Critical Care

Internal Medicine Sections Critical Care
GlobalRPh Clinical Reference Library

Critical Care & ICU Clinical Resource Center

Critical-care calculators, airway and oxygenation tools, hemodynamic support, vasopressors, acid-base and electrolyte management, renal and nutrition resources, toxicology support, sedation and delirium references, sepsis material, and current GlobalRPh ICU articles.

ICU & airway tools Shock & hemodynamics Current ICU articles Internal Medicine Sections
Primary audience: physicians, pharmacists, nurses, advanced practice clinicians and other healthcare professionals involved in intensive care, emergency stabilization and high-acuity pharmacotherapy.

Clinical framework

Critical care requires integrated, multidomain assessment

ICU care frequently requires simultaneous assessment of airway protection, oxygenation and ventilation, perfusion, shock phenotype, neurologic status, kidney function, fluid and electrolyte balance, infection, sedation, delirium, nutrition, medication exposure and evolving goals of care. Clinical decision support should therefore integrate these domains rather than present isolated calculations without their physiologic and therapeutic context.

We organize our established ICU calculators, drug references and clinical resources according to common critical-care problems. We also surface resources that were less visible in our earlier portal, including rapid-sequence intubation, Glasgow Coma Scale assessment, current ICU reviews and direct access to contemporary society guidance.

  • Airway & oxygenation
  • Mechanical ventilation
  • Shock & perfusion
  • Sepsis & infection
  • Acid-base & electrolytes
  • Renal function & fluids
  • Sedation, pain & delirium
  • Nutrition & metabolic support
Critical-Care Patient Surrounded By Intensive Monitoring Equipment

Core ICU assessment

Severity, neurologic status and bedside physiology

Severity & neurologic assessment

Perfusion & oxygen delivery

General ICU support

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Airway, oxygenation & respiratory support

From emergency airway management to ARDS resources

The older portal included oxygenation equations but did not make the existing RSI tool or current respiratory-support guidance easy to reach.

Airway & post-intubation support

Oxygenation calculations

Official respiratory guidance

Hemodynamics, shock & vasoactive therapy

Perfusion assessment and cardiovascular support

Vasoactive medications

Cardiovascular calculations & anticoagulation

Related GlobalRPh reading

Shock management should be guided by etiology and serial reassessment rather than a single blood-pressure target or calculator output. Use current sepsis, cardiac, trauma, and institution-specific protocols when choosing fluids, vasoactive therapy, monitoring, and escalation.
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Acid-base, fluids & electrolytes

Core ICU calculation tools

Acid-base analysis

Water & sodium

Electrolyte replacement

Several of our long-standing electrolyte calculators contain older background references. We retain the underlying calculation tools where they remain useful; however, clinicians should verify current correction limits, replacement strategies and monitoring recommendations before bedside application.

Sepsis, infection & antimicrobial support

Current sepsis guidance and antimicrobial decision support

We prioritize current society guidance for sepsis and critical infection while retaining selected established infectious-disease resources for continuity. Resources with older clinical frameworks are identified for focused review and modernization.

Current sepsis guidance

Antimicrobial & pharmacy support

Established infection resources undergoing review

We retain these established resources for continuity while we re-verify their clinical content against contemporary sepsis, antimicrobial and therapeutic drug-monitoring guidance during individual-page modernization.
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Pain, sedation, delirium & ICU liberation

Medication support plus contemporary delirium resources

Sedation & neuromuscular blockade

Delirium & sedative stewardship

SCCM current resources

Renal function, fluids & nutrition

Kidney support, energy requirements and parenteral nutrition

Renal assessment & dosing

Fluid & electrolyte support

Nutrition & energy

Critical illness can make creatinine-based renal estimates and older predictive energy equations less reliable. Treat these tools as decision support and confirm dosing, kidney trajectory, nutrition strategy, and monitoring using the patient’s current clinical course and contemporary standards.
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Toxicology, antidotes & rescue therapies

Critical poisoning and emergency pharmacotherapy resources

Toxicology tools

Rescue & vascular access

Emergency cardiovascular support

GlobalRPh critical-care article library

Current ICU, resuscitation, sepsis and trauma reviews

Our earlier Critical Care portal surfaced only a limited selection of articles. We now include a broader set of recent GlobalRPh reviews relevant to intensive care, resuscitation, sepsis, trauma, delirium and other high-acuity clinical topics.

