Evidence-based clinical review Polypharmacy at the End of Life: Why Are So Many Patients Still Taking Statins and Bisphosphonates? A prognosis- and goals-based approach to preventive medications, with important exceptions for recent ASCVD, high fracture risk, and active cancer indications Estimated
Aging in Place
Falls as a Cardiovascular Symptom: Hidden Orthostatic Hypotension, Atrial Fibrillation Therapies, and When Pacemakers Help
Frailty Before the ICU: Using Frailty Scores to Guide Escalation Without Turning Them Into Gatekeepers
Frailty Before the ICU: Using Frailty Scores to Guide Escalation Without Turning Them Into Gatekeepers Review Abstract Purpose: Frailty has emerged as an important predictor of adverse outcomes in hospitalized and critically ill adults, particularly among older patients with multiple chronic conditions. As healthcare systems increasingly care
Senescent Cells: Therapeutic Target, Biological Signal, or Red Herring?
Senescent Cells: Therapeutic Target, Biological Signal, or Red Herring? Longevity Series Brief Summary This article explores one of the most intriguing questions in modern geroscience: whether senescent cells are actionable therapeutic targets or merely biological bystanders associated with aging and chronic disease. The answer
Healthspan vs. Lifespan: Are We Measuring the Years That Matter?
Healthspan vs. Lifespan: Are We Measuring the Years That Matter? Longevity Series Brief Summary This article explores the growing distinction between lifespan and healthspan. Lifespan asks how long people live. Healthspan asks how much of that life is lived with preserved function, independence, cognition, mobility,
Frailty-Adjusted Anesthesia: Should Physiologic Age Replace Chronologic Age?
Frailty-Adjusted Anesthesia: Should Physiologic Age Replace Chronologic Age? Review Abstract Chronologic age has traditionally served as a cornerstone of perioperative risk assessment and clinical decision making. While advancing age is associated with an increased likelihood of postoperative complications, it is increasingly recognized that age alone provides an
Perimenopause vs Thyroid vs Mood: Sorting Symptom Overlap Efficiently
Perimenopause vs Thyroid vs Mood Sorting Symptom Overlap Efficiently Review Abstract Perimenopause, thyroid dysfunction, depression, and anxiety represent some of the most common and diagnostically challenging conditions encountered in midlife clinical practice. These disorders frequently coexist and share a broad range of overlapping symptoms, creating major complexity
Osteoporosis Treatment Sequencing: Where Do the Anabolics Fit In?
Osteoporosis Treatment Sequencing Where Do the Anabolics Fit In Review Abstract Osteoporosis management has undergone a remarkable transformation in recent years, moving away from a uniform antiresorptive-first treatment paradigm toward a more individualized, risk-based approach that prioritizes fracture prevention according to the patient’s absolute risk profile. This evolution
Cosmeceuticals vs Prescription Therapy: Where Does Science End and Marketing Begin?
Cosmeceuticals vs Prescription Therapy: Where Does Science End and Marketing Begin? Review Abstract The distinction between cosmeceuticals and prescription dermatologic therapies has become progressively less defined, creating a complex therapeutic landscape for clinicians and patients. Cosmeceuticals are commonly described as topical products that occupy an
Genitourinary Syndrome of Menopause: Why Are So Many Patients Still Suffering?
Genitourinary Syndrome of Menopause Why Are So Many Patients Still Suffering Review Abstract Genitourinary syndrome of menopause (GSM) is a highly prevalent yet frequently underrecognized condition that affects up to 84 percent of postmenopausal women. Previously referred to as vulvovaginal atrophy, GSM encompasses a spectrum
