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Advanced Pharmacokinetic Dosing AUC Calculator

For Vancomycin AUC related dosing only, please use the following Calculator >>       Help support the site.  We still have the holiday subscription pricing option ($49.95 for one year).  Faster loading. Ad-Free. Superior navigation.
Patient: Location:
Age: Sex: Serum Creatinine:
: Weight:

Clearance method

Desired Peak
: mcg/ml   Desired Trough: mcg/ml

Volume of distribution:led  L/kg
Usual range: aminoglycosides: 0.25 - 0.35.   Vanco: 0.65 - 0.9

Infusion time (ti): led    Additional Info

Optional section:

Select elimination rate constant (Ke) calculation method: Info
Ke = 0.00083 x CRCL + 0.0044 Usual Vd reported: 0.9 L/kg. (0.7 - 0.9 L/kg) Ref: 3,4,5
Clearance method: CL (L/hr) = CrCl (ml/min) x 0.06. Ke = Vanco CL/Vd. Usual Vd: 0.7L/kg. Ref: 6
Ke (hr-1) = [(0.695[(CrCl mL/min)/TBW kg] + 0.05) x 0.06] / Vd factor ] Usual Vd: 0.7L/kg. Ref: 2

New option based on input from clinicians - general assumption, adjusted body weight may be used in the morbidly obese patients receiving vancomycin: Historically actual or total is used in all cases.
Use Adjusted body weight or Use Actual (total) weight for vanco dosing.

Clearance method: CL (L/hr) = CrCl (ml/min) x 0.06. Ke = CL/Vd. Ref: 5,6
Ke = 0.00293(CrCl) + 0.014 Ref: 1,4
Ke (hr-1) = (0.0024 x CrCl) + 0.01 Ref: 5

Loading Dose - Aminoglycosides


This latest version is based on a comprehensive review of the most recent pharmacokinetic textbooks. Some of the sources used are listed here
  1. Bauer LA. The Aminoglycoside Antibiotics. In Bauer LA, ed. Applied Clinical Pharmacokinetics. 2nd ed. New York, NY: McGraw Hill Medical; 2008:97-206.

  2. Bauer LA. Vancomycin. In Bauer LA, ed. Applied Clinical Pharmacokinetics. 2nd ed. New York, NY: McGraw Hill Medical; 2008:207-298.

  3. Burton ME, Shaw LM, Schentag JJ, Evans WE. Applied Pharmacokinetics & Pharmacodynamics: Principles of Therapeutic Drug Monitoring. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2006.

  4. DiPiro JT, Spruill WJ, Wade WE, Blouin RA, Pruemer JM. Concepts in Clinical Pharmacokinetics, (5th Edition) 2010. American Society of Health Systems Pharmacist, Bethesda, MD.

  5. Murphy JE. Aminoglycosides. In: Murphy JE, ed. Clinical Pharmacokinetics, 4th ed. Bethesda, MD: American Society of Health-System Pharmacists, 2008:27-60.

  6. Winter ME. Basic clinical pharmacokinetics. 5th ed. Baltimore: Lippincott Williams and Wilkins; 2010.
  7. Winter MA, Guhr KN, Berg GM. Impact of various body weights and serum creatinine concentrations on the bias and accuracy of the Cockcroft-Gault equation. Pharmacotherapy 2012; 32: 604-612 [PMID: 22576791 DOI: 10.1002/j.1875-9114.2012.01098.x]

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Quotes: [Largest study so of 3678 patients]
Regarding Salazar equation: This equation, however, was not consistently shown in studies to be a superior predictor of renal function. It is not widely used in clinical practice and has not been validated in pharmacokinetic studies. In addition, the Salazar-Corcoran equation is not recognized by the National Kidney Foundation.

Regarding CG -LBW equation: Our findings do not support those conclusions and are different from a recent investigation of Clcr in 54 morbidly obese patients that found that adjusting an obese patient's weight to a fat-free weight or lean body weight predicted a Clcr calculated with the C-G equation without bias. Notably, our study included 2065 obese or morbidly obese patients, far more than other published studies. 

Conclusions: An unbiased C-G Clcr can be calculated using actual body weight in underweight patients and ideal body weight in patients of normal weight. Using ABW0.4 for overweight, obese, and morbidly obese patients appears to be the least biased and most accurate method for calculating their C-G Clcr. Rounding Scr in patients with low Scr did not improve accuracy or bias of the Clcr calculations.  top of page

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ADVANCED Pharmacokinetics 2010 – 2011