Evidence-based clinical review Cushing Disease in 2026 Updated Diagnostic Algorithms and Targeted Therapies A practical clinician guide to confirming hypercortisolism, localizing an ACTH source, and selecting surgery or medical therapy Abstract Background Cushing disease is pituitary adrenocorticotropic
Endocrinology
Continuous Glucose Monitoring Beyond Insulin: Evidence, OTC Systems, and Data Interpretation for Family Medicine
Evidence-based clinical review Continuous Glucose Monitoring Beyond Insulin Evidence, OTC Systems, and Data Interpretation for Family Medicine A practical framework for selecting professional, prescription, or over-the-counter CGM and converting an ambulatory glucose profile into safe clinical decisions Estimated reading time: 15 minutes
Subclinical Thyroid Dysfunction in Family Practice: Evidence, Treatment Thresholds, and Counseling for Patient-Requested Testing
Subclinical Thyroid Dysfunction in Family Practice: Evidence, Treatment Thresholds, and Counseling for Patient-Requested Testing Review Abstract Background Subclinical thyroid dysfunction is defined by biochemistry rather than symptoms. Subclinical hypothyroidism presents as an elevated thyroid-stimulating hormone (TSH) level with a free thyroxine (FT4) level that remains within the
Prediabetes in 2026: Evidence Thresholds for Lifestyle Intervention, Metformin, and Anti-Obesity Pharmacotherapy
Prediabetes in 2026: Evidence Thresholds for Lifestyle Intervention, Metformin, and Anti-Obesity Pharmacotherapy Review Abstract Purpose This review examines when lifestyle intervention, metformin, and anti-obesity pharmacotherapy are most appropriate for adults with prediabetes. The objective is to clarify the role of each strategy using current clinical
Insulin Resistance in Non-Obese Patients: The “Metabolically Obese Normal Weight” Paradox
Insulin Resistance in Non-Obese Patients: The "Metabolically Obese Normal Weight” Paradox Review Abstract Normal body mass index (BMI) has long been used as a convenient and widely accepted screening tool for assessing overweight, obesity, and cardiometabolic risk. Although BMI remains valuable for population level surveillance and initial clinical
Pediatric Obesity and GLP-1 Agonists: Are We Ready for Pharmacologic Therapy in Children?
Pediatric Obesity and GLP-1 Agonists Are We Ready for Pharmacologic Therapy in Children Review Abstract Pediatric obesity has emerged as one of the most important public health challenges of the twenty-first century. Once viewed primarily as a consequence of lifestyle choices, obesity is now widely recognized
Perimenopause vs Thyroid vs Mood: Sorting Symptom Overlap Efficiently
Perimenopause vs Thyroid vs Mood Sorting Symptom Overlap Efficiently Review Abstract Perimenopause, thyroid dysfunction, depression, and anxiety represent some of the most common and diagnostically challenging conditions encountered in midlife clinical practice. These disorders frequently coexist and share a broad range of overlapping symptoms, creating major complexity
Revolutionizing Diabetes Monitoring: Beyond A1C to Continuous Metabolic Profiling
Revolutionizing Diabetes Monitoring Beyond A1C to Continuous Metabolic Profiling Review Abstract Diabetes mellitus remains one of the most prevalent and challenging chronic diseases worldwide, affecting hundreds of millions of individuals and contributing significantly to cardiovascular disease, kidney failure, blindness, neuropathy, and premature mortality. Effective diabetes management
Ozempic Nation: Paradigm Shift or Public Health Mirage?
Ozempic Nation Paradigm Shift or Public Health Mirage Review Abstract The emergence of glucagon-like peptide-1 (GLP-1) receptor agonists and related incretin-based therapies has transformed the management of obesity and type 2 diabetes mellitus. Semaglutide, marketed as Ozempic for diabetes and Wegovy for obesity, initiated a major shift in
What a Closed Loop System for Insulin Delivery Contains: Breaking Down Artificial Pancreas Technology in 2026
What a Closed Loop System for Insulin Delivery Contains: Breaking Down Artificial Pancreas Technology in 2026 Review Key Takeaways Closed-loop insulin delivery systems represent a revolutionary advancement in diabetes management, combining three essential components to automate blood sugar control and significantly improve patient outcomes.
