Methotrexate Accumulation In Patient Guts: Target Intestinal Mucosa Variation By Disease State Overview This study investigates the accumulation of intracellular methotrexate polyglutamates (MTX-PGs) in different cell types to identify a more accurate biomarker for methotrexate (MTX) therapy in Crohn’s disease (CD) patients. MTX-PG3 concentrations in red blood cells (RBCs) are known to
Gastroenterology
Colitis Risk Increase In Inflammatory Eye Disease Patients
Colitis Risk Increase In Inflammatory Eye Disease Patients Overview Microscopic colitis (MC) is an inflammatory condition affecting the colon, but its association with inflammatory eye diseases remains unclear. This study aimed to determine if inflammatory eye diseases, specifically iridocyclitis and episcleritis, are risk factors for developing MC. Using the ESPRESSO database, which includes
Sjögren’s Disease Leads To Mental Health Meltdown
Sjögren’s Disease Leads To Mental Health Meltdown Overview Primary Sjögren’s syndrome (pSS) is a well-known autoimmune disorder characterized by inflammation of the glands, leading to symptoms such as dry eyes and mouth. While traditionally associated with peripheral glandular issues, Sjögren’s syndrome also impacts the central nervous system (CNS), manifesting in various neuropsychiatric
Mobile App Users Do Better Losing Weight
Mobile App Users Do Better Losing Weight Overview With the rise in global obesity rates and related health problems, there is a growing need for accessible weight management solutions. Mobile applications provide such accessibility and can serve as effective alternatives to traditional healthcare models for weight management. This study aims to evaluate the
Obesity Diminished: Patients Stay Aligned With Weight Loss Programs
Obesity Diminished: Patients Stay Aligned With Weight Loss Programs Overview Adherence is crucial for realizing the full benefits of a weight loss intervention. Although numerous studies have explored factors that promote adherence, their findings are often inconsistent and fragmented. This study aims to review existing adherence factors in weight loss interventions and
Weight Loss: Taking Action To See Results
Weight Loss: Taking Action To See Results Overview Obesity rates in Latin America rank among the highest globally, with people with obesity (PWO) often receiving inadequate care due to various challenges and barriers. The international ACTION-IO study aimed to explore perceptions, attitudes, and behaviors of PWO and healthcare providers (HCPs) and to
Menopause Attitudes, Body Image, And Eating Disorders Affect Quality Of Life
Menopause Attitudes, Body Image, And Eating Disorders Affect Quality Of Life Overview The experiences and quality of life during menopause can greatly differ among women. While menopause is often linked to adverse effects on eating habits and body image, the impact on quality of life based on eating disorder risk status is
Silica Dust: Does It Ignite Inflammation In The Gut And Eye
Silica Dust: Does It Ignite Inflammation In The Gut And Eye Ulcerative colitis (UC) is a chronic inflammatory ailment of the colon. It is considered a part of the inflammatory bowel disease (IBD) category. It causes inflammation and ulcers in the colon's lining, usually starting in the rectum and spreading upward.
Colorectal Cancer Prognosis And Mortality Risk Improved By Eating Healthy Diet
Colorectal Cancer Prognosis And Mortality Risk Improved By Eating Healthy Diet Overview The relationship between diet and colorectal cancer prognosis remains poorly understood, and there are no specific lifestyle recommendations available. A comprehensive search for randomized controlled trials (RCTs) and longitudinal observational studies examining post-diagnosis dietary factors, supplement use, and colorectal cancer
Beware – Gastric Cancer Protection Collapsed By Alcohol Intake
Beware - Gastric Cancer Protection Collapsed By Alcohol Intake Overview Dietary folate intake has been suggested as a potentially modifiable factor influencing gastric cancer (GC) risk, though existing evidence remains inconclusive. This study assesses the relationship between dietary folate intake and GC risk, along with the modifying effect of alcohol consumption. Data
