Ganaxolone Treatment For Refractory Epilepsy Overview In a meta-analysis conducted to evaluate the use of ganaxolone for refractory epilepsy, researchers collected data from four randomized controlled trials involving a total of 659 patients. The analysis revealed that ganaxolone significantly improved the reduction in mean seizure frequency by ≥50% when compared to a
Family Practice Medicine
Osteoarthritis Unveiled: Advanced Treatments for Joint Pain
Patient Education This article is tailored for patients. Refer your patients to this article for them to learn more about their condition. Osteoarthritis Unveiled: Advanced Treatments for Joint Pain Osteoarthritis is a common form of arthritis that affects joints in the body. While it is incurable, there are various treatment options available
Cabozantinib Therapy In Hepatocellular Carcinoma
Cabozantinib Therapy In Hepatocellular Carcinoma Hepatocellular carcinoma (HCC) is a predominant form of liver cancer, accounting for approximately 90% of cases. Unfortunately, it carries a grim prognosis, with a median survival rate ranging from 6 to 18 months. Historically, sorafenib had been the established first-line therapy for HCC. However, in recent
Obese Children And Related Skin Conditions
Obese Children And Related Skin Conditions The World Health Organization defines overweight and obesity based on the body mass index (BMI), which is calculated as weight (kg) divided by height (m2). When assessing overweight and obesity in children, it's important to consider their age and gender. To do this, percentile curves
Encapsulated Papillary Carcinoma Membrane Characteristics
Encapsulated Papillary Carcinoma Membrane Characteristics Overview This study focused on encapsulated papillary carcinoma (EPC), a type of breast carcinoma characterized by a thick fibrous capsule-like structure surrounding the tumor, often interpreted as a thickened basement membrane (BM). The primary objective was to investigate the geometric properties of the EPC capsule and determine
Ibrutinib Treatment In Waldenström Macroglobulinemia
Ibrutinib Treatment In Waldenström Macroglobulinemia Waldenström macroglobulinemia (WM) is a rare type of non-hogdkins lymphoma driven by the gene mutation MYD88L265P. Ibrutinib, the first approved treatment, is effective but can cause side effects. A study found that 27% of WM patients needed to reduce Ibrutinib doses due to side effects like
Stomach Cancer: A Meta-Analysis Of Robotic Surgery Complications
Stomach Cancer: A Meta-Analysis Of Robotic Surgery Complications Gastric or stomach cancer prevalence varies significantly around the world, with higher rates in Asia, Africa, South America, and Eastern Europe. However, in the United States, stomach cancer is a growing concern due to its increased occurrence in the elderly population and its
Cognitive Behavioral Therapy In Patients With Insomnia And Chronic Fatigue
Cognitive Behavioral Therapy In Patients With Insomnia And Chronic Fatigue Overview This study delves into the relationship between insomnia, chronic fatigue, and the response to cognitive behavioral therapy for insomnia (CBT-I). The research, a secondary analysis of data from a community-based randomized controlled trial, encompassed 1717 participants with self-reported insomnia. The primary
Control of Allergic Rhinitis and Asthma Test: A COSMIN Analysis
Control of Allergic Rhinitis and Asthma Test: A COSMIN Analysis Overview The Control of Allergic Rhinitis and Asthma Test (CARAT) serves as a patient-reported outcome measurement (PROM) to evaluate the management of asthma and allergic rhinitis (AR) within a 4-week timeframe. This systematic review aimed to assess CARAT's measurement properties. Adhering to
Ciclopirox Hydrolacquer Therapy For Adult Onychomycosis
Ciclopirox Hydrolacquer Therapy For Adult Onychomycosis Overview In a Phase III trial, a water-soluble ciclopirox nail hydrolacquer was evaluated for treating toenail fungal infection. Its enhanced penetration delivered higher ciclopirox concentration to the nail compared to existing lacquers. The study compared the hydrolacquer, its base formulation (vehicle), and an active control over
