Polypharmacy at the End of Life: Why Are So Many Patients Still Taking Statins and Bisphosphonates?

Evidence-based clinical review Polypharmacy at the End of Life: Why Are So Many Patients Still Taking Statins and Bisphosphonates? A prognosis- and goals-based approach to preventive medications, with important exceptions for recent ASCVD, high fracture risk, and active cancer indications Estimated

Perioperative Antibiotic Prophylaxis in 2026: Shorter, Narrower, Smarter, and Still Controversial

Evidence-based clinical review Perioperative Antibiotic Prophylaxis in 2026 Shorter, Narrower, Smarter, and Still Controversial Estimated reading time: 15 minutes Abstract Background Perioperative antibiotic prophylaxis prevents surgical site infection only when the right drug reaches the operative

Continuous Glucose Monitoring Beyond Insulin: Evidence, OTC Systems, and Data Interpretation for Family Medicine

Evidence-based clinical review Continuous Glucose Monitoring Beyond Insulin Evidence, OTC Systems, and Data Interpretation for Family Medicine A practical framework for selecting professional, prescription, or over-the-counter CGM and converting an ambulatory glucose profile into safe clinical decisions Estimated reading time: 15 minutes

Blood-Based Colorectal Cancer Screening in Family Practice: Where Shield Fits Among FIT, Stool DNA, and Colonoscopy

Evidence-based clinical review Blood-Based Colorectal Cancer Screening in Family Practice: Where Shield Fits Among FIT, Stool DNA, and Colonoscopy A practical framework for average-risk adults who remain unscreened or decline preferred modalities Abstract Background: The U.S. Food

Small Fiber Neuropathy: When EMG Is Normal but the Patient Is Not

Evidence-based clinical review Small Fiber Neuropathy: When EMG Is Normal but the Patient Is Not A practical framework for recognizing the phenotype, confirming small-fiber dysfunction, finding treatable causes, and avoiding diagnostic overreach Abstract Background: Small fiber neuropathy

Triple Therapy for COPD: Who Benefits, Who Is at Risk for Pneumonia, and Who May Be Overtreated?

Evidence-based clinical review Triple Therapy for COPD: Who Benefits, Who Is at Risk for Pneumonia, and Who May Be Overtreated? A phenotype- and exacerbation-based approach to adding, continuing, or withdrawing inhaled corticosteroids Estimated reading time: 16 minutes

Ultrasound-Guided Central Venous Access: Is Landmark-Only Placement Now Outdated?

Evidence-based clinical review Ultrasound-Guided Central Venous Access: Is Landmark-Only Placement Now Outdated? For routine central venous catheterization, real-time ultrasound should be the default when trained operators and functioning equipment are available. Landmark-only access still has a limited contingency role. Estimated reading time:

Real-World Evidence vs Randomized Trials in Oncology: When Should Practice Change?

Evidence-based clinical review Real-World Evidence vs Randomized Trials in Oncology When Should Practice Change Estimated reading time: 15 minutes Abstract Background: Oncology increasingly relies on evidence generated outside conventional randomized controlled trials. This is particularly true