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Vancomycin - Predicted Trough Value - Level drawn early

This program can be used to determine if the current regimen is appropriate based on an early (supratherapeutic) vancomycin level which is used along with an estimated elimination rate constant to determine the level just before the next dose.

(Note: if a random supratherapeutic vancomcyin level is drawn and you need to determine when to give the next dose based on a desired target trough level - use the following program.   Overview: An estimated elimination rate constant is generated from the creatinine clearance which is then used to determine the timing of the next dose based on the target trough concentration.)
Estimated creatinine clearance (mL/min)
Current trough (early supratherapeutic value):   mcg/mL
Number of hours trough was drawn PRIOR to next dose  hrs.
(Note: may use decimals e.g. 3.5 hrs.  This time will be used to calculate the estimated trough value just before the next dose is due.)

Reference



Determination of Vancomycin Ke:
Matzke GR, McGroy RW, Halstenson CE et al. Pharmacokinetics of vancomycin in patients with various degrees of renal function. Antimicrob Agents Chemother. 1984; 25:433-437.
Matzke (Ke) = 0.00083(CLcr) + 0.0044



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Trough Calculators


Allows the user to estimate the actual (extrapolated) trough based on the elimination rate constant and the number of hours the level was drawn before the next scheduled dose. A supratherapeutic level may be actually therapeutic if it was drawn just before the next dose. Trough drawn early? -Estimation Tool based on entered Kel
This new program can be used to determine when to administer the next dose of vancomycin after a supratherapeutic trough is obtained. An estimated elimination rate constant is generated from the creatinine clearance which is then used to determine the timing of the next dose based on the desired target trough concentration.
Vancomycin -Timing of next dose based on estimated Ke value

Use this program if the vancomcyin level is drawn early and you want to estimate the actual trough just before the next dose to determine if the current regimen is appropriate Vancomycin – Predicted Trough-Level drawn early

Dosing by levels


Dosing by levels (Full) Dosing by levels – pharmacokinetics (quick) Non-Steady State kinetics

Pharmacokinetics


Pharmacokinetics -Multiple Ke (Advanced version)Pharmacokinetic dosing -aminoglycosides/Vanco Original program

Vancomycin – Single-level dosing


Vancomycin SINGLE Level-(dosing by levels) Original calc led
If you would like to enter the time since the last dose was given, use this version. This new version may be especially useful if the trough was drawn late and thenext dose was delayed. Example: current regimen vanco 1 gram q12h. Trough wasdrawn 12.5 hours after the last dose.Vancomycin single-level – dose infused early or late

The GlobalRPh vancomycin single-level calculator uses the Vd recommended in Bauer’s text: 0.7 L/kg. Use the advanced version if you wish to manipulate this value.Vancomycin single level – Advanced version

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user’s use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read the disclaimer