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Pharmacokinetic Dosing by Levels - Aminoglycosides/ Vancomycin


This program will calculate the rate elimination constant (kel), the half-life and the volume of distribution from reported levels. Based on the desired peak and trough the program will then generate a new regimen (dose and interval) to produce the desired levels.
Additional information (review) can be found here. Also check out the quick version if less data is available or our non-steady state calculator. Vanco specific - single level dosing.
Patient:     Location:
Gender:      Drug:
Weight:      Height:   
Peak level obtained:     Number hours post dose
Trough level obtained:   Number hours post dose:
Current dose being given     Current dosing interval:
Current infusion time (hrs):
Desired peak:   mcg/ml     Desired trough:    mcg/ml

Sample problem to aid filling out the table above

Patient is receiving Gentamicin 120mg IVPB q8h. Infusion time is 30 minutes. A peak is drawn 1 hour after the start of the infusion and a trough is drawn 5 hours after the start of the infusion (note the entries below). The program will take into account the infusion time when calculating the actual peak (do not subtract the infusion time from the number of hours post dose). This program assumes that information provided is based on steady state. If you were to calculate these values by hand, the actual Cmax would occur at the end of the infusion. In this example (t)=  1- 0.5 = 0.5. The Cmin calculation would use a time value of (8 - 5 = 3 hours).
Pharmacokinetic

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user’s use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read the disclaimer