BTK Degraders in CLL/SLL After BTK Inhibitor Failure: A Promising Escape Route Still Under Study Review Abstract Purpose: This review assesses the rationale, emerging clinical evidence, safety considerations, and practical implications of Bruton tyrosine kinase (BTK) degraders in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), particularly after
Tag: hematology
Can Bispecific Antibodies Move Safely Into the Outpatient Clinic? A Label-Concordant Framework for Clinicians
Can Bispecific Antibodies Move Safely Into the Outpatient Clinic? A Label-Concordant Framework for Clinicians Review Abstract Purpose: This review assesses whether CD3-engaging bispecific antibody therapy can be delivered safely in outpatient oncology settings, with emphasis on cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, infection prevention,
Environmental and Lifestyle Hematology: How Air Pollution and Chronic Stress Influence Hematopoiesis, Inflammation, and Vascular Risk
Environmental and Lifestyle Hematology: The Influence of Air Pollution and Chronic Stress on Hematopoiesis, Inflammation, and Vascular Risk Review Abstract Purpose: This review examines how fine particulate air pollution and chronic psychosocial stress may influence hematopoiesis, inflammatory leukocyte production, coagulation biology, clonal hematopoiesis, and cardiovascular risk.
VEXAS Syndrome: The Newly Discovered Disorder Every Hematologist Should Know
VEXAS Syndrome: The Newly Discovered Disorder Every Hematologist Should Know Check back later for a possible video summary. Videos are created for most articles. Abstract This paper provides a comprehensive review of VEXAS syndrome; a newly recognized, adult-onset autoinflammatory condition with a genetic basis and complex multisystem involvement, carrying significant implications for hematologists, rheumatologists, and other specialists. First
Plasmapheresis in TTP Mimics: When Are We Getting It Wrong?
Plasmapheresis in TTP Mimics: When Are We Getting It Wrong? Check back later for a possible video summary. Videos are created for most articles. Introduction Plasmapheresis has revolutionized the treatment of thrombotic thrombocytopenic purpura (TTP), reducing mortality rates from nearly 100% to less than 10–20%. Despite this progress, diagnostic uncertainty remains a
Monoclonal Antibodies in Relapsed Multiple Myeloma: The Era of Bispecifics and Beyond
Monoclonal Antibodies in Relapsed Multiple Myeloma: The Era of Bispecifics and Beyond Check back later for a possible video summary. Videos are created for most articles. Abstract This paper provides an in-depth review of monoclonal antibody (mAb) therapies in the treatment of relapsed multiple myeloma (MM), with a particular focus on bispecific antibodies
Thrombocytopenia in the ICU: Essential Guide for Clinical Hematologists
Thrombocytopenia in the ICU: Essential Guide for Clinical Hematologists Please like and subscribe if you enjoyed this video :-) Introduction Thrombocytopenia is a frequent hematologic abnormality in critically ill patients, affecting up to 67.6% at ICU admission, with an additional 14–44% developing it during their stay.
Breaking Barriers: CAR-T Therapy Shows Promise Against Solid Tumors
IRON DEFICIENCY’S IMPACT ON NEW-ONSET CHRONIC HEART FAILURE OUTCOME: DANISH HEART FAILURE REGISTRY INSIGHTS
Rusfertide Treatment For Elevated Red Blood Cell Production
Rusfertide Treatment For Elevated Red Blood Cell Production Overview Polycythemia vera is a chronic myeloproliferative disorder marked by elevated red blood cell production. Rusfertide, a peptide mimetic of the iron-regulating hormone hepcidin, has been developed to limit iron availability for erythropoiesis. However, its safety and efficacy in patients with polycythemia vera who
