Rare Disease Diagnosis The Promise of Whole-Genome Sequencing in Pediatrics Abstract Rare diseases collectively affect millions of children worldwide and represent a significant source of morbidity, mortality, and long term disability. Although individual rare disorders have low prevalence, their cumulative impact places a substantial
Precision Endocrinology: How Genomic Testing Improves Thyroid Treatment Outcomes
Precision Endocrinology How Genomic Testing Improves Thyroid Treatment Outcomes Introduction Precision endocrinology represents a paradigm shift in the management of thyroid disorders, grounded in an expanding body of genetic and molecular evidence. Large scale genetic studies have demonstrated that approximately 57 to 71 percent
New Frontiers in Male Hypogonadism: Are We Over-Treating Low Testosterone?
New Frontiers in Male Hypogonadism Are We Over-Treating Low Testosterone Abstract Male hypogonadism has emerged as one of the most intensively debated topics in men’s health over the past two decades. Advances in laboratory testing, increased awareness of androgen deficiency, and widespread direct to consumer marketing have
Biological vs Chronological Age: Are Geriatricians Ready for ‘Aging Clocks’?
Biological vs Chronological Age: Are Geriatricians Ready for ‘Aging Clocks’? Abstract The concept of biological age versus chronological age represents a fundamental shift in how healthcare providers assess aging and age-related health risks. While chronological age measures the time elapsed since birth, biological
Bite Therapy: CAR-T vs T-Cell Engagers – Which Saves More B-ALL Patients?
Bite Therapy: CAR-T vs T-Cell Engagers – Which Saves More B-ALL Patients? Introduction Bite therapy and CAR-T cell treatments have revolutionized the management of B-cell acute lymphoblastic leukemia (B-ALL), achieving remarkable remission rates. Second-generation CD19-targeted chimeric antigen receptor T cells achieve dramatic remission
Metformin in 2025: Still the King or Time to Step Aside?
Metformin in 2025: Still the King or Time to Step Aside? Abstract Metformin has reigned as the first-line therapeutic option for type 2 diabetes mellitus for over six decades, earning its moniker as the “king” of anti-diabetic medications. As we advance through 2025, the diabetes
Epigenetics and Brain Plasticity: Can We Rewrite the Neurological Code?
Epigenetics and Brain Plasticity: Can We Rewrite the Neurological Code? Introduction More than half of children are estimated to experience at least one form of early-life stress, contributing to 30–40% of all mood, drug, and psychiatric disorders. Neural plasticity, a remarkable characteristic of
Anemia of Chronic Disease: Unravelling New Pathways Beyond Iron
Anemia of Chronic Disease: Unravelling New Pathways Beyond Iron Abstract Anemia of chronic disease (ACD) represents the second most common form of anemia worldwide, affecting millions of patients with underlying inflammatory conditions. Traditionally understood as a disorder primarily involving disruption of iron metabolism, recent
Hidden Crisis: Why Sarcopenia Treatment Matters More Than You Think in 2025
Hidden Crisis: Why Sarcopenia Treatment Matters More Than You Think in 2025 Introduction Sarcopenia treatment represents a critical healthcare priority as the prevalence of this age-related muscle wasting condition reaches alarming levels. The economic burden of sarcopenia in the United States was approximately
Is Type 2 Diabetes Reversible? New Research Challenges Medical Consensus
Is Type 2 Diabetes Reversible? New Research Challenges Medical Consensus Introduction The concept of type 2 diabetes reversibility represents a profound shift in the understanding and management of a condition long regarded as chronic and progressive. Diabetes remains a major global health burden, with prevalence
