Nephrology, Kidney Function & Renal Dosing Resource Center
Creatinine-clearance and GFR tools, albuminuria and proteinuria resources, CKD risk assessment, renal-drug dosing, acute kidney injury support, electrolytes and acid-base tools, CKD-mineral bone disease, anemia in CKD, glomerular disease, dialysis and transplant resources, and current GlobalRPh nephrology articles.
Clinical background
Modern kidney assessment requires more than a single serum creatinine
Kidney function is interpreted differently depending on the clinical question. Estimated GFR supports CKD detection, staging and prognosis; creatinine clearance remains relevant to many medication labels and pharmacokinetic workflows; cystatin C can improve confidence when creatinine is less reliable; and urine albumin provides prognostic information that eGFR alone can miss. Acute kidney injury adds a further challenge because serum creatinine may not be at steady state.
This updated portal separates these tasks rather than treating all kidney equations as interchangeable. It preserves GlobalRPh’s established creatinine-clearance calculators while identifying the older race-based CKD-EPI and MDRD pages as update priorities. It also elevates albuminuria, kidney-failure risk, CKD treatment, AKI, mineral-bone disease, anemia, glomerular disease, dialysis and medication stewardship into distinct clinical sections.
- eGFR & creatinine clearance
- Albuminuria & proteinuria
- Chronic kidney disease
- Acute kidney injury
- Electrolytes & acid-base
- CKD-mineral bone disorder
- Anemia in CKD
- Dialysis & transplantation
Albuminuria as a Vital Sign
GlobalRPh’s 2026 urine-ACR review reflects a major shift in kidney-risk assessment: eGFR and albuminuria are complementary rather than competing measures. Persistent albuminuria can identify increased kidney and cardiovascular risk even when filtration remains relatively preserved.
Chronic Kidney Disease in the Non-Diabetic Patient
This 2026 GlobalRPh review brings contemporary CKD management into the portal, including race-free GFR assessment, cystatin C, albuminuria, SGLT2 inhibitors, renin-angiotensin system therapy, blood-pressure management and cause-specific evaluation.
Kidney function & medication dosing
Creatinine clearance, eGFR and the importance of using the right equation
GlobalRPh has one of its deepest calculator collections in renal function. These tools are retained, but the revised portal now distinguishes conventional drug-dosing creatinine-clearance methods from modern CKD eGFR assessment.
Adult creatinine clearance
Older adult eGFR equations – retained during update
Pediatric kidney function
eGFR and creatinine clearance should not be treated as identical values
CKD staging, kidney-risk prediction and medication dosing can use different kidney-function measures. Some drug labels were developed using Cockcroft-Gault creatinine clearance, while newer labeling and clinical guidance may use eGFR. The appropriate renal-function estimate should follow the drug label, clinical context and the reliability of the available biomarkers rather than automatically substituting one equation for another.
Chronic kidney disease detection & risk
eGFR, albuminuria, proteinuria and kidney-failure prediction
KDIGO’s current CKD framework combines filtration and albuminuria rather than relying on serum creatinine alone. This section gives urine ACR/protein assessment a much more prominent role than the old Nephrology portal.
Urine protein / albumin resources
Current CKD risk framework
GlobalRPh current CKD reading
CKD treatment & cardiorenal protection
RAS inhibition, SGLT2 inhibitors, blood pressure and metabolic risk
Modern CKD treatment increasingly centers on therapies that reduce kidney and cardiovascular risk, not merely correction of serum creatinine or laboratory abnormalities.
Renin-angiotensin & blood pressure
SGLT2 & metabolic therapy
Albuminuria / mineralocorticoid receptor therapy
Acute kidney injury & unstable renal function
When steady-state equations become unreliable
GlobalRPh has a dedicated unstable-renal-function multi-calculator, which is important because conventional creatinine-based equations assume or perform best near steady state.
Unstable kidney function
Current AKI guideline status
- KDIGO AKI / AKD Guideline Resource Center
- Critical Care / ICU Portal
- Toxicology / Nephrotoxin Crossover
Medication stewardship in AKI
Electrolytes, fluids & acid-base
Renal physiology crossover with the GlobalRPh Electrolytes portal
Acid-base
Potassium, magnesium & phosphate
CKD-mineral & bone disorder
Phosphate binders, vitamin D, calcium and secondary hyperparathyroidism
GlobalRPh renal-failure drug table
Current CKD-MBD guidance
Why this section needs updating
The current Renal Failure Agents page contains older calcium-phosphate-product thresholds, aluminum-hydroxide instructions and legacy dialysis-era medication language. We plan to modernize this table against current CKD-MBD guidance and current product labeling.
Anemia & iron deficiency in CKD
Current 2026 KDIGO guidance plus GlobalRPh iron tools
Anemia management is a major nephrology update area because KDIGO published a new Anemia in CKD guideline in 2026.
Iron assessment & deficit tools
Products & contemporary interpretation
Current kidney guidance
Glomerular, immune & genetic kidney disease
Current KDIGO disease-specific resources
The existing portal barely represents glomerular disease despite major recent guideline updates. These resources provide a current pathway while we build more GlobalRPh disease-specific content.
IgA & glomerular disease
Lupus / vasculitis
ADPKD & pediatric nephrotic syndrome
Advanced CKD, dialysis & kidney transplantation
Medication burden, renal replacement therapy and patient-centered decision-making
Dialysis & advanced CKD
GlobalRPh renal dosing
Large medication-by-medication renal dosing database
Renal dosing is one of GlobalRPh’s foundational resources. The database contains a large alphabetical list of medications requiring kidney-function review and remains a major reason to keep creatinine-clearance and pharmacokinetic tools closely connected to Nephrology.
