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Vancomycin -Timing of next dose based on estimated Ke value

This program can be used to determine when to administer the next dose of vancomycin after a supratherapeutic trough is obtained.  An estimated elimination rate constant is generated from the creatinine clearance which is then used to determine the timing of the next dose based on the desired target trough concentration.

(Note: if the vancomcyin level is drawn early and you want to estimate the actual trough just before the next dose to determine if the current regimen is appropriate - use the following program.)
Estimated creatinine clearance (mL/min)
Current trough:   mcg/mL
Desired trough target  (lower concentration)  mcg/mL


Determination of Vancomycin Ke:
Matzke GR, McGroy RW, Halstenson CE et al. Pharmacokinetics of vancomycin in patients with various degrees of renal function. Antimicrob Agents Chemother. 1984; 25:433-437.
Matzke (Ke) = 0.00083(CLcr) + 0.0044


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