Advanced Gastric Cancer: Prognosis With Nivolumab Monotherapy

Advanced Gastric Cancer: Prognosis With Nivolumab Monotherapy Overview  Later-line treatments for advanced gastric cancer have always been debated. Although chemotherapy is the recommended option. For the last decade, immune checkpoint inhibitors have been used for the treatment of various malignancies. Trials have also been performed for gastric cancer. In this study, a

Sinonasal B‐cell lymphomas: A Cohort Study on Progression and Recurrence

Sinonasal B‐cell lymphomas: A Cohort Study on Progression and Recurrence STUDY BACKGROUND Sinonasal lymphoma is a rare malignancy of rhinologic origin affecting the sinonasal region and surrounding structures. It is a type of non-Hodgkin lymphoma (NHL) comprising around 1.5% of all lymphomas and usually involves males aged between 40 and 70 years.

Platinum-Resistant Recurrent Ovarian Cancer Treatment +/- Bevacizumab

Platinum-Resistant Recurrent Ovarian Cancer Treatment +/- Bevacizumab Overview Of The Study  The study aims to elucidate the efficacy of bevacizumab therapy in patients with platinum-resistant ovarian cancer whose disease has already progressed after bevacizumab plus chemotherapy therapy.  The study is a multicenter, open-label, phase II trial (JGOG3023).  Subjects were randomized 1:1 to single-agent

Metastatic Melanoma and Follow-Up MRI Scans

Metastatic Melanoma and Follow-Up MRI Scans Metastatic melanoma is an aggressive tumor, which may spread to organs either by local invasion, or lymphatic or hematogenous dissemination. Central Nervous System (CNS), especially the brain, account for up to 50% of metastasis. Skin, lymph nodes, lung, and liver are other commonly involved organs,

Isatuximab Treatment in Refractory T-Acute Lymphoblastic Leukemia

Isatuximab Treatment in Refractory T-Acute Lymphoblastic Leukemia The difficulty of making an accurate prognosis of acute T- cell lymphoblastic leukemia (T- ALL) and T- cell lymphoblastic lymphoma (T- LBL) in seniors and patients with relapsed illness has always been an issue in the medical field. Since there is no specified standard

Ocular Melanoma and Treatment with Metformin

Ocular Melanoma and Treatment with Metformin Metformin Activity  Metformin is one of the most common medications for patients with type 2 diabetes mellitus. It is an antihyperglycemic agent that activates the adenosine monophosphate-activated kinase (AMPK). Through this, a person’s cellular ATP levels are restored. The activation of AMPK by metformin suggests that

Lung Cancer with Brain Metastasis After Late-Onset Bipolar Disorder: A Case Report

Lung Cancer with Brain Metastasis After Late-Onset Bipolar Disorder: A Case Report Background Bipolar disorder is a multifactorial illness with uncertain etiology and geriatric new-onset manic episodes are highly associated with secondary organic causes. The presented case demonstrates the importance of excluding secondary causes during the entire disease course.  Overview Bipolar disorder is a

How to Sleep When You Are Not Tired

Patient Education This article is tailored for patients. Refer your patients to this article for them to learn more about their condition. How to Sleep When You Are Not Tired   There are times when you know that you should get some sleep, but you just don’t feel tired enough actually to fall