Beyond Psoriasis: Why Biologics Are Reshaping Disease-Specific Dermatology Introduction Biologics have transformed the therapeutic landscape of chronic inflammatory dermatoses, demonstrating remarkable efficacy and safety profiles in conditions previously challenging to manage. These targeted immunomodulators have revolutionized treatment approaches for moderate-to-severe psoriasis, hidradenitis suppurativa,
Beyond Thresholds: Why Continuous Risk Assessment Improves Hypertension Treatment
Beyond Thresholds: Why Continuous Risk Assessment Improves Hypertension Treatment Introduction Hypertension treatment based solely on blood pressure thresholds may miss critical opportunities to prevent cardiovascular disease. For decades, physicians have relied on the 140/90 mm Hg cutoff to determine which patients require pharmacological
Breaking Through Pain Barriers: Latest Advances in Long-Acting Nerve Blocks
Breaking Through Pain Barriers: Latest Advances in Long-Acting Nerve Blocks Introduction How long does a nerve block last remains a crucial question in pain management, particularly as over 51 million adults in the United States—more than one in five Americans—live with chronic pain
Resistant Starch and Short-Chain Fatty Acids: A Comprehensive Review of Physiologic Mechanisms
Resistant Starch and Short-Chain Fatty Acids: A Comprehensive Review of Physiologic Mechanisms and Clinical Relevance Comprehensive Guide Abstract Resistant starch represents a distinct category of dietary carbohydrate that escapes digestion in the small intestine and undergoes fermentation by colonic bacteria. This process generates short-chain fatty
Coronary Artery Calcium–Guided Prevention and Microbiome-Centered Nutrition
Coronary Artery Calcium–Guided Prevention and Microbiome-Centered Nutrition: A Physician-Focused Review Integrating the Clinical Framework of William Davis, MD Quick Summary CAC is most useful when you’re on the fence. In borderline/intermediate-risk patients—or when risk markers conflict—CAC can clarify preventive intensity and improve
Preventing the Next Pandemic: Critical Insights from SARS-CoV-2 Surveillance Systems
Preventing the Next Pandemic Critical Insights from SARS-CoV-2 Surveillance Systems Introduction Preventing the next global pandemic requires a clear understanding of the profound and multifaceted impact of SARS-CoV-2, the virus responsible for COVID-19. Since its emergence, SARS-CoV-2 has infected millions of people worldwide and caused
Noninvasive Prenatal Testing (NIPT): What’s Next After Aneuploidy?
Noninvasive Prenatal Testing (NIPT) What’s Next After Aneuploidy Abstract Noninvasive prenatal testing has fundamentally reshaped prenatal screening by enabling highly accurate detection of fetal chromosomal abnormalities through analysis of cell free fetal DNA circulating in maternal blood. Since its clinical introduction, NIPT has been widely
Expert Guide: Managing Cardiovascular-Kidney-Metabolic Syndrome in Clinical Practice
Expert Guide Managing Cardiovascular-Kidney-Metabolic Syndrome in Clinical Practice Introduction Cardiovascular kidney metabolic syndrome represents one of the most urgent and complex health challenges of the modern era. The global burden of cardiovascular disease continues to rise at an alarming pace, with prevalence increasing from approximately
Beyond the Golden Hour in Trauma Care: New Evidence Questions Traditional Time Windows
Beyond the Golden Hour in Trauma Care New Evidence Questions Traditional Time Windows Introduction The concept of the golden hour has long been a foundational principle in trauma and emergency medicine, emphasizing the urgency of definitive care within the first 60 minutes following
Are We Overtreating Early Rheumatoid Arthritis in the Biologic Era?
Are We Overtreating Early Rheumatoid Arthritis in the Biologic Era Abstract The introduction of biologic disease modifying antirheumatic drugs has fundamentally reshaped the management of rheumatoid arthritis over the past two decades. These agents, in combination with conventional synthetic therapies and treat to target strategies, have significantly
