The Cervical Screening Shake-Up: Primary HPV Testing, Genotyping, and Real-World Confusion Review Abstract The transition from cytology-centered cervical cancer screening to primary high-risk human papillomavirus testing represents one of the most important changes in preventive gynecologic care. Primary HPV testing is more sensitive than cytology
Family Practice Medicine
Nail Disorders as Clues to Systemic Disease: Evidence, Limitations, and Diagnostic Value in Clinical Practice
Nail Disorders as Clues to Systemic Disease: Evidence, Limitations, and Diagnostic Value in Clinical Practice Review Abstract The physical examination remains a cornerstone of clinical medicine, yet certain components are frequently overlooked despite their diagnostic value. Among these, examination of the nail unit represents a
The Glucagon Paradox in Next-Generation Incretin Therapy: GLP-1, GIP, and Glucagon Receptor Co-Agonism
The Glucagon Paradox in Next-Generation Incretin Therapy: How GLP-1, GIP, and Glucagon Receptor Co-Agonism May Amplify Weight Loss Despite Glucagon’s Hyperglycemic Biology D. Mcauley Abstract The development of dual and triple incretin-based receptor agonists represents a major advance in the pharmacologic treatment of obesity, type
Obesity, Metabolic Syndrome, and ‘Difficult-to-Treat’ Psoriatic Arthritis: Is Inflammation Only Half the Story?
Obesity, Metabolic Syndrome, and ‘Difficult-to-Treat’ Psoriatic Arthritis Is Inflammation Only Half the Story Review Abstract Psoriatic arthritis (PsA) is a chronic, immune mediated inflammatory musculoskeletal disease that affects a substantial proportion of individuals with psoriasis. Characterized by peripheral arthritis, enthesitis, dactylitis, axial involvement, and progressive joint damage, PsA is associated
How to Define Analgesia and Implement Safe Opioid Therapy Protocols in Family Medicine
How to Define Analgesia and Implement Safe Opioid Therapy Protocols in Family Medicine Review Key Takeaways Family physicians occupy a central position in the management of acute and chronic pain, making safe opioid prescribing a critical component of primary care practice. As opioid related morbidity and mortality
Reimagining Code Status in the 80+ Population: Beyond ‘Full Code’ vs ‘DNR.’
Reimagining Code Status in the 80+ Population: Beyond ‘Full Code’ vs ‘DNR.’ Review Abstract The traditional binary approach to code status decisions in patients over 80 years old fails to address the complex medical and ethical considerations inherent in this vulnerable population. This paper examines
Ozempic Nation: Paradigm Shift or Public Health Mirage?
Ozempic Nation Paradigm Shift or Public Health Mirage Review Abstract The emergence of glucagon-like peptide-1 (GLP-1) receptor agonists and related incretin-based therapies has transformed the management of obesity and type 2 diabetes mellitus. Semaglutide, marketed as Ozempic for diabetes and Wegovy for obesity, initiated a major shift in
Contemporary Lipid Management in Family Practice: Risk Stratification, Coronary Artery Calcium, and Shared Decision-Making for Statin Therapy
Contemporary Lipid Management in Family Practice: Risk Stratification, Coronary Artery Calcium, and Shared Decision-Making for Statin Therapy Review Abstract Purpose: This paper examines current approaches to lipid management in family practice, focusing on risk stratification methods, the role of coronary artery calcium scoring, and implementation of
The Rise of Precision Lipidology: Beyond LDL-C to ApoB, Lp(a), and Atherogenic Particle Burden
The Rise of Precision Lipidology: Beyond LDL-C to ApoB, Lp(a), and Atherogenic Particle Burden Review Abstract Lipidology is undergoing a clinically important transition from traditional cholesterol-centered assessment toward a more precise evaluation of atherogenic lipoprotein burden. Low-density lipoprotein cholesterol (LDL-C) remains a validated therapeutic target
Iron Deficiency Without Anemia: Fatigue Workup That Leads to Actionable Fixes
Iron Deficiency Without Anemia Fatigue Workup That Leads to Actionable Fixes Review Abstract Iron deficiency without anemia (IDWA) is a prevalent yet frequently underrecognized condition in clinical practice that can greatly impair patient well being and functional capacity. It is particularly common among women of reproductive
