Breaking Through: Latest Advances in Targeting IL-13 and IL-4 for Atopic Diseases Introduction Atopic dermatitis affects up to 25% of children and approximately 10% of adults, including 1-3% of the elderly, making targeting IL-13 and IL-4 in atopic diseases a critical focus for
Hidden Links: How Gut Microbiome Triggers Chronic Inflammation in Disease
Hidden Links: How Gut Microbiome Triggers Chronic Inflammation in Disease Introduction The gut microbiome and inflammation share intricate connections that profoundly impact human health. Often called the “forgotten organ,” the gut microbiota plays critical roles in training and developing major components of the
Cardiac Amyloidosis: The Missing Diagnosis in Preserved Heart Failure Cases
Cardiac Amyloidosis: The Missing Diagnosis in Preserved Heart Failure Cases Introduction Heart failure with preserved ejection fraction (HFpEF) affects about one-third of people with heart failure, making it a difficult condition for doctors to diagnose. Even though HFpEF is common, it often hides
Radiomics in Cancer Care: Breaking Down the Evidence Behind the Buzz
Radiomics in Cancer Care: Breaking Down the Evidence Behind the Buzz Introduction Radiomics represents a rapidly advancing field within oncology that extracts high-dimensional quantitative data from medical imaging, offering the potential to transform cancer diagnosis, prognosis, and treatment strategies. This emerging discipline is built
Solving Long COVID Symptoms: New Research Reveals Hidden Immune Patterns
Solving Long COVID Symptoms: New Research Reveals Hidden Immune Patterns Introduction More than half of individuals with laboratory-confirmed SARS-CoV-2 infection report at least one persistent symptom, underscoring the urgent need for evidence-based approaches to address Long COVID. The condition is highly complex and heterogeneous.
Hidden Systemic Rashes: Critical Signs Every Clinician Must Recognize
Hidden Systemic Rashes: Critical Signs Every Clinician Must Recognize Introduction The skin, as the largest and most visible organ of the human body, plays a vital role in reflecting internal health. Beyond its barrier and immune functions, it often serves as a critical
PE Protocol: Expert Guide to Managing Incidental Findings on CT Scans
PE Protocol: Expert Guide to Managing Incidental Findings on CT Scans Introduction The implementation of proper pulmonary embolism (PE) protocols is a critical component of modern clinical practice. Pulmonary embolism remains a potentially life-threatening condition, occurring in approximately 5% of patients undergoing computed
From Skin to Gut: Unraveling the Immunopathogenesis of Eosinophilic Esophagitis
From Skin to Gut: Unraveling the Immunopathogenesis of Eosinophilic Esophagitis Abstract Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disease of the esophagus [1] that has become a paradigmatic model for understanding the interconnected skin–gut axis in allergic disease. Once considered a rare disorder, EoE has rapidly emerged
The Hidden Link Between Psoriasis and Crohn’s: Essential Insights for Clinical Practice
The Hidden Link Between Psoriasis and Crohn’s: Essential Insights for Clinical Practice Introduction Psoriasis and Crohn’s disease share a complex and clinically notable relationship that extends well beyond coincidental comorbidity. Psoriasis, a chronic immune-mediated skin condition, affects an estimated 2% to 3% of the global population,
Food Allergy Immunotherapy: Why Personalized Treatment Fails for Some Patients
Food Allergy Immunotherapy: Why Personalized Treatment Fails for Some Patients Introduction Food allergies affect 4–8% of children and 3–4% of adults worldwide, with immunotherapy allergy treatments emerging as promising interventions for this growing health burden. Even though allergy immunotherapy was first used in
