Pharmacokinetics – Calculators, Tools, Etc.

Calculators

Adjusted body weight (AjBW) and (IBW) calc Aminoglycosides and Vanco (Original calc)

Clearance Equations

CKD Epidemiology Collaboration (CKD-EPI) Creatinine Clearance Adult Creatinine Clearance- Pediatric CrCL- Obese Patient (Salazar and Corcoran) Creatinine Clearance – Multi-calc hot CrCL – Unstable Renal Function MULTI-calc CrCL -IDMS-traceable MDRD Study Equation Creatinine Clearance – Multi-calc 2012 EDITION A new beta multi-calc was created with specialized handling of patients with a height below 60 inches. It also contains all of the functionality of the standard multi-calculator as well as the calculation of the GFR Creatinine Clearance / GFR- Multi-calc (height adjustment) Cytochrome P450 Analysis Tool

Dosing by levels

Dosing by levels (Full) Dosing by levels – pharmacokinetics (quick) Non-Steady State kinetics

Pharmacokinetics

Pharmacokinetics -Multiple Ke (Advanced version) Pharmacokinetics 2010 – 2011 Pharmacokinetic dosing -aminoglycosides/Vanco Original program
Vancomycin AUC Dosing Calculator

Trough Calculators

Trough drawn early? -Estimation Tool based on entered Kel
——— This new program can be used to determine when to administer the next dose of vancomycin after a supratherapeutic trough is obtained. An estimated elimination rate constant is generated from the creatinine clearance which is then used to determine the timing of the next dose based on the desired target trough concentration.Vancomycin -Timing of next dose based on estimated Ke value
——— Use this program if the vancomcyin level is drawn early and you want to estimate the actual trough just before the next dose to determine if the current regimen is appropriate Vancomycin – Predicted Trough-Level drawn early

Vancomycin – Single-level dosing

Vancomycin SINGLE Level-(dosing by levels) Original calc ledIf you would like to enter the time since the last dose was given, use this version.This new version may be especially useful if the trough was drawn late and the next dose was delayed. Example: current regimen vanco 1 gram q12h. Trough was drawn 12.5 hours after the last dose.Vancomycin single-level – dose infused early or lateThe GlobalRPh vancomycin single-level calculator uses the Vd recommended in Bauer’s text: 0.7 L/kg. Use the advanced version if you wish to manipulate this value.Vancomycin single level – Advanced version

Aminoglycosides /Vancomycin Empiric Dosing

Aminoglycosides/ Vancomycin Calculator (Original calculator) Advanced Aminoglycoside – Vancomycin Multiple ke calculator Advanced Pharmacokinetic Dosing

Dosing By Levels

Dosing by levels (Full) – Enter two levels and associated times Dosing by levels(quick) – Enter two levels and the time between levels Dosing by levels(SINGLE) – Vancomycin -single level analysis hot
——– Non-Steady State kinetics ——–

New calculators

Vancomycin: Based on input from one of our visitors (below), a new vancomycin program was created. This new program can be used to determine when to administer the next dose of vancomycin after a supratherapeutic trough is obtained. An estimated elimination rate constant is generated from the creatinine clearance which is then used to determine the timing of the next dose based on the desired target trough concentration.Another version of this program was created to generate an estimated vancomycin kel value based on the creatinine clearance. Use this program if the vancomcyin level is drawn early and you want to estimate the actual trough just before the next dose to determine if the current regimen is appropriate – link to new program..) Trough calculator: The following trough calculator used to predict the actual trough value if the level is drawn early.

Creatinine Clearance Calculators

CRCL – AdultMulti-calc – Multiple clearance models calculated simultaneously hot CrCl – Pediatric – Three common pediatric clearance calculations calculated simultaneously Creatinine clearance – Unstable Renal Function MULTI-calc
Creatinine clearance -IDMS-traceable MDRD Study Equation Creatinine Clearance- Obese Patient (Salazar and Corcoran) Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Calculatornew icon
Creatinine ClearanceMulti-calc 2012 EDITION hot

Heparin Dosing

Heparin Dosing Heparin Dosing- MC Dallas Hosp Heparin Dosing- Affinity Medical
Heparin Dosing – Detroit VAMC

Other

APACHE II calculator Digoxin Dosing Calc Phenytoin Dosing Calc
Renal Dosing Protocols Warfarin Dosing Calc
A warfarin maintenance adjustment tool was created. This new tool has a built-in database of warfarin maintenance regimens from 5 to 100mg.

Drug Tables / Other

Clinical concerns- Geriatric patient Drug-Food Interactions Drug- Grapefruit Interactions
Ideal body weight (IBW) AND Adjusted body weight calc Pharmacokinetics – Review Cytochrome P450 Analysis Tool
First order kinetics equation derivation Therapeutic Drug Levels

Alphabetical Listing of individual drugs

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Common LAB Values  Renal Dosing