Study on the Ocular involvement in metastatic and systemic malignancies

Ocular Involvement of Systemic Malignancies Systemic malignancies affecting the eye often involve the choroid or the orbital area of the eye, leading to different ocular manifestations. Ocular malignancies are relatively rare compared to malignancies of other parts of the human body. The American Cancer Society estimates there will be about 3,300 new eye cancer

Genetic Mutations for Predicting Pancreatic Ductal Adenocarcinoma Susceptibility

Genetic Mutations for Predicting Pancreatic Ductal Adenocarcinoma Susceptibility Pancreatic ductal adenocarcinoma (PDAC) is the deadliest malignancy representing about 90% of all pancreatic cancers. PDAC progresses asymptomatically until death and is refractory to most treatment methods. Surgery is the most effective treatment. Nevertheless, it is well known that only 15-20% of PDAC

Using Nanofiber Antibiotic Sutures Prevent Ophthalmic Infections

Using Nanofiber Antibiotic Sutures to Prevent Ophthalmic Infections Sutures are medical devices applied on the site of injury or surgery. Sutures prevent infection, minimize scarring, and fasten recovery. As of today, the only drug-eluting sutures available for antibacterial application in most surgeries are coated with >triclosan. It’s known that putting drugs

Exploring Gene Profiles in Small Bowel Adenocarcinoma

Exploring Gene Profiles in Small Bowel Adenocarcinoma Small bowel adenocarcinoma (SBA) is one of the rarest tumors found in patients. In fact, SBA only represents about 1-3% of all gastrointestinal malignancies. Due to its rarity, genomic analyses and prognostic biomarkers are limited. About 55-82% of small bowel adenocarcinomas can be found in

3D MRI FOR NON-INVASIVE OCULAR PROTON THERAPY

3D MRI in Non-Invasive Proton Therapy Treatment Planning of Uveal Melanomas Uveal melanoma (UM) is a rare subset of melanoma, but is the most common primary intraocular tumor in adults. In 85% of cases, melanocytes in the choroid are affected. UM can occasionally arise from the ciliary body or iris. With

Oncology-Specific Opioid Risk Calculator in Cancer Survivors

Oncology-Specific Opioid Risk Calculator in Cancer Survivors Despite the great progress made in terms of diagnosis and treatment, cancer is still a dreaded diagnosis. This devastating disease has a sweeping reach. The International Agency for Research on Cancer (IARC) figures for global cancer burden estimates were 19.3 million new cases and

Meta-Analysis to Determine Optimal Therapy Strategies in Macular Degeneration

Meta-Analysis Results of Clinical Trial Aimed at Determining Optimal Therapeutic Strategies for anti-VEGF Therapy in nAMD Background of this Study Neovascular age-related macular degeneration (nAMD) affects as many as 196 million people worldwide, and is a major cause of severe vision problems including blindness. Despite its prevalence, disagreements about the treatment options

Tool for evaluating real world evidence in treatment of retinal disease

Tool for Evaluating RWE in the Treatment of Retinal Disease   Randomized clinical trials have long been held as the gold standard for evidence based medical practices. However, there is a growing consciousness about the value of incorporating data from real world evidence (RWE) into clinical decision making. Information from real world sources such

The Future of Glaucoma Therapy? Microneedles and the Reduction of Intraocular Pressure

The Future of Glaucoma Therapy? Microneedles and the Reduction of Intraocular Pressure Around 75 million people suffer from glaucoma, making it the world’s leading eye disorder that causes irreversible blindness. Vision loss in glaucoma patients is often accompanied by the dysfunction of the retinal ganglion cell axons. This is believed to