Posterior Cortical Atrophy, Primary Progressive Aphasia, and the Non-Amnestic Alzheimer's Patient Review Abstract Alzheimer's disease is often marked by progressive episodic memory loss, but not all patients start with an amnestic syndrome. Some patients may initially present with issues in visual-spatial skills, language, executive function,
Internal Medicine
The Changing Geography of Sexually Transmitted Infections in the United States
The Changing Geography of Sexually Transmitted Infections in the United States: State-Level Burden, Emerging Threats, and the Limits of Single-Exposure Risk Prediction Emerging Risks Abstract Purpose: This paper reviews recent U.S. trends in sexually transmitted infections (STIs), commonly called sexually transmitted diseases (STDs) when clinical disease
The New Hospitalist Dilemma: When Every Elderly Admission Is a Delirium Prevention Case
The New Hospitalist Dilemma: When Every Elderly Admission Is a Delirium Prevention Case Review Abstract Delirium is one of the most common and consequential complications of hospitalization in older adults. It is associated with longer length of stay, functional decline, institutionalization, mortality, higher costs, and
Trauma in Older Adults on Anticoagulation: When Reversal Helps—and When Observation Is Safer
Trauma in Older Adults on Anticoagulation: When Reversal Helps and When Observation Is Safer Review Abstract The management of older trauma patients receiving anticoagulant therapy requires rapid but individualized decision-making. As anticoagulant use has increased for atrial fibrillation, venous thromboembolism, mechanical heart valves, and other
Primary Aldosteronism: One of the Most Missed Diagnoses in Internal Medicine?
Primary Aldosteronism: One of the Most Missed Diagnoses in Internal Medicine? Review Abstract Primary aldosteronism is one of the most common, treatable, and underdiagnosed causes of hypertension. Once viewed as a rare disorder defined by severe hypertension and hypokalemia, it is now recognized as a
Coronary Artery Calcium Scoring in 2026: Still Powerful, but Only When Used for the Right Patient
Coronary Artery Calcium Scoring in 2026: Still Powerful, but Only When Used for the Right Patient Review Key Takeaways Coronary artery calcium (CAC) scoring continues to occupy an important role in contemporary cardiovascular risk assessment and remains far from obsolete. Although advances in cardiovascular imaging, biomarker testing, and
Nail Disorders as Clues to Systemic Disease: Evidence, Limitations, and Diagnostic Value in Clinical Practice
Nail Disorders as Clues to Systemic Disease: Evidence, Limitations, and Diagnostic Value in Clinical Practice Review Abstract The physical examination remains a cornerstone of clinical medicine, yet certain components are frequently overlooked despite their diagnostic value. Among these, examination of the nail unit represents a
The Glucagon Paradox in Next-Generation Incretin Therapy: GLP-1, GIP, and Glucagon Receptor Co-Agonism
The Glucagon Paradox in Next-Generation Incretin Therapy: How GLP-1, GIP, and Glucagon Receptor Co-Agonism May Amplify Weight Loss Despite Glucagon’s Hyperglycemic Biology D. Mcauley Abstract The development of dual and triple incretin-based receptor agonists represents a major advance in the pharmacologic treatment of obesity, type
Obesity, Metabolic Syndrome, and ‘Difficult-to-Treat’ Psoriatic Arthritis: Is Inflammation Only Half the Story?
Obesity, Metabolic Syndrome, and ‘Difficult-to-Treat’ Psoriatic Arthritis Is Inflammation Only Half the Story Review Abstract Psoriatic arthritis (PsA) is a chronic, immune mediated inflammatory musculoskeletal disease that affects a substantial proportion of individuals with psoriasis. Characterized by peripheral arthritis, enthesitis, dactylitis, axial involvement, and progressive joint damage, PsA is associated
The Rise of Pan-Resistant Gram-Negatives: Are We Running Out of Options?
The Rise of Pan-Resistant Gram-Negatives: Are We Running Out of Options? Review Abstract Pan-resistant gram-negative bacteria represent one of the most pressing challenges in modern medicine. These organisms exhibit resistance to virtually all available antimicrobial agents, leaving clinicians with extremely limited therapeutic options. This paper
