Psoriasis Risk In Children With High BMI Overview This study aimed to investigate the potential association between childhood body mass index (BMI) and the risk of psoriasis. Using publicly available summary statistics from genome-wide association studies (GWAS) that focused on childhood BMI in individuals of European descent (n=39,620), the researchers conducted a
Author: Nancy Ogbonna
Perforator Flaps For Patellar Defects
Perforator Flaps For Patellar Defects Overview This study explores the use of pedicled fascio-cutaneous perforator flaps, specifically the descending genicular artery perforator (DGAP) flap, for reconstructing complex peripatellar defects. While free flaps and pedicled muscle flaps are more commonly employed for this purpose, the DGAP flap is presented as a viable and
Cataract Repair: 20-Year Outcomes In Diabetic Patients
Cataract Repair: 20-Year Outcomes In Diabetic Patients Overview This study aimed to assess the 20-year outcomes in terms of best-corrected visual acuity (BCVA) and subjective visual function, as measured by the VF-14 questionnaire, following cataract surgery in individuals with type 2 diabetes compared to those without diabetes. A prospective, longitudinal, population-based cohort study
Obesity Treatment With Tirzepatide And Semaglutide
Obesity Treatment With Tirzepatide And Semaglutide Overview The aim of this study was to compare the effectiveness of obesity treatment with tirzepatide at doses of 10 mg and 15 mg with semaglutide at a dose of 2.4. The comparison was conducted using an indirect treatment comparison method. The study utilized data from the
Hydroxyurea: Pediatric Use in Sickle Cell Anemia
Hydroxyurea: Pediatric Use in Sickle Cell Anemia Overview This retrospective cohort study aimed to investigate the relationship between adherence to hydroxyurea treatment and clinical outcomes in children and adolescents with sickle cell anemia (SCA). The study utilized Medicaid data spanning from 2005 to 2012 across several U.S. states, focusing on children aged
HIV Treatment And Long-Acting Therapy Preferences
HIV Treatment And Long-Acting Therapy Preferences Overview Recent developments in long-acting antiretroviral therapy (LA-ART) offer promising prospects for enhancing HIV treatment by addressing adherence challenges. However, the success of these regimens depends on their acceptance among people living with HIV (PWH). To investigate patient preferences regarding LA-ART options, we conducted a discrete
Ganaxolone Treatment For Refractory Epilepsy
Ganaxolone Treatment For Refractory Epilepsy Overview In a meta-analysis conducted to evaluate the use of ganaxolone for refractory epilepsy, researchers collected data from four randomized controlled trials involving a total of 659 patients. The analysis revealed that ganaxolone significantly improved the reduction in mean seizure frequency by ≥50% when compared to a
Insulin Therapy for Wound Healing: A Meta-Analysis
Insulin Therapy for Wound Healing: A Meta-Analysis Overview Insulin, known for its affordability and widespread availability, has emerged as a promising agent in the realm of wound healing. This study delved into the potential of local insulin administration to facilitate the recovery of damaged skin among non-diabetic adults. To achieve this, a
PD-1/L1 Inhibitors: Treatment Efficacy In Urothelial Carcinoma
PD-1/L1 Inhibitors: Treatment Efficacy In Urothelial Carcinoma Overview Programmed cell death‐1/ligand 1 (PD-1/PD-L1) inhibitors represent a novel therapeutic approach for advanced urothelial carcinoma, prompting the need for a comparative assessment of their effectiveness and safety in comparison to traditional chemotherapy. To address this, a comprehensive meta-analysis of randomized controlled trials conducted until
Skin Lightening: Topical Approaches To Treatment
Skin Lightening: Topical Approaches To Treatment Overview The recent removal of hydroquinone from over-the-counter skin lightening products has created a demand for modern formulations that effectively address skin pigmentation issues. A successful skin lightening formulation should be non-irritating to prevent post-inflammatory hyperpigmentation, penetrate effectively to reach the epidermal/dermal junction, incorporate anti-inflammatory ingredients,
