Primary Aldosteronism: One of the Most Missed Diagnoses in Internal Medicine? Review Abstract Primary aldosteronism is one of the most common, treatable, and underdiagnosed causes of hypertension. Once viewed as a rare disorder defined by severe hypertension and hypokalemia, it is now recognized as a
Closed-Incision Negative Pressure Wound Therapy: Which Patients Truly Benefit?
Closed-Incision Negative Pressure Wound Therapy Which Patients Truly Benefit Review Abstract Closed-incision negative pressure wound therapy (ciNPWT), also known as incisional negative pressure wound therapy or prophylactic negative pressure wound therapy, has emerged as an important adjunctive strategy for reducing postoperative wound complications in selected surgical patients.
Coronary Artery Calcium Scoring in 2026: Still Powerful, but Only When Used for the Right Patient
Coronary Artery Calcium Scoring in 2026: Still Powerful, but Only When Used for the Right Patient Review Key Takeaways Coronary artery calcium (CAC) scoring continues to occupy an important role in contemporary cardiovascular risk assessment and remains far from obsolete. Although advances in cardiovascular imaging, biomarker testing, and
GLP-1 Receptor Agonists and Aspiration Risk: From Universal Holding to Risk-Based Perioperative Management
GLP-1 Receptor Agonists and Aspiration Risk: From Universal Holding to Risk-Based Perioperative Management Review Abstract Purpose The rapid adoption of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 (GIP/GLP-1) receptor agonists has transformed the management of type 2 diabetes mellitus and obesity. As the use
Lecanemab in Real-World Practice: What Early Alzheimer’s Patients Are Actually Experiencing
Lecanemab in Real-World Practice: What Early Alzheimer’s Patients Are Actually Experiencing Review Abstract Lecanemab represents a major milestone in the treatment of Alzheimer’s disease as the first anti amyloid monoclonal antibody to receive traditional approval from the United States Food and Drug Administration for patients with early
Nail Disorders as Clues to Systemic Disease: Evidence, Limitations, and Diagnostic Value in Clinical Practice
Nail Disorders as Clues to Systemic Disease: Evidence, Limitations, and Diagnostic Value in Clinical Practice Review Abstract The physical examination remains a cornerstone of clinical medicine, yet certain components are frequently overlooked despite their diagnostic value. Among these, examination of the nail unit represents a
Osteoporosis Treatment Sequencing: Where Do the Anabolics Fit In?
Osteoporosis Treatment Sequencing Where Do the Anabolics Fit In Review Abstract Osteoporosis management has undergone a remarkable transformation in recent years, moving away from a uniform antiresorptive-first treatment paradigm toward a more individualized, risk-based approach that prioritizes fracture prevention according to the patient’s absolute risk profile. This evolution
The One-Piece Takeaway: How Trail-Hip Lift and Lead-Shoulder Descent Build a Reliable Golf Swing
The One-Piece Takeaway: How Trail-Hip Lift and Lead-Shoulder Descent Build a Reliable Golf Swing D. McAuley - Part of our 'Coffee Break' series Abstract A sound golf swing begins with a connected, one-piece takeaway in which the club, hands, arms, chest, and torso start back
The Glucagon Paradox in Next-Generation Incretin Therapy: GLP-1, GIP, and Glucagon Receptor Co-Agonism
The Glucagon Paradox in Next-Generation Incretin Therapy: How GLP-1, GIP, and Glucagon Receptor Co-Agonism May Amplify Weight Loss Despite Glucagon’s Hyperglycemic Biology D. Mcauley Abstract The development of dual and triple incretin-based receptor agonists represents a major advance in the pharmacologic treatment of obesity, type
Neuromodulation for Depression and Chronic Pain: Beyond Deep Brain Stimulation
Neuromodulation for Depression and Chronic Pain: Beyond Deep Brain Stimulation Review Abstract Neuromodulation therapies have become increasingly important in the management of treatment resistant depression and chronic pain, two conditions that continue to impose substantial personal, societal, and economic burdens worldwide. Despite significant advances in pharmacologic and psychotherapeutic interventions,