High-use renal-dose crossovers
Modernization note
The current database still contains a number of obsolete or discontinued drugs and older renal thresholds. We plan to preserve the alphabetical structure while systematically verifying currently marketed agents, current labeling, dialysis removal, CRRT considerations and the renal measure used by each product label.
GlobalRPh nephrology article library
Current and established kidney-related reading
The old portal surfaced only the 2024 fenofibrate article. The Nephrology category now has a much broader 2025–2026 clinical library.
2026
GlobalRPh nephrology & electrolyte video
Current videos and an opportunity to expand the kidney library
The GlobalRPh video library currently has a small Nephrology & Electrolytes section. The portal surfaces those videos and identifies modern GFR/CKD topics that would be useful additions.
Full library
Planned GlobalRPh updates
Areas we’re continuing to improve in the Nephrology library
GlobalRPh’s kidney-function and renal-dosing calculators have been widely used for many years, but nephrology has changed substantially across eGFR equations, cystatin C, albuminuria, kidney-failure prediction, CKD pharmacotherapy, anemia, glomerular disease and dialysis care. We plan to preserve the useful dosing workflows while updating the clinical framework around them.
Pages we plan to refresh
- CKD-EPI calculator: this is our highest-priority nephrology calculator update. The current GlobalRPh page uses the 2009 equation and a Black-race coefficient. We plan to replace it with the race-free 2021 CKD-EPI creatinine equation plus cystatin-C and combined creatinine-cystatin C options.
- MDRD calculator: we plan to preserve it only as a historical equation and make the current race-free CKD-EPI pathway the primary adult CKD-staging tool.
- Pediatric creatinine-clearance calculator: the current page contains Bedside Schwartz plus several much older equations. We plan to add contemporary CKiD U25 creatinine and cystatin-C estimation for children, adolescents and young adults while clearly separating drug dosing from eGFR staging.
- Adult creatinine-clearance tools: we plan to clarify body-weight selection, obesity, low muscle mass, low serum creatinine, older adults, amputations and the distinction between Cockcroft-Gault CrCl and BSA-indexed eGFR.
- Salazar-Corcoran: we plan to retain this historical obesity equation for comparison while making current drug-specific renal-function guidance more prominent.
- Unstable renal-function Multi-Calc: we plan to re-review the Jelliffe, Brater and Chiou equations, define the situations in which they remain useful and emphasize their limitations relative to direct clinical assessment in AKI.
- Proteinuria calculator: we plan to preserve the gender-specific protein:creatinine equation while adding a modern uACR pathway, CKD albuminuria categories, transient albuminuria cautions and treatment-response interpretation.
- Kidney-failure risk: we plan to add a validated Kidney Failure Risk Equation tool because KDIGO 2024 recommends externally validated kidney-failure risk estimation in CKD G3–G5.
- Urinary indices / FE-Na: we plan to clarify diuretic limitations, nonoliguric AKI, sepsis, CKD and the situations in which urine indices cannot reliably distinguish intrinsic from prerenal kidney injury.
- Renal Dosing Database: this is a major long-term update project. The current alphabetical database still includes obsolete/discontinued medications and older renal thresholds. We plan to verify currently marketed drugs against current labeling and add clearer dialysis, CRRT and renal-function-method information.
- Renal Failure Agents: we plan to rebuild the older phosphate-binder / renal-failure page around current CKD-MBD therapy, remove outdated calcium-phosphate-product thresholds and modernize binder, calcimimetic and vitamin-D therapy.
- Vitamin D Analogs: the current page contains older supplementation targets and historical claims. We plan to separate general vitamin-D supplementation from CKD-MBD treatment and align kidney-specific use with current KDIGO guidance.
- Anemia / iron: we plan to update GlobalRPh iron-deficit and IV iron pages against the 2026 KDIGO Anemia in CKD guideline, current products, iron indices, ESA/HIF-PHI context where applicable and dialysis-specific treatment.
- CKD treatment hub: we plan to build a permanent kidney-protection page around albuminuria, RAS inhibition, SGLT2 inhibitors, nonsteroidal mineralocorticoid-receptor antagonism, GLP-1 therapy, blood pressure, statins, metabolic health and medication stewardship.
- Glomerular disease: we plan to add GlobalRPh clinical pages for IgA nephropathy, lupus nephritis, ANCA-associated vasculitis, nephrotic syndrome and ADPKD instead of relying primarily on external guideline links.
- Dialysis & transplant: we plan to create a clearer advanced-CKD center covering renal-replacement options, conservative kidney management, vascular access, dialysis medication dosing, transplant evaluation and immunosuppressant monitoring.
Current external clinical guidance
Primary kidney-disease guideline and equation resources
Supporting GlobalRPh resources
Related clinical portals, laboratory tools and directories
Cardiorenal / metabolic crossover
Hospital / medication support
Laboratory & directories
Why GlobalRPh keeps both creatinine-clearance and eGFR resources
Nephrology and medication dosing ask related but not identical questions. GlobalRPh will continue to support Cockcroft-Gault and other creatinine-clearance workflows where medication labeling or pharmacokinetic practice requires them, while modernizing CKD staging and risk assessment around race-free eGFR, cystatin C, albuminuria and validated kidney-failure prediction.
Common LAB Values Renal Dosing
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