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Pharmacokinetics Portal

 

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Pharmacokinetic Calculators


Dosing by levels


Clearance Equations

     


A new beta multi-calc was created with specialized handling of patients with a height below 60 inches. It also contains all of the functionality of the standard multi-calculator as well as the calculation of the GFR Creatinine Clearance / GFR- Multi-calc (height adjustment)


Cytochrome P450 Analysis Tool   


Pharmacokinetics

   


Trough Calculators

 


——— This new program can be used to determine when to administer the next dose of vancomycin after a supratherapeutic trough is obtained. An estimated elimination rate constant is generated from the creatinine clearance which is then used to determine the timing of the next dose based on the desired target trough concentration.

 


——— Use this program if the vancomcyin level is drawn early and you want to estimate the actual trough just before the next dose to determine if the current regimen is appropriate

 


Vancomycin – Single-level dosing

Vancomycin SINGLE Level-(dosing by levels) Original calc Led


If you would like to enter the time since the last dose was given, use this version.This new version may be especially useful if the trough was drawn late and the next dose was delayed. Example: current regimen vanco 1 gram q12h. Trough was drawn 12.5 hours after the last dose.

Vancomycin single-level – dose infused early or late


The GlobalRPh vancomycin single-level calculator uses the Vd recommended in Bauer’s text: 0.7 L/kg. Use the advanced version if you wish to manipulate this value.

Vancomycin single level – Advanced version


Video Section

Vancomycin Dosing & Monitoring


 

Drug Tables  and Latest Articles

Cardiology

Aminoglycosides /Vancomycin Empiric Dosing

Aminoglycosides/ Vancomycin Calculator (Original calculator) Advanced Aminoglycoside – Vancomycin Multiple ke calculator Advanced Pharmacokinetic Dosing

Dosing By Levels

Dosing by levels (Full) – Enter two levels and associated times Dosing by levels(quick) – Enter two levels and the time between levels Dosing by levels(SINGLE) – Vancomycin -single level analysis Hot
——– Non-Steady State kinetics ——–

Heparin Dosing

Heparin Dosing Heparin Dosing- MC Dallas Hosp Heparin Dosing- Affinity Medical
Heparin Dosing – Detroit VAMC

Other

APACHE II calculator Digoxin Dosing Calc Phenytoin Dosing Calc
Renal Dosing Protocols Warfarin Dosing Calc
A warfarin maintenance adjustment tool was created. This new tool has a built-in database of warfarin maintenance regimens from 5 to 100mg.

Drug Tables / Other

Clinical concerns- Geriatric patient Drug-Food Interactions Drug- Grapefruit Interactions
Ideal body weight (IBW) AND Adjusted body weight calc Pharmacokinetics – Review Cytochrome P450 Analysis Tool
First order kinetics equation derivation Therapeutic Drug Levels

Pharmacokinetics

Vancomycin: Based on input from one of our visitors (below), a new vancomycin program was created. This new program can be used to determine when to administer the next dose of vancomycin after a supratherapeutic trough is obtained. An estimated elimination rate constant is generated from the creatinine clearance which is then used to determine the timing of the next dose based on the desired target trough concentration.Another version of this program was created to generate an estimated vancomycin kel value based on the creatinine clearance. Use this program if the vancomcyin level is drawn early and you want to estimate the actual trough just before the next dose to determine if the current regimen is appropriate – link to new program..) Trough calculator: The following trough calculator used to predict the actual trough value if the level is drawn early.

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Pharmacokinetics


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Common LAB Values  Renal Dosing