New Frontiers in Sickle Cell Disease: CRISPR-Based Cures Abstract Sickle cell disease (SCD) remains one of the most pressing global health challenges, with an estimated 300,000 infants born annually with the disorder and millions more living with its lifelong complications. The burden of SCD is disproportionately higher in
When Blood Tests Lie: The Hidden Truth About Seronegative Rheumatoid Arthritis
When Blood Tests Lie: The Hidden Truth About Seronegative Rheumatoid Arthritis Introduction Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that primarily targets synovial joints, leading to progressive inflammation, cartilage destruction, and bone erosion. Traditionally, diagnosis has relied heavily on the detection of
Venetoclax-based Regimens in AML: The New Standard or a Temporary Fix?
Venetoclax-based Regimens in AML: The New Standard or a Temporary Fix? Abstract Acute myeloid leukemia (AML) remains a challenging hematologic malignancy, particularly among older adults and patients unfit for intensive chemotherapy. Over the past decade, treatment models have shifted with the advent of venetoclax, a selective BCL-2 inhibitor,
Testosterone Replacement Therapy: New Guidelines Challenge Old Beliefs
Testosterone Replacement Therapy: New Guidelines Challenge Old Beliefs Introduction Testosterone replacement therapy (TRT) usage has risen sharply over the past two decades, with rates tripling across the United States. By 2013, an estimated 2.3 million American men were receiving this treatment, reflecting both
The Preventive Medicine Dilemma: How to Keep Patients Healthy in 15 Minutes or Less
The Preventive Medicine Dilemma: How to Keep Patients Healthy in 15 Minutes or Less Abstract The modern healthcare system faces an urgent challenge: delivering high-quality preventive care within increasingly limited time frames. Evidence shows that the median primary care visit lasts just 15.7
The Truth About Vitamins: What Nutritional Supplement Research Actually Shows in 2025
The Truth About Vitamins: What Nutritional Supplement Research Actually Shows in 2025 Check back later for a possible video summary. Introduction Nutritional supplement use is widespread in the United States, yet a growing body of research reveals a notable gap between
Can Smart Tools Reduce Doctor Burnout? Real Results from Primary Care
Can Smart Tools Reduce Doctor Burnout? Real Results from Primary Care Check back later for a possible video summary. How smart tools are easing the burden As administrative tasks keep piling up for primary care doctors, new technologies are being developed to
The “Pre-Pre-Diabetes” Zone: Are We Overdiagnosing Glycemic Risk?
The “Pre-Pre-Diabetes” Zone: Are We Overdiagnosing Glycemic Risk? Check back later for a possible video summary. Abstract Recent advancements in the understanding of glycemic dysregulation have led to more sensitive criteria for diagnosing prediabetes. As a result, growing concern has emerged regarding
De-prescribing in Older Adults: Why “Less is More” is Easier Said Than Done
De-prescribing in Older Adults: Why “Less is More” is Easier Said Than Done Check back later for a possible video summary. Videos are created for most articles. Abstract The adage “less is more” has gained significant traction in modern healthcare, particularly in geriatric medicine,
Iron Study Interpretation: Why Traditional Tests Miss Functional Deficiency
Iron Study Interpretation: Why Traditional Tests Miss Functional Deficiency Check back later for a possible video summary. Videos are created for most articles. Introduction Anemia is one of the most common diseases in the world, and iron deficiency anemia is the most
