The Tirzepatide Revolution: Is Dual Agonism the End of Single-Pathway Therapy? Abstract The development of tirzepatide, a first in class dual glucose dependent insulinotropic polypeptide and glucagon like peptide 1 receptor agonist, represents a potentially transformative advance in the management of type 2 diabetes and obesity. By simultaneously targeting
Why Tau Antibody Trials Failed in Alzheimer’s: New Evidence Reveals Critical Gaps
Why Tau Antibody Trials Failed in Alzheimer’s New Evidence Reveals Critical Gaps Introduction Tau directed antibody therapies represent one of the most scientifically compelling yet clinically challenging areas in the treatment of Alzheimer’s disease. Alzheimer’s disease is a progressive neurodegenerative disorder whose prevalence doubles approximately
Emerging and Approved Therapeutic Peptides: Mechanisms, Clinical Uses
Emerging and Approved Therapeutic Peptides: Mechanisms, Clinical Uses, Safety Profiles, and Regulatory Status Across Health Conditions Abstract Therapeutic peptides represent a rapidly growing class of pharmaceutical agents that bridge the gap between small molecule drugs and large protein therapeutics. This paper examines the
The New Frontier in Longevity Science: Senolytics and Age-Reversal Therapies
The New Frontier in Longevity Science: Senolytics and Age-Reversal Therapies Introduction Approximately 80% of adults over age 65 worldwide develop at least one chronic condition, from arthritis to dementia. Recent longevity research has identified cellular senescence as a fundamental driver of age-related decline. These
BPH Treatment Guidelines 2025: Expert-Validated Algorithm for Patient Care
BPH Treatment Guidelines 2025: Expert-Validated Algorithm for Patient Care Introduction Benign prostatic hyperplasia (BPH) treatment guidelines continue to evolve as the condition affects an overwhelming majority of aging men, with prevalence rates reaching 60% by age 60 and escalating to 80% by age
The Silent Threat: Awareness Under Anesthesia in the Age of Light Sedation
The Silent Threat Awareness Under Anesthesia in the Age of Light Sedation Abstract Purpose This paper examines the phenomenon of awareness under anesthesia, with particular emphasis on its increased risk in the contemporary use of light anesthesia and sedation techniques. As anesthetic practice evolves toward lower drug
Skyrocketing Cancer Drug Prices: Can Oncologists Influence Policy?
Skyrocketing Cancer Drug Prices Can Oncologists Influence Policy Abstract The rapid escalation of cancer drug prices has emerged as a major challenge in contemporary oncology practice, with many newly approved therapies carrying annual costs that exceed one hundred thousand dollars per patient. This
The “Code Sepsis” Fatigue: When Protocols Collide with Clinical Judgment
The “Code Sepsis” Fatigue: When Protocols Collide with Clinical Judgment Abstract The global adoption of standardized sepsis protocols has been a central strategy in improving outcomes for patients with suspected or confirmed sepsis. Initiatives such as early warning systems, sepsis bundles, and time based
The Endocrine Disruptor Epidemic: What Should Clinicians Be Telling Patients?
The Endocrine Disruptor Epidemic: What Should Clinicians Be Telling Patients? Abstract Endocrine disrupting chemicals represent a growing public health concern that requires heightened awareness and engagement from healthcare professionals across disciplines. These substances, which include both synthetic and naturally occurring compounds, have the capacity
Preeclampsia Prediction and Prevention: Are We Entering a New Era?
Preeclampsia Prediction and Prevention Are We Entering a New Era Abstract Preeclampsia remains a major contributor to maternal and perinatal morbidity and mortality worldwide, affecting an estimated 2 to 8 percent of pregnancies. Despite advances in obstetric care, the condition continues to pose significant challenges
