Electrolytes, Fluids & Acid-Base Resource Center
Sodium and water-balance calculators, potassium assessment and replacement tools, magnesium dosing and supplement calculators, calcium and phosphate resources, acid-base equations, IV electrolyte dilution guidance, renal indices, and related GlobalRPh clinical articles.
Clinical background
Electrolyte values are interconnected with water balance, kidney function and acid-base physiology
Sodium, potassium, magnesium, calcium, phosphate, chloride and bicarbonate are often discussed separately, but clinically they interact continuously. Serum concentration may reflect true depletion or excess, a shift between compartments, altered water balance, changes in pH, renal handling, medication effects, endocrine physiology, or a combination of these factors.
The purpose of this portal is to bring GlobalRPh's electrolyte calculations, drug tables, IV dilution references, renal tools, and newer dosing resources into one location. The calculators can support a clinical assessment, but replacement or correction plans still require serial laboratory data, symptoms, ECG findings when relevant, kidney function, ongoing losses, medications, infusion route, and the anticipated rate of change.
- Hyponatremia & hypernatremia
- Hypokalemia & hyperkalemia
- Magnesium replacement
- Calcium / albumin / ionized calcium
- Phosphate replacement
- Acid-base interpretation
- Osmolality & osmolarity
- IV electrolyte preparation
Magnesium Supplement Multi-Calculator
GlobalRPh has expanded the Electrolytes library with molecular-weight and elemental-magnesium tools covering multiple commonly used magnesium salts. The multi-calculator is the fastest starting point when comparing formulations or estimating the amount of a selected magnesium compound needed to provide a target elemental-magnesium amount.
Custom Hypertonic Saline 3% & 0.9% NS Calculator
This GlobalRPh calculator was created after clinical feedback requesting greater flexibility in entering starting sodium, desired sodium, body weight, sex, saline concentration and correction-rate assumptions. Because sodium correction can cause serious neurologic harm when misapplied, calculated results require close clinical and laboratory monitoring.
Sodium & water balance
Hyponatremia, hypernatremia, free water and osmolality
Sodium concentration must be interpreted alongside volume status, tonicity, glucose, urine data, renal function, medications, chronicity and neurologic symptoms. The tools below address different parts of that assessment rather than serving as interchangeable sodium calculators.
Hyponatremia correction tools
Hypernatremia & water balance
Sodium interpretation & renal handling
Potassium
Deficit estimation, replacement, renal handling and diagnostic support
The current Electrolytes page already contains several potassium tools; additional potassium diagnostic and total-body resources located elsewhere on GlobalRPh are now included here.
Hypokalemia replacement
Diagnostic / renal potassium tools
Magnesium
Hospital replacement plus the expanded magnesium-supplement calculator suite
Magnesium is one of the most expanded areas in the current GlobalRPh electrolyte library. The newer formulation-specific tools are now separated from the hospital replacement calculator so users can immediately distinguish clinical repletion from oral supplement conversion.
Clinical replacement & IV use
Magnesium formulation calculators
Magnesium articles & education
Calcium & vitamin D
Corrected calcium, hypocalcemia therapy and calcium supplementation
Calcium assessment
Calcium & vitamin D intake
IV calcium preparation
Phosphate
Hypophosphatemia dosing, product selection and IV preparation
IV phosphate
Related mineral balance
Acid-base, osmolality & fluid calculations
Interpreting electrolyte disorders in physiologic context
Acid-base
Osmolality & fluid distribution
IV electrolyte preparation
Direct links to the GlobalRPh dilution library
The older Electrolytes page placed these important preparation references in one compressed text line. They are now separated and made prominent because concentration, dilution, route and infusion details are central to safe parenteral electrolyte administration.
Calcium & magnesium
Potassium, phosphate & sodium
GlobalRPh electrolyte-related reading
Magnesium, sodium, potassium and kidney-related articles
The previous page displayed only one article. The revised portal now surfaces additional electrolyte-focused GlobalRPh material from the Internal Medicine, Nephrology, Cardiology, Nutrition and clinical-calculator archives.
Video
GlobalRPh electrolyte video
Potassium deficit and hypokalemia
Planned GlobalRPh updates
Areas we’re continuing to improve in the Electrolytes library
Many of these tools have served GlobalRPh users for years, while newer magnesium and potassium resources have been added more recently. As we work through this section, we plan to update older reference sets, strengthen safety language, consolidate overlapping calculators where appropriate, and make the relationship between the equations and current bedside practice clearer.
Pages we plan to refresh
- Hyponatremia and hypertonic-saline tools: we plan to re-review correction limits, acute versus chronic presentations, bolus versus continuous strategies, monitoring intervals, overcorrection rescue concepts and the way the calculators explain their assumptions.
- Review of Hyponatremia: we plan to turn the older reference page into a current clinical overview that separates hypotonic hyponatremia, pseudohyponatremia, hyperglycemia-related changes, SIADH, hypovolemia, hypervolemia and urgent neurologic presentations.
- Hypocalcemia Treatment Calculator: this is a high-priority update. The current page is still labeled “BETA” and includes older references such as the 2005 AHA electrolyte guidance. We plan to update the diagnostic framework, ionized-calcium discussion, IV calcium use, magnesium/phosphate interactions and references.
- Corrected Calcium Calculator: we plan to strengthen the distinction between albumin-corrected total calcium and directly measured ionized calcium, especially in critical illness and significant albumin or pH abnormalities.
- Magnesium Dosing / Magnesium Supplements: the newer formulation calculators are much more current than the older replacement table. We plan to integrate the best material into a clearer hospital-versus-supplement workflow and re-check renal dosing and infusion language.
- Potassium Supplements / Hyperkalemia section: we plan to update the older hyperkalemia treatment material, modern potassium-binder context, monitoring language, renal considerations and references.
- Potassium deficit and replacement calculators: we plan to make the limitations of total-body deficit estimation more prominent and better connect replacement estimates with renal function, magnesium status, ECG findings and ongoing losses.
- TTKG and urinary potassium tools: we plan to clarify when these renal indices are useful, their assumptions and where contemporary nephrology practice favors alternative diagnostic approaches.
- Phosphate Dosing: we plan to update IV and oral replacement thresholds, potassium-versus-sodium phosphate selection, renal adjustment, calcium-phosphate considerations and monitoring language.
- Osmolarity calculators: we plan to further distinguish peripheral-IV osmolarity assessment from TPN and general compounding calculations and keep the electrolyte concentration database synchronized with the Compounding portal.
- IV electrolyte dilution pages: we plan to verify product concentrations, preparation language, infusion-rate limits, compatibility notes and current labeling across calcium, magnesium, potassium, phosphate, bicarbonate and hypertonic saline.
Current verification resources
Use current labeling and kidney guidance alongside the calculators
Supporting GlobalRPh resources
