Evidence-based clinical review Intratumoral Immunotherapy and In-Situ Vaccination: Local Shots, Systemic Responses? What clinicians should know about tumor-directed immune therapy, distant lesion responses, and the limits of current evidence Estimated reading time: 20 minutes Abstract
Tag: cancer immunotherapy
Can Bispecific Antibodies Move Safely Into the Outpatient Clinic? A Label-Concordant Framework for Clinicians
Can Bispecific Antibodies Move Safely Into the Outpatient Clinic? A Label-Concordant Framework for Clinicians Review Abstract Purpose: This review assesses whether CD3-engaging bispecific antibody therapy can be delivered safely in outpatient oncology settings, with emphasis on cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, infection prevention,
Cytokine Release Syndrome 2.0: Managing Immune-Effector Toxicity as Cell Therapy Moves Earlier, Broader, and Beyond CAR T
Cytokine Release Syndrome 2.0: Managing Immune-Effector Toxicity as Cell Therapy Moves Earlier, Broader, and Beyond CAR T Review Abstract Purpose: This article reviews cytokine release syndrome (CRS) and related immune-effector toxicities in the expanding era of cellular therapy, with emphasis on practical recognition, risk stratification,
Thrombosis and Cancer Immunotherapy: The Next Frontier of Thromboinflammation
Thrombosis and Cancer Immunotherapy The Next Frontier of Thromboinflammation Review Abstract Cancer immunotherapy has fundamentally transformed the treatment landscape across multiple malignancies, offering durable responses and prolonged survival in patients with previously limited therapeutic options. Immune checkpoint inhibitors, chimeric antigen receptor T cell therapies, bispecific antibodies,
CAR T Cell Therapy: The Truth About Off-the-Shelf Treatments in 2026
CAR T Cell Therapy The Truth About Off-the-Shelf Treatments in 2026 Review Key Takeaways Chimeric antigen receptor T cell therapy has transformed the treatment landscape for several hematologic malignancies, offering the potential for durable remission in patients with otherwise refractory disease. Conventional CAR T cell therapy relies on
The Microbiome as a Cancer Therapy Lever: Real Clinical Tool or Science Fair?
The Microbiome as a Cancer Therapy Lever: Real Clinical Tool or Science Fair? Abstract The human microbiome has emerged as a potential therapeutic target in oncology, generating considerable interest among researchers and clinicians. This analysis examines current evidence on microbiome-based cancer interventions, evaluating their clinical
Cytokine Engineering: IL-2, IL-15, and Beyond
Cytokine Engineering: IL-2, IL-15, and Beyond Check out our extensive video library (see channel for our latest videos) Abstract This paper looks into cytokine engineering, with particular focus on interleukin-2 (IL-2) and interleukin-15 (IL-15). These proteins play essential roles in immune system regulation and
Fecal Microbiota Transplantation: From Gut Health to Cancer Treatment Success
Fecal Microbiota Transplantation: From Gut Health to Cancer Treatment Success Introduction Fecal microbiota transplantation (FMT) has emerged as a novel and highly promising strategy in the field of cancer immunotherapy. Recent clinical studies have reported objective response rates of up to 65 percent among
TIL Therapy Breakthrough: New Hope for Solid Tumor Treatment in 2025
TIL Therapy Breakthrough: New Hope for Solid Tumor Treatment in 2025 Introduction Tumor-Infiltrating Lymphocytes (TILs) represent a groundbreaking advancement in solid cancer treatment, offering new hope to patients with remarkable response rates and extended survival outcomes. This innovative immunotherapy approach extracts immune cells
Targeted Therapy vs. Immunotherapy in Oncology: Advancements and Comparisons Since 2022
Targeted Therapy vs. Immunotherapy in Oncology: Advancements and Comparisons Since 2022 Abstract This paper analyzes the recent developments in targeted therapy and immunotherapy for cancer treatment, focusing on advancements made since 2022. It compares these two approaches by examining their mechanisms, effectiveness, and potential applications across
