ATR and WEE1 Inhibitors After PARP Resistance: Emerging DNA Damage Response Strategies Across Solid Tumors

ATR and WEE1 Inhibitors After PARP Resistance: Emerging DNA Damage Response Strategies Across Solid Tumors Review Abstract Background Resistance to poly(ADP-ribose) polymerase (PARP) inhibition has intensified interest in other components of the DNA damage response and replication-stress network. Early clinical studies have evaluated ataxia telangiectasia

Thrombolysis in Intermediate-Risk Pulmonary Embolism: Who Should Receive Early Reperfusion?

Thrombolysis in Intermediate-Risk Pulmonary Embolism Who Should Receive Early Reperfusion Review Abstract Background Intermediate-risk pulmonary embolism sits in a genuinely difficult therapeutic space. On one side, you have uncomplicated pulmonary embolism managed primarily with anticoagulation. On the other side, pulmonary embolism complicated by cardiopulmonary failure that demands urgent

Subclinical Thyroid Dysfunction in Family Practice: Evidence, Treatment Thresholds, and Counseling for Patient-Requested Testing

Subclinical Thyroid Dysfunction in Family Practice: Evidence, Treatment Thresholds, and Counseling for Patient-Requested Testing Review Abstract Background Subclinical thyroid dysfunction is defined by biochemistry rather than symptoms. Subclinical hypothyroidism presents as an elevated thyroid-stimulating hormone (TSH) level with a free thyroxine (FT4) level that remains within the

Same-Day Total Hip and Knee Arthroplasty: The Anesthesiologist’s Expanding Role in Ambulatory ERAS

Same-Day Total Hip and Knee Arthroplasty: The Anesthesiologist's Expanding Role in Ambulatory ERAS Review Abstract Background Same-day discharge following elective primary total hip arthroplasty (THA) and total knee arthroplasty (TKA) has become a well-established component of modern orthopedic care. Successful implementation relies on appropriate patient selection, rapid-recovery pathways, multidisciplinary

Skin Cancer Detection and Procedural Decisions in Family Practice: When to Biopsy, Use Cryotherapy, or Refer

Skin Cancer Detection and Procedural Decisions in Family Practice: When to Biopsy, Use Cryotherapy, or Refer Review Abstract Background Evaluation of an identified suspicious skin lesion is fundamentally distinct from routine skin cancer screening. The U.S. Preventive Services Task Force (USPSTF) concludes that evidence is insufficient to

Device-Detected Subclinical Atrial Fibrillation in the Wearable Era: When Is Anticoagulation Justified?

Device-Detected Subclinical Atrial Fibrillation in the Wearable Era: When Is Anticoagulation Justified? Review Abstract Background Consumer wearables, ambulatory electrocardiographic monitors, pacemakers, implantable cardioverter-defibrillators, and implantable cardiac monitors are increasingly identifying brief and asymptomatic atrial arrhythmias. However, a photoplethysmography-based irregular-rhythm notification is not equivalent to a diagnosis

CIDP Overdiagnosis and IVIG Stewardship: Are We Treating the Right Patients for the Right Duration?

CIDP Overdiagnosis and IVIG Stewardship: Are We Treating the Right Patients for the Right Duration? Review Abstract Background Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a highly treatable immune-mediated neuropathy. However, establishing the diagnosis requires a careful integration of the clinical phenotype, electrodiagnostic findings, appropriate supportive evidence,

Resistant Starch, Visceral Fat, and the 40 g/day Research Benchmark: A New GlobalRPh Calculator

GlobalRPh Clinical Nutrition Tool Resistant Starch, Visceral Fat, and the 40 g/day Research Benchmark: A New GlobalRPh Calculator An evidence-based review of resistant starch intake, the 40 g/day RS2 exposure used in key human trials, visceral adipose physiology, and a practical calculator for estimating daily intake. Open

Medication Burden and Deprescribing: A Whole-List Review Approach

GlobalRPh clinical medication-review education Beyond the Pill Count: How Whole-List Review Reveals Hidden Medication Burden How whole-list review can uncover cumulative effects, selected high-consequence combinations, reconciliation gaps, and discussion-ready deprescribing questions that single-drug checks may miss. This article explains the Version 1.5 GlobalRPh analyzer, its formulas,

Top 20 Medical News Topics Clinicians Should Know This Week: August 3-9, 2026

Top 20 Medical News Topics Clinicians Should Know This Week: August 3-9, 2026 Medical NEWS - See topic summary at the end Previous: Top Medical News Topics Clinicians Should Know This Week: July 20-26, 2026 July 6-12, 2026 June 29th