Cefepime Neurotoxicity Underrecognized Risk or Overblown Concern Abstract Cefepime is a fourth generation cephalosporin antibiotic that is widely utilized in clinical practice for the treatment of severe and life threatening bacterial infections, including hospital acquired pneumonia, febrile neutropenia, complicated urinary tract infections, and infections caused by
LDL Targets Below 40 mg/dL: How Low Is Too Low in 2026?
LDL Targets Below 40 mg/dL: How Low Is Too Low in 2026? Abstract PurposeThis paper evaluates the current evidence supporting the use of very low low density lipoprotein (LDL) cholesterol targets below 40 mg per deciliter in contemporary cardiovascular practice and examines whether the benefits
mRNA Vaccines in Pregnancy: Reassurance or Lingering Concerns?
mRNA Vaccines in Pregnancy: Reassurance or Lingering Concerns? Abstract This paper reviews the current body of evidence regarding the safety and effectiveness of messenger RNA COVID-19 vaccines during pregnancy and explores the broader implications for emerging mRNA vaccine platforms intended for use in pregnant populations.
The Decline of Physical Examination Skills in Internal Medicine: An Existential Threat?
The Decline of Physical Examination Skills in Internal Medicine An Existential Threat Abstract The physical examination has historically served as a central pillar of medical practice, guiding diagnostic reasoning, informing clinical decision making, and fostering meaningful physician patient relationships. For generations, proficiency in bedside examination has
The Great Vitamin D Debate: Optimal Levels, Supplementation, and Clinical Outcomes
The Great Vitamin D Debate Optimal Levels, Supplementation, and Clinical Outcomes Abstract Vitamin D deficiency is among the most common nutritional disorders globally, affecting an estimated one billion individuals across a wide range of ages, ethnicities, and geographic regions. Contributing factors include limited sunlight
Why Do Teens Vape? New Research Reveals Hidden Brain Changes
Why Do Teens Vape? New Research Reveals Hidden Brain Changes Introduction Despite increasing public awareness of the health risks associated with nicotine use, vaping remains highly prevalent among adolescents. According to 2024 data from the Centers for Disease Control and Prevention, 8.1 percent of
Beyond Psoriasis: Why Biologics Are Reshaping Disease-Specific Dermatology
Beyond Psoriasis: Why Biologics Are Reshaping Disease-Specific Dermatology Introduction Biologics have transformed the therapeutic landscape of chronic inflammatory dermatoses, demonstrating remarkable efficacy and safety profiles in conditions previously challenging to manage. These targeted immunomodulators have revolutionized treatment approaches for moderate-to-severe psoriasis, hidradenitis suppurativa,
Beyond Thresholds: Why Continuous Risk Assessment Improves Hypertension Treatment
Beyond Thresholds: Why Continuous Risk Assessment Improves Hypertension Treatment Introduction Hypertension treatment based solely on blood pressure thresholds may miss critical opportunities to prevent cardiovascular disease. For decades, physicians have relied on the 140/90 mm Hg cutoff to determine which patients require pharmacological
Breaking Through Pain Barriers: Latest Advances in Long-Acting Nerve Blocks
Breaking Through Pain Barriers: Latest Advances in Long-Acting Nerve Blocks Introduction How long does a nerve block last remains a crucial question in pain management, particularly as over 51 million adults in the United States—more than one in five Americans—live with chronic pain
Resistant Starch and Short-Chain Fatty Acids: A Comprehensive Review of Physiologic Mechanisms
Resistant Starch and Short-Chain Fatty Acids: A Comprehensive Review of Physiologic Mechanisms and Clinical Relevance Comprehensive Guide Abstract Resistant starch represents a distinct category of dietary carbohydrate that escapes digestion in the small intestine and undergoes fermentation by colonic bacteria. This process generates short-chain fatty