2026

REBOA in Non-Trauma Cardiac Arrest: Heroic Rescue or Futile Effort? Resuscitation • Refractory cardiac arrest • Critical care The New Face of Delirium: Sedative Stewardship and Nonpharmacologic Protocols ICU delirium • Sedation • Nonpharmacologic care Intravenous Lipid Rescue: Why It’s Saving Lives Far Beyond Local Anesthetic Toxicity Toxicology • Cardiovascular collapse • Rescue therapy AI-Driven Prognostic Models in Traumatic Brain Injury Neurocritical care • TBI • Prognostication Hypotension Prediction Index and Machine Learning: Game Changer or Gimmick? Hemodynamics • Perioperative critical care • Predictive monitoring Beyond the Golden Hour in Trauma Care Trauma • Resuscitation • Systems of care
2025

The “Code Sepsis” Fatigue: When Protocols Collide With Clinical Judgment Sepsis • Protocols • Clinical judgment Why Critical Care Anesthesiologists Are Essential for Modern ECMO Management ECMO • Critical care • Anesthesiology Mechanical CPR Devices: Worth the Cost? Cardiac arrest • Mechanical CPR • Resuscitation Sepsis-3 vs CMS Core Measures: Which Definition Should You Use? Sepsis definitions • Quality measures • Critical care Thrombocytopenia in the ICU: Essential Guide for Clinical Hematologists Thrombocytopenia • ICU hematology • Differential diagnosis Mortality in ICU Patients Linked to Blood Glucose Levels Critical illness • Glycemia • Outcomes
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Current external clinical standards

Current society guidance integrated with our critical-care resources

Critical-care recommendations may change more rapidly than static calculator content. We provide direct access to current sepsis, sedation/delirium, resuscitation and respiratory guidance while we progressively review and update our individual Critical Care resources.

Surviving Sepsis Campaign – Adult Guidelines 2026 Society of Critical Care Medicine / Surviving Sepsis Campaign Open official guidance
SCCM Focused PADIS Guideline Update Pain, agitation/sedation, delirium, immobility and sleep disruption in adult ICU patients Open official guidance
SCCM ICU Liberation A-F Bundle Structured ICU care focused on pain, awakening/breathing trials, sedation, delirium, mobility and family engagement Open ICU Liberation resources
AHA CPR & ECC Guidelines Current resuscitation-science guideline hub and adult advanced life-support guidance Open AHA guideline hub
ATS/ESICM/SCCM Mechanical Ventilation in Adult ARDS Official guideline implementation resources for invasive mechanical ventilation in ARDS Open official guidance
ERS/ATS Noninvasive Ventilation for Acute Respiratory Failure Official implementation resources for noninvasive ventilatory support Open official guidance

Clinical content modernization

Established Critical Care resources prioritized for contemporary review

We retain these resources because they continue to support established clinical workflows and longstanding internal links. We have prioritized them for focused evidence, terminology, labeling and guideline review before presenting them as contemporary protocol-level guidance.

Priority resource reviews

  • ACLS: our earlier Critical Care portal identified the linked ACLS resource as based on previous 2010 guidance. We now link directly to the current AHA guideline hub and have prioritized the individual GlobalRPh ACLS resource for formal updating.
  • Sepsis – Unknown Source: we retain this resource for continuity and plan to update antimicrobial strategy, terminology, therapeutic monitoring and supporting references in relation to current sepsis guidance.
  • Ventilator-Associated Pneumonia: we plan to update antimicrobial selection, resistance-risk assessment, therapeutic drug monitoring and current pneumonia guidance.
  • Vasopressin in Shock: we will reconcile our established discussion with contemporary shock and sepsis recommendations.
  • Creatinine Clearance Multi-Calc: we retain this calculator for drug-dosing workflows while prioritizing review of historical MDRD/CKD-EPI formulations and older CKD staging material.
  • Hypertonic Saline / Hyponatremia tools: we plan to preserve the useful calculation framework while updating correction-limit guidance and supporting references.
  • Ireton-Jones ICU Energy Equations: we retain this established predictive method while reviewing its role within contemporary critical-care nutrition practice.
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Supporting resources & archives

Continue exploring GlobalRPh critical-care content

Drug tables

Adjacent specialty portals

Evidence & general clinical tools

Browse Critical Care Calculators Browse Critical Care Articles GlobalRPh Video Library
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Clinical use: Our calculators, dosing tables, historical protocols, drug references and educational material are intended to support, not replace, current guidelines, institutional protocols, pharmacist and physician verification, independent calculation checks and professional judgment. Critical-care decisions should be based on the patient’s evolving physiology and clinical context.

Return to Internal Medicine Sections  |  Critical Care Calculators  |  IV Dilutions  |  Renal Dosing  |  Common Lab Values

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Alphabetical Listing of individual drugs

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Common LAB Values  Renal Dosing

Internal Medicine Sections

Critical Care