Lecanemab in Real-World Practice: What Early Alzheimer’s Patients Are Actually Experiencing Review Abstract Lecanemab represents a major milestone in the treatment of Alzheimer’s disease as the first anti amyloid monoclonal antibody to receive traditional approval from the United States Food and Drug Administration for patients with early
Nail Disorders as Clues to Systemic Disease: Evidence, Limitations, and Diagnostic Value in Clinical Practice
Nail Disorders as Clues to Systemic Disease: Evidence, Limitations, and Diagnostic Value in Clinical Practice Review Abstract The physical examination remains a cornerstone of clinical medicine, yet certain components are frequently overlooked despite their diagnostic value. Among these, examination of the nail unit represents a
Osteoporosis Treatment Sequencing: Where Do the Anabolics Fit In?
Osteoporosis Treatment Sequencing Where Do the Anabolics Fit In Review Abstract Osteoporosis management has undergone a remarkable transformation in recent years, moving away from a uniform antiresorptive-first treatment paradigm toward a more individualized, risk-based approach that prioritizes fracture prevention according to the patient’s absolute risk profile. This evolution
The One-Piece Takeaway: How Trail-Hip Lift and Lead-Shoulder Descent Build a Reliable Golf Swing
The One-Piece Takeaway: How Trail-Hip Lift and Lead-Shoulder Descent Build a Reliable Golf Swing D. McAuley - Part of our 'Coffee Break' series Abstract A sound golf swing begins with a connected, one-piece takeaway in which the club, hands, arms, chest, and torso start back
The Glucagon Paradox in Next-Generation Incretin Therapy: GLP-1, GIP, and Glucagon Receptor Co-Agonism
The Glucagon Paradox in Next-Generation Incretin Therapy: How GLP-1, GIP, and Glucagon Receptor Co-Agonism May Amplify Weight Loss Despite Glucagon’s Hyperglycemic Biology D. Mcauley Abstract The development of dual and triple incretin-based receptor agonists represents a major advance in the pharmacologic treatment of obesity, type
Neuromodulation for Depression and Chronic Pain: Beyond Deep Brain Stimulation
Neuromodulation for Depression and Chronic Pain: Beyond Deep Brain Stimulation Review Abstract Neuromodulation therapies have become increasingly important in the management of treatment resistant depression and chronic pain, two conditions that continue to impose substantial personal, societal, and economic burdens worldwide. Despite significant advances in pharmacologic and psychotherapeutic interventions,
Obesity, Metabolic Syndrome, and ‘Difficult-to-Treat’ Psoriatic Arthritis: Is Inflammation Only Half the Story?
Obesity, Metabolic Syndrome, and ‘Difficult-to-Treat’ Psoriatic Arthritis Is Inflammation Only Half the Story Review Abstract Psoriatic arthritis (PsA) is a chronic, immune mediated inflammatory musculoskeletal disease that affects a substantial proportion of individuals with psoriasis. Characterized by peripheral arthritis, enthesitis, dactylitis, axial involvement, and progressive joint damage, PsA is associated
Plasma Biomarkers for Neurodegenerative Disease: What Clinicians Need to Know in 2026
Plasma Biomarkers for Neurodegenerative Disease What Clinicians Need to Know in 2026 Review Key Takeaways Plasma biomarkers are rapidly transforming the diagnosis and management of Alzheimer’s disease and related dementias, representing one of the most notable advances in neurodegenerative medicine in recent decades. Historically, the definitive assessment of Alzheimer’s pathology has
Revolutionizing Diabetes Monitoring: Beyond A1C to Continuous Metabolic Profiling
Revolutionizing Diabetes Monitoring Beyond A1C to Continuous Metabolic Profiling Review Abstract Diabetes mellitus remains one of the most prevalent and challenging chronic diseases worldwide, affecting hundreds of millions of individuals and contributing significantly to cardiovascular disease, kidney failure, blindness, neuropathy, and premature mortality. Effective diabetes management
How to Define Analgesia and Implement Safe Opioid Therapy Protocols in Family Medicine
How to Define Analgesia and Implement Safe Opioid Therapy Protocols in Family Medicine Review Key Takeaways Family physicians occupy a central position in the management of acute and chronic pain, making safe opioid prescribing a critical component of primary care practice. As opioid related morbidity and mortality
