Adult Sepsis Management in Internal Medicine: Are We Overtreating, Undertreating, or Targeting the Wrong Metrics? Review Abstract Background Management of adult sepsis requires prompt decision-making amid uncertainty about infection, organ dysfunction, hemodynamic status, and treatment responsiveness. Although standardized care pathways may reduce harmful delays, indiscriminate
Infectious Disease
Vaccines and Catch-Up in 2026: Schedule Navigation, Documentation, and Vaccine Confidence for Clinicians
Vaccines and Catch-Up in 2026: Schedule Navigation, Documentation, and Vaccine Confidence for Clinicians Review Abstract Purpose: This review provides a comprehensive overview of contemporary vaccine practice in 2026, with emphasis on immunization schedule navigation, catch up vaccination, documentation standards, vaccine safety, product specific recommendations, and evidence based communication
GlobalRPh Vancomycin Dosing and Bayesian AUC Advanced Calculator
Introducing the GlobalRPh Vancomycin Dosing and Bayesian AUC Calculator Advanced (Beta) Five population models, conventional pharmacokinetics, Bayesian forecasting, and clinician-directed AUC dosing in one platform A formal introduction to the Advanced calculator's conventional AUC workflow, Bayesian mathematics, five population-specific models, model-selection safeguards, and clinician-directed
HIV in the Era of Long-Acting Injectables: Redefining Adherence Without Abandoning Follow-Up
HIV in the Era of Long-Acting Injectables: Redefining Adherence Without Abandoning Follow-Up Reviewed and updated July 29, 2026 Abstract Purpose: This review examines how long-acting injectable antiretroviral therapy and injectable HIV pre-exposure prophylaxis are changing treatment, prevention, and adherence frameworks in HIV care. Methodology: The
Fungal Infections in the ICU: Missed Disease, Colonization, and the Cost of Overcalling Candida
Fungal Infections in the ICU: Missed Disease, Colonization, and the Cost of Overcalling Candida Review Abstract Purpose: This review examines the diagnostic and therapeutic challenges of fungal infections in the intensive care unit, with emphasis on distinguishing missed invasive disease from colonization, biomarker noise, and
RSV Monoclonal Antibodies: A Paradigm Shift in Infant Protection
RSV Monoclonal Antibodies: A Paradigm Shift in Infant Protection Review Abstract Purpose: This review examines the evolving role of long-acting respiratory syncytial virus monoclonal antibodies in preventing RSV lower respiratory tract disease in infants and selected young children. Methodology: This article reviews current CDC and
The Changing Geography of Sexually Transmitted Infections in the United States
The Changing Geography of Sexually Transmitted Infections in the United States: State-Level Burden, Emerging Threats, and the Limits of Single-Exposure Risk Prediction Emerging Risks Abstract Purpose: This paper reviews recent U.S. trends in sexually transmitted infections (STIs), commonly called sexually transmitted diseases (STDs) when clinical disease
The Rise of Pan-Resistant Gram-Negatives: Are We Running Out of Options?
The Rise of Pan-Resistant Gram-Negatives: Are We Running Out of Options? Review Abstract Pan-resistant gram-negative bacteria represent one of the most pressing challenges in modern medicine. These organisms exhibit resistance to virtually all available antimicrobial agents, leaving clinicians with extremely limited therapeutic options. This paper
The Return of Old Antibiotics: Are Colistin and Fosfomycin Making a Comeback?
The Return of Old Antibiotics: Are Colistin and Fosfomycin Making a Comeback? Review Abstract The rise of multidrug-resistant bacterial infections has forced clinicians to reconsider older antimicrobial agents previously abandoned due to toxicity concerns. Colistin and fosfomycin, antibiotics discovered decades ago, have experienced renewed clinical
Post-COVID Pulmonary Changes: Are “Routine” Cases Now Higher Risk?
Post-COVID Pulmonary Changes Are “Routine” Cases Now Higher Risk Abstract The COVID 19 pandemic has produced lasting consequences that extend far beyond the acute infectious phase, fundamentally reshaping respiratory medicine, perioperative evaluation, and risk assessment across multiple clinical disciplines. Although the acute burden of severe SARS
