ATR and WEE1 Inhibitors After PARP Resistance: Emerging DNA Damage Response Strategies Across Solid Tumors Review Abstract Background Resistance to poly(ADP-ribose) polymerase (PARP) inhibition has intensified interest in other components of the DNA damage response and replication-stress network. Early clinical studies have evaluated ataxia telangiectasia
Tag: DNA damage response
The Cancer Risk Paradox of Anti-Aging Therapies
The Cancer Risk Paradox of Anti-Aging Therapies Abstract The relationship between anti-aging interventions and cancer risk presents a complex biological paradox that demands careful examination by healthcare practitioners. While many anti-aging therapies aim to promote cellular health and longevity, they may inadvertently create conditions that
The New Frontier in Longevity Science: Senolytics and Age-Reversal Therapies
The New Frontier in Longevity Science: Senolytics and Age-Reversal Therapies Introduction Approximately 80% of adults over age 65 worldwide develop at least one chronic condition, from arthritis to dementia. Recent longevity research has identified cellular senescence as a fundamental driver of age-related decline. These
