Medical Alert Watch Technology: From Detection to Emergency Response in Minutes Introduction Falls represent a major public health concern among older adults, with more than one in four individuals aged 65 years and older experiencing at least one fall annually. These events are associated
Why Biomarker-Driven Treatment Fails: The Hidden Role of Histology
Why Biomarker-Driven Treatment Fails The Hidden Role of Histology Introduction Biomarker-driven treatment has fundamentally transformed oncology, ushering in an era of precision medicine in which therapeutic decisions are increasingly guided by the molecular characteristics of tumors rather than their anatomical origin alone. A
Targeting the Bone Marrow Microenvironment in Myeloma and Acute Myeloid Leukemia: Novel Therapeutic Approaches and Clinical Implications
Targeting the Bone Marrow Microenvironment in Myeloma and Acute Myeloid Leukemia Novel Therapeutic Approaches and Clinical Implications Abstract The bone marrow microenvironment is increasingly recognized as a central determinant in the initiation, progression, and therapeutic resistance of hematologic malignancies, particularly multiple myeloma and acute myeloid leukemia
Prediabetes Management in Family Practice: Comparative Effectiveness of Lifestyle Intervention, Metformin, and Anti-Obesity Pharmacotherapy
Prediabetes Management in Family Practice Comparative Effectiveness of Lifestyle Intervention, Metformin, and Anti-Obesity Pharmacotherapy Abstract Prediabetes represents a critical window for intervention in the trajectory toward type 2 diabetes mellitus, offering family physicians an opportunity to prevent or significantly delay disease onset. With global
Postoperative Delirium and Brain Health: Can the Anesthesiologist Prevent Dementia?
Postoperative Delirium and Brain Health Can the Anesthesiologist Prevent Dementia Abstract Postoperative delirium has emerged as a major concern in perioperative medicine, particularly among older adults undergoing surgical procedures. Characterized by an acute and fluctuating disturbance in attention, awareness, and cognition, postoperative delirium affects
CRISPR and Gene Editing in Neurodegenerative Diseases: Current Applications and Future Therapeutic Potential
CRISPR and Gene Editing in Neurodegenerative Diseases Current Applications and Future Therapeutic Potential Abstract Neurodegenerative diseases continue to pose profound challenges to modern medicine, affecting millions of individuals worldwide and contributing significantly to disability, mortality, and healthcare expenditure. Disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease,
Cefepime Neurotoxicity: Underrecognized Risk or Overblown Concern?
Cefepime Neurotoxicity Underrecognized Risk or Overblown Concern Abstract Cefepime is a fourth generation cephalosporin antibiotic that is widely utilized in clinical practice for the treatment of severe and life threatening bacterial infections, including hospital acquired pneumonia, febrile neutropenia, complicated urinary tract infections, and infections caused by
LDL Targets Below 40 mg/dL: How Low Is Too Low in 2026?
LDL Targets Below 40 mg/dL: How Low Is Too Low in 2026? Abstract PurposeThis paper evaluates the current evidence supporting the use of very low low density lipoprotein (LDL) cholesterol targets below 40 mg per deciliter in contemporary cardiovascular practice and examines whether the benefits
mRNA Vaccines in Pregnancy: Reassurance or Lingering Concerns?
mRNA Vaccines in Pregnancy: Reassurance or Lingering Concerns? Abstract This paper reviews the current body of evidence regarding the safety and effectiveness of messenger RNA COVID-19 vaccines during pregnancy and explores the broader implications for emerging mRNA vaccine platforms intended for use in pregnant populations.
The Decline of Physical Examination Skills in Internal Medicine: An Existential Threat?
The Decline of Physical Examination Skills in Internal Medicine An Existential Threat Abstract The physical examination has historically served as a central pillar of medical practice, guiding diagnostic reasoning, informing clinical decision making, and fostering meaningful physician patient relationships. For generations, proficiency in bedside examination has
