Endocrine Disruptors and Fertility: What Should Endocrinologists Be Advising?

Endocrine Disruptors and Fertility: What Should Endocrinologists Be Advising?   Abstract Endocrine-disrupting chemicals (EDCs) have emerged as a notable concern in reproductive health, with increasing evidence linking exposure to reduced fertility in both men and women. These compounds, which include a broad spectrum of

Autoimmunity and COVID Vaccines: Risk of Flares or Protective Benefits? A Comprehensive Analysis for Academic and Industry Experts

Autoimmunity and COVID Vaccines: Risk of Flares or Protective Benefits? A Comprehensive Analysis for Academic and Industry Experts  Abstract The link between getting a COVID-19 vaccine and having an autoimmune disease is an intricate blend of immunology, public health, and clinical practice. This analytical review

Giant Cell Arteritis and the Rapid Rise of Tocilizumab: Are Steroids Obsolete?

Giant Cell Arteritis and the Rapid Rise of Tocilizumab: Are Steroids Obsolete? Abstract Giant cell arteritis (GCA) is the most common form of primary systemic vasculitis in adults over 50 years of age and represents a major cause of morbidity, particularly when diagnosis and treatment are delayed. Traditionally, management

New Frontiers in Sickle Cell Disease: CRISPR-Based Cures

New Frontiers in Sickle Cell Disease: CRISPR-Based Cures Abstract Sickle cell disease (SCD) remains one of the most pressing global health challenges, with an estimated 300,000 infants born annually with the disorder and millions more living with its lifelong complications. The burden of SCD is disproportionately higher in

When Blood Tests Lie: The Hidden Truth About Seronegative Rheumatoid Arthritis

When Blood Tests Lie: The Hidden Truth About Seronegative Rheumatoid Arthritis Introduction Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that primarily targets synovial joints, leading to progressive inflammation, cartilage destruction, and bone erosion. Traditionally, diagnosis has relied heavily on the detection of

Venetoclax-based Regimens in AML: The New Standard or a Temporary Fix?

Venetoclax-based Regimens in AML: The New Standard or a Temporary Fix? Abstract Acute myeloid leukemia (AML) remains a challenging hematologic malignancy, particularly among older adults and patients unfit for intensive chemotherapy. Over the past decade, treatment models have shifted with the advent of venetoclax, a selective BCL-2 inhibitor,

Testosterone Replacement Therapy: New Guidelines Challenge Old Beliefs

Testosterone Replacement Therapy: New Guidelines Challenge Old Beliefs Introduction Testosterone replacement therapy (TRT) usage has risen sharply over the past two decades, with rates tripling across the United States. By 2013, an estimated 2.3 million American men were receiving this treatment, reflecting both

The Preventive Medicine Dilemma: How to Keep Patients Healthy in 15 Minutes or Less

The Preventive Medicine Dilemma: How to Keep Patients Healthy in 15 Minutes or Less   Abstract The modern healthcare system faces an urgent challenge: delivering high-quality preventive care within increasingly limited time frames. Evidence shows that the median primary care visit lasts just 15.7