ATR and WEE1 Inhibitors After PARP Resistance: Emerging DNA Damage Response Strategies Across Solid Tumors Review Abstract Background Resistance to poly(ADP-ribose) polymerase (PARP) inhibition has intensified interest in other components of the DNA damage response and replication-stress network. Early clinical studies have evaluated ataxia telangiectasia
Hematology
BTK Degraders in CLL/SLL After BTK Inhibitor Failure: A Promising Escape Route Still Under Study
BTK Degraders in CLL/SLL After BTK Inhibitor Failure: A Promising Escape Route Still Under Study Review Abstract Purpose: This review assesses the rationale, emerging clinical evidence, safety considerations, and practical implications of Bruton tyrosine kinase (BTK) degraders in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), particularly after
Can Bispecific Antibodies Move Safely Into the Outpatient Clinic? A Label-Concordant Framework for Clinicians
Can Bispecific Antibodies Move Safely Into the Outpatient Clinic? A Label-Concordant Framework for Clinicians Review Abstract Purpose: This review assesses whether CD3-engaging bispecific antibody therapy can be delivered safely in outpatient oncology settings, with emphasis on cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, infection prevention,
Environmental and Lifestyle Hematology: How Air Pollution and Chronic Stress Influence Hematopoiesis, Inflammation, and Vascular Risk
Environmental and Lifestyle Hematology: The Influence of Air Pollution and Chronic Stress on Hematopoiesis, Inflammation, and Vascular Risk Review Abstract Purpose: This review examines how fine particulate air pollution and chronic psychosocial stress may influence hematopoiesis, inflammatory leukocyte production, coagulation biology, clonal hematopoiesis, and cardiovascular risk.
Thrombosis and Cancer Immunotherapy: The Next Frontier of Thromboinflammation
Thrombosis and Cancer Immunotherapy The Next Frontier of Thromboinflammation Review Abstract Cancer immunotherapy has fundamentally transformed the treatment landscape across multiple malignancies, offering durable responses and prolonged survival in patients with previously limited therapeutic options. Immune checkpoint inhibitors, chimeric antigen receptor T cell therapies, bispecific antibodies,
Iron Deficiency Without Anemia: Fatigue Workup That Leads to Actionable Fixes
Iron Deficiency Without Anemia Fatigue Workup That Leads to Actionable Fixes Review Abstract Iron deficiency without anemia (IDWA) is a prevalent yet frequently underrecognized condition in clinical practice that can greatly impair patient well being and functional capacity. It is particularly common among women of reproductive
CAR T Cell Therapy: The Truth About Off-the-Shelf Treatments in 2026
CAR T Cell Therapy The Truth About Off-the-Shelf Treatments in 2026 Review Key Takeaways Chimeric antigen receptor T cell therapy has transformed the treatment landscape for several hematologic malignancies, offering the potential for durable remission in patients with otherwise refractory disease. Conventional CAR T cell therapy relies on
Fibromyalgia and Lupus Together: Why Composite Disease Scores May Mislead Clinicians
Fibromyalgia and Lupus Together Why Composite Disease Scores May Mislead Clinicians Key Takeaways Accurate differentiation between fibromyalgia and systemic lupus erythematosus remains one of the most important challenges in rheumatologic practice, particularly because both conditions frequently coexist and share several subjective symptoms that can complicate clinical interpretation. In patients with
Understanding VITT: What Vaccine Safety Experts Learned Beyond COVID-19
Understanding VITT: What Vaccine Safety Experts Learned Beyond COVID-19 Key Takeaways Vaccine induced thrombotic thrombocytopenia, commonly referred to as VITT, has become one of the most important examples of how rapid scientific collaboration can reshape clinical outcomes during a global public health emergency. First recognized
AI in Hematopathology: How Digital Smears Enable Automated Blood Cell Classification
AI in Hematopathology: How Digital Smears Enable Automated Blood Cell Classification Key Takeaways AI-powered digital microscopy is revolutionizing blood cell analysis, achieving diagnostic accuracy rates up to 95% while dramatically reducing processing time and improving statistical reliability through massive cell analysis capabilities. AI achieves
