The Rise of Precision Lipidology: Beyond LDL-C to ApoB, Lp(a), and Atherogenic Particle Burden Review Abstract Lipidology is undergoing a clinically important transition from traditional cholesterol-centered assessment toward a more precise evaluation of atherogenic lipoprotein burden. Low-density lipoprotein cholesterol (LDL-C) remains a validated therapeutic target
Immune Aging (Immunosenescence) The Next Major Target for Longevity Medicine
Immune Aging (Immunosenescence) The Next Major Target for Longevity Medicine Abstract The human immune system undergoes gradual decline with advancing age, a process termed immunosenescence. This deterioration represents one of the most promising targets for extending healthy lifespan. Research demonstrates that immune aging contributes to
Foundation Models for Imaging: Are We Entering the Era of ‘Generalist’ Radiology AI?
Foundation Models for Imaging: Are We Entering the Era of ‘Generalist’ Radiology AI? Review Abstract Foundation models represent a transformative development in artificial intelligence that has the potential to fundamentally reshape the field of medical imaging. Unlike traditional machine learning systems that are designed and
MS Phenotypes: Why the Current Classification System May Be Failing Patients
MS Phenotypes: Why the Current Classification System May Be Failing Patients Review Key Takeaways The traditional classification system for multiple sclerosis, established in 1996 by the United States National Multiple Sclerosis Society, continues to shape clinical practice, therapeutic decision making, and clinical trial design nearly three
Pediatric Mental Health Crisis: Navigating the Surge in Anxiety and Depression
Pediatric Mental Health Crisis Navigating the Surge in Anxiety and Depression Review Abstract The current state of pediatric mental health has emerged as one of the most urgent and complex challenges confronting healthcare systems worldwide. Anxiety and depressive disorders among children and adolescents have increased substantially over the past
Post-Polypectomy Surveillance: Are We Over-Scoping Patients (and Under-Scoping the High-Risk Ones)?
Post-Polypectomy Surveillance: Are We Over-Scoping Patients (and Under-Scoping the High-Risk Ones)? Review Key Takeaways Post polypectomy surveillance is a critical component of colorectal cancer prevention strategies, aimed at reducing the incidence of interval colorectal cancers through timely follow up colonoscopy after adenoma removal. However, current surveillance practices
Robotic Surgery Beyond Urology: Which Procedures Are Finally Worth the Docking Time?
Robotic Surgery Beyond Urology: Which Procedures Are Finally Worth the Docking Time? Review Abstract Robotic surgery has undergone substantial expansion since its early adoption in urology, evolving into a widely utilized surgical platform across numerous specialties including general surgery, gynecology, cardiothoracic surgery, colorectal surgery, and orthopedics. Initially
Thrombosis and Cancer Immunotherapy: The Next Frontier of Thromboinflammation
Thrombosis and Cancer Immunotherapy The Next Frontier of Thromboinflammation Review Abstract Cancer immunotherapy has fundamentally transformed the treatment landscape across multiple malignancies, offering durable responses and prolonged survival in patients with previously limited therapeutic options. Immune checkpoint inhibitors, chimeric antigen receptor T cell therapies, bispecific antibodies,
Redefining ADHD in Adults: Overdiagnosis or Underrecognition?
Redefining ADHD in Adults: Overdiagnosis or Underrecognition? Review Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) in adults presents a clinical paradox that challenges current diagnostic practices and understanding. This paper examines the growing debate surrounding adult ADHD diagnosis, exploring whether the increasing rates reflect improved recognition of a previously overlooked condition
The Rise of the “Vertical ED”: Can Standing Reduce Boarding?
The Rise of the “Vertical ED”: Can Standing Reduce Boarding? Review Abstract Emergency department boarding has become a persistent and complex challenge across healthcare systems worldwide. Boarding refers to the prolonged stay of admitted patients in the emergency department after a decision to admit has been
