ATR and WEE1 Inhibitors After PARP Resistance: Emerging DNA Damage Response Strategies Across Solid Tumors

ATR and WEE1 Inhibitors After PARP Resistance: Emerging DNA Damage Response Strategies Across Solid Tumors Review Abstract Background Resistance to poly(ADP-ribose) polymerase (PARP) inhibition has intensified interest in other components of the DNA damage response and replication-stress network. Early clinical studies have evaluated ataxia telangiectasia

Constructive Uses For Biomarker Testing In Dementia

Constructive Uses For Biomarker Testing In Dementia Overview The Investigating the Impact of Alzheimer’s Disease Diagnostics in British Columbia (IMPACT-AD BC) study aimed to evaluate the effects of Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarker testing on medical decision-making, personal decision-making, and health system economics. This observational, longitudinal cohort study enrolled 149

ATR and WEE1 Inhibitors After PARP Resistance: Emerging DNA Damage Response Strategies Across Solid Tumors