Thrombosis and Cancer Immunotherapy The Next Frontier of Thromboinflammation Review Abstract Cancer immunotherapy has fundamentally transformed the treatment landscape across multiple malignancies, offering durable responses and prolonged survival in patients with previously limited therapeutic options. Immune checkpoint inhibitors, chimeric antigen receptor T cell therapies, bispecific antibodies,
Hematology
Iron Deficiency Without Anemia: Fatigue Workup That Leads to Actionable Fixes
Iron Deficiency Without Anemia Fatigue Workup That Leads to Actionable Fixes Review Abstract Iron deficiency without anemia (IDWA) is a prevalent yet frequently underrecognized condition in clinical practice that can greatly impair patient well being and functional capacity. It is particularly common among women of reproductive
CAR T Cell Therapy: The Truth About Off-the-Shelf Treatments in 2026
CAR T Cell Therapy The Truth About Off-the-Shelf Treatments in 2026 Review Key Takeaways Chimeric antigen receptor T cell therapy has transformed the treatment landscape for several hematologic malignancies, offering the potential for durable remission in patients with otherwise refractory disease. Conventional CAR T cell therapy relies on
Fibromyalgia and Lupus Together: Why Composite Disease Scores May Mislead Clinicians
Fibromyalgia and Lupus Together Why Composite Disease Scores May Mislead Clinicians Key Takeaways Accurate differentiation between fibromyalgia and systemic lupus erythematosus remains one of the most important challenges in rheumatologic practice, particularly because both conditions frequently coexist and share several subjective symptoms that can complicate clinical interpretation. In patients with
Understanding VITT: What Vaccine Safety Experts Learned Beyond COVID-19
Understanding VITT: What Vaccine Safety Experts Learned Beyond COVID-19 Key Takeaways Vaccine induced thrombotic thrombocytopenia, commonly referred to as VITT, has become one of the most important examples of how rapid scientific collaboration can reshape clinical outcomes during a global public health emergency. First recognized
AI in Hematopathology: How Digital Smears Enable Automated Blood Cell Classification
AI in Hematopathology: How Digital Smears Enable Automated Blood Cell Classification Key Takeaways AI-powered digital microscopy is revolutionizing blood cell analysis, achieving diagnostic accuracy rates up to 95% while dramatically reducing processing time and improving statistical reliability through massive cell analysis capabilities. AI achieves
Artificial Blood and Oxygen Carriers: The Next Revolution in Intraoperative Safety
Artificial Blood and Oxygen Carriers The Next Revolution in Intraoperative Safety Abstract The development of artificial blood and oxygen carrying substitutes represents a significant milestone in perioperative medicine, offering potential solutions to persistent challenges surrounding blood transfusion safety, supply constraints, and compatibility. Although allogeneic blood transfusion remains a
Platelet Function Testing vs Standard Care: What Clinical Data Really Shows
Platelet Function Testing vs Standard Care What Clinical Data Really Shows Introduction High on treatment platelet reactivity remains a significant clinical challenge in patients receiving clopidogrel, with approximately one in three treated individuals demonstrating inadequate platelet inhibition. This variability in response has important therapeutic
Targeting the Bone Marrow Microenvironment in Myeloma and Acute Myeloid Leukemia: Novel Therapeutic Approaches and Clinical Implications
Targeting the Bone Marrow Microenvironment in Myeloma and Acute Myeloid Leukemia Novel Therapeutic Approaches and Clinical Implications Abstract The bone marrow microenvironment is increasingly recognized as a central determinant in the initiation, progression, and therapeutic resistance of hematologic malignancies, particularly multiple myeloma and acute myeloid leukemia
Anemia of Chronic Disease: Unravelling New Pathways Beyond Iron
Anemia of Chronic Disease: Unravelling New Pathways Beyond Iron Abstract Anemia of chronic disease (ACD) represents the second most common form of anemia worldwide, affecting millions of patients with underlying inflammatory conditions. Traditionally understood as a disorder primarily involving disruption of iron metabolism, recent
