Why GLP-1 Non-Responders Need Earlier Anti-Obesity Medication Intervention

Why GLP-1 Non-Responders Need Earlier Anti-Obesity Medication Intervention   Introduction GLP-1 non-responders represent a critical challenge in obesity management that requires prompt medical intervention. Despite the availability of six FDA-approved anti-obesity medications (AOMs) for chronic weight management, current guidelines recommend waiting six months after behavioral therapy

Tachyphylaxis in Antidepressants: The Science Behind Treatment Resistance

Tachyphylaxis in Antidepressants: The Science Behind Treatment Resistance   Introduction Tachyphylaxis is a challenging phenomenon that occurs when antidepressant medications gradually lose their therapeutic efficacy despite continued administration at the same dosage. The prevalence of antidepressant treatment tachyphylaxis is substantial, affecting approximately 25 percent of treated,

The Opioid Crisis in Family Practice: Safe Prescribing vs. Abandoning Patients

The Opioid Crisis in Family Practice: Safe Prescribing vs. Abandoning Patients Abstract The opioid crisis has placed family practice doctors in a challenging position. They must balance providing proper pain care for their patients while avoiding contributing to the widespread addiction and overdose problems facing

Asthma vs. COPD in Primary Care: Are We Missing Asthma-COPD Overlap?

Asthma vs. COPD in Primary Care Are We Missing Asthma-COPD Overlap Abstract Primary care physicians often encounter considerable difficulty when distinguishing between asthma and chronic obstructive pulmonary disease (COPD). Both conditions share overlapping respiratory symptoms such as cough, wheeze, and breathlessness, which can obscure diagnostic clarity and lead to

High-Sensitivity Troponin Testing: The End of Unnecessary Chest Pain Admissions?

High-Sensitivity Troponin Testing: The End of Unnecessary Chest Pain Admissions?   Introduction The introduction of high-sensitivity cardiac troponin (hs-cTn) assays has fundamentally transformed the evaluation and management of patients presenting with chest pain in the emergency department (ED). Troponin testing has long been a cornerstone of acute

Inpatient vs Outpatient Emergency Treatment for Pulmonary Embolism: A Doctor’s Guide

Inpatient vs Outpatient Emergency Treatment for Pulmonary Embolism A Doctor’s Guide   Introduction Pulmonary embolism (PE) remains a major global health concern, affecting an estimated 200,000 to 500,000 individuals each year in the United States. The reported incidence ranges from 39 to 115 cases per 100,000 population,