Glucagon-Like Peptide-1 Receptor Agonists and Human Fertility: Mechanisms, Evidence, and Clinical Implications Abstract Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are well established for the treatment of type 2 diabetes mellitus and obesity. Increasingly, reports suggest a possible association between GLP-1 RA use and
Tranexamic Acid in Non-Trauma Cases: The Hidden Risks You Should Know
Tranexamic Acid in Non-Trauma Cases The Hidden Risks You Should Know Introduction Tranexamic acid is a synthetic antifibrinolytic agent widely used to reduce bleeding by inhibiting plasminogen activation and fibrin degradation. Its efficacy in trauma related hemorrhage has led to broad acceptance across emergency
The Great Propofol Debate: Are We Too Dependent on a Single Drug?
The Great Propofol Debate Are We Too Dependent on a Single Drug Abstract Since its introduction into clinical practice in the 1980s, propofol has become a cornerstone of modern anesthesia and procedural sedation. Its rapid onset of action, short context sensitive half time, and predictable recovery profile
Silent Inflammation: The Hidden Driver of Multisystem Chronic Disease?
Silent Inflammation The Hidden Driver of Multisystem Chronic Disease Abstract Chronic low grade inflammation, often referred to as silent inflammation, is increasingly recognized as a persistent inflammatory state that occurs in the absence of the classical signs and symptoms associated with acute inflammation.
Rare Disease Diagnosis: The Promise of Whole-Genome Sequencing in Pediatrics
Rare Disease Diagnosis The Promise of Whole-Genome Sequencing in Pediatrics Abstract Rare diseases collectively affect millions of children worldwide and represent a significant source of morbidity, mortality, and long term disability. Although individual rare disorders have low prevalence, their cumulative impact places a substantial
Precision Endocrinology: How Genomic Testing Improves Thyroid Treatment Outcomes
Precision Endocrinology How Genomic Testing Improves Thyroid Treatment Outcomes Introduction Precision endocrinology represents a paradigm shift in the management of thyroid disorders, grounded in an expanding body of genetic and molecular evidence. Large scale genetic studies have demonstrated that approximately 57 to 71 percent
New Frontiers in Male Hypogonadism: Are We Over-Treating Low Testosterone?
New Frontiers in Male Hypogonadism Are We Over-Treating Low Testosterone Abstract Male hypogonadism has emerged as one of the most intensively debated topics in men’s health over the past two decades. Advances in laboratory testing, increased awareness of androgen deficiency, and widespread direct to consumer marketing have
Biological vs Chronological Age: Are Geriatricians Ready for ‘Aging Clocks’?
Biological vs Chronological Age: Are Geriatricians Ready for ‘Aging Clocks’? Abstract The concept of biological age versus chronological age represents a fundamental shift in how healthcare providers assess aging and age-related health risks. While chronological age measures the time elapsed since birth, biological
Bite Therapy: CAR-T vs T-Cell Engagers – Which Saves More B-ALL Patients?
Bite Therapy: CAR-T vs T-Cell Engagers – Which Saves More B-ALL Patients? Introduction Bite therapy and CAR-T cell treatments have revolutionized the management of B-cell acute lymphoblastic leukemia (B-ALL), achieving remarkable remission rates. Second-generation CD19-targeted chimeric antigen receptor T cells achieve dramatic remission
Metformin in 2025: Still the King or Time to Step Aside?
Metformin in 2025: Still the King or Time to Step Aside? Abstract Metformin has reigned as the first-line therapeutic option for type 2 diabetes mellitus for over six decades, earning its moniker as the “king” of anti-diabetic medications. As we advance through 2025, the diabetes
