Prediabetes Management in Family Practice Comparative Effectiveness of Lifestyle Intervention, Metformin, and Anti-Obesity Pharmacotherapy Abstract Prediabetes represents a critical window for intervention in the trajectory toward type 2 diabetes mellitus, offering family physicians an opportunity to prevent or significantly delay disease onset. With global
Postoperative Delirium and Brain Health: Can the Anesthesiologist Prevent Dementia?
Postoperative Delirium and Brain Health Can the Anesthesiologist Prevent Dementia Abstract Postoperative delirium has emerged as a major concern in perioperative medicine, particularly among older adults undergoing surgical procedures. Characterized by an acute and fluctuating disturbance in attention, awareness, and cognition, postoperative delirium affects
CRISPR and Gene Editing in Neurodegenerative Diseases: Current Applications and Future Therapeutic Potential
CRISPR and Gene Editing in Neurodegenerative Diseases Current Applications and Future Therapeutic Potential Abstract Neurodegenerative diseases continue to pose profound challenges to modern medicine, affecting millions of individuals worldwide and contributing significantly to disability, mortality, and healthcare expenditure. Disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease,
Cefepime Neurotoxicity: Underrecognized Risk or Overblown Concern?
Cefepime Neurotoxicity Underrecognized Risk or Overblown Concern Abstract Cefepime is a fourth generation cephalosporin antibiotic that is widely utilized in clinical practice for the treatment of severe and life threatening bacterial infections, including hospital acquired pneumonia, febrile neutropenia, complicated urinary tract infections, and infections caused by
LDL Targets Below 40 mg/dL: How Low Is Too Low in 2026?
LDL Targets Below 40 mg/dL: How Low Is Too Low in 2026? Abstract PurposeThis paper evaluates the current evidence supporting the use of very low low density lipoprotein (LDL) cholesterol targets below 40 mg per deciliter in contemporary cardiovascular practice and examines whether the benefits
mRNA Vaccines in Pregnancy: Reassurance or Lingering Concerns?
mRNA Vaccines in Pregnancy: Reassurance or Lingering Concerns? Abstract This paper reviews the current body of evidence regarding the safety and effectiveness of messenger RNA COVID-19 vaccines during pregnancy and explores the broader implications for emerging mRNA vaccine platforms intended for use in pregnant populations.
The Decline of Physical Examination Skills in Internal Medicine: An Existential Threat?
The Decline of Physical Examination Skills in Internal Medicine An Existential Threat Abstract The physical examination has historically served as a central pillar of medical practice, guiding diagnostic reasoning, informing clinical decision making, and fostering meaningful physician patient relationships. For generations, proficiency in bedside examination has
The Great Vitamin D Debate: Optimal Levels, Supplementation, and Clinical Outcomes
The Great Vitamin D Debate Optimal Levels, Supplementation, and Clinical Outcomes Abstract Vitamin D deficiency is among the most common nutritional disorders globally, affecting an estimated one billion individuals across a wide range of ages, ethnicities, and geographic regions. Contributing factors include limited sunlight
Why Do Teens Vape? New Research Reveals Hidden Brain Changes
Why Do Teens Vape? New Research Reveals Hidden Brain Changes Introduction Despite increasing public awareness of the health risks associated with nicotine use, vaping remains highly prevalent among adolescents. According to 2024 data from the Centers for Disease Control and Prevention, 8.1 percent of
Beyond Psoriasis: Why Biologics Are Reshaping Disease-Specific Dermatology
Beyond Psoriasis: Why Biologics Are Reshaping Disease-Specific Dermatology Introduction Biologics have transformed the therapeutic landscape of chronic inflammatory dermatoses, demonstrating remarkable efficacy and safety profiles in conditions previously challenging to manage. These targeted immunomodulators have revolutionized treatment approaches for moderate-to-severe psoriasis, hidradenitis suppurativa,
