetes Mellitus: Cellular Mechanisms, Reductionist Pitfalls, and Evidence-Based Prevention
Type 2 Diabetes Mellitus as a Multifactorial Cardiometabolic Disease: Cellular Mechanisms, Reductionist Pitfalls, and Evidence-Based Prevention Narrative Review Abstract Type 2 diabetes mellitus (T2DM) is a progressive, heterogeneous, multi-organ metabolic disease characterized by chronic hyperglycemia arising from inadequate insulin secretion relative to metabolic demand, usually
The Microbiome and Metabolism: Can Gut Flora Be the Next Endocrine Organ?
The Microbiome and Metabolism: Can Gut Flora Be the Next Endocrine Organ? Abstract The human gut microbiome has increasingly been recognized as a central determinant of metabolic health, with growing evidence suggesting that it functions not merely as a collection of commensal microorganisms but as a
Resistant Starch and Short-Chain Fatty Acids: A Comprehensive Review of Physiologic Mechanisms
Resistant Starch and Short-Chain Fatty Acids: A Comprehensive Review of Physiologic Mechanisms and Clinical Relevance Comprehensive Guide Abstract Resistant starch represents a distinct category of dietary carbohydrate that escapes digestion in the small intestine and undergoes fermentation by colonic bacteria. This process generates short-chain fatty
Mind, Body & Immunity: 60 Psychological Insights Into How Mental Health Influences Physical Health
Mind, Body & Immunity: 60 Psychological Insights Into How Mental Health Influences Physical Health Abstract This paper examines the relationship between psychological states and physical health outcomes through an analysis of 60 evidence-based insights. The research draws from current studies in psychoneuroimmunology, behavioral
GLP-1 Agonists for Obesity in Non-Diabetic Patients: Game Changer or Overhyped? A Critical Analysis
Dietary Strategies for AMPK Activation, mTOR Suppression, and Longevity Enhancement
mTOR and Longevity: Rethinking the Role of Periodic Nutrient Stimulation
