Alzheimer's Patients and Low Tau Burden Outcomes Overview The study focuses on individuals within the Alzheimer's Disease (AD) pathway exhibiting abnormal amyloid-beta (Aβ) and tau deposition. Specifically, it investigates a subgroup characterized by low tau levels (A+T−) and compares them to their counterparts with higher tau levels (A+T+). The research involves 397 individuals
Aging in Place
White Matter Brain Changes In Post-Chemotherapy Breast Cancer Patients
White Matter Brain Changes In Post-Chemotherapy Breast Cancer Patients Overview In this study, the objective was to evaluate white matter microstructural changes in older breast cancer survivors 5-15 years post-chemotherapy treatment. The participants included breast cancer survivors aged 65 or older who underwent chemotherapy (C+) and those who did not (C-), along
Multimorbidity In Patients With Cognitive Impairment And Dementia
Multimorbidity In Patients With Cognitive Impairment And Dementia Overview The study aimed to investigate the burden and clusters of multimorbidity in relation to mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD)-related plasma biomarkers among older adults. A population-based sample of 5432 participants aged 60 years and above was included, with a
Anticholinergic Medications And Cognitive Outcomes In Autistic Adults
Anticholinergic Medications And Cognitive Outcomes In Autistic Adults Overview This study investigates the impact of anticholinergic (AC) medications on cognitive outcomes in autistic adults, an area that has not been extensively researched. AC medications, known for their potential to cause cognitive impairment, are commonly used for various medical and psychiatric conditions. In
Myasthenia Gravis Therapeutic Benefits Of Monotherapy With Tacrolimus
Myasthenia Gravis Therapeutic Benefits Of Monotherapy With Tacrolimus Overview In the management of mild to moderate myasthenia gravis (MG), the utilization of tacrolimus is typically reserved for cases that do not respond to glucocorticoids. This study sought to assess the potential advantages of mono-tacrolimus over mono-glucocorticoids in treating MG patients. The primary endpoint
Patellofemoral Arthroplasty Designs and Osteoarthritis Progression
Patellofemoral Arthroplasty Designs and Osteoarthritis Progression Overview This study aimed to evaluate clinical and functional outcomes, complication rates, implant survivorship, and the progression of tibiofemoral osteoarthritis (OA) in patients with isolated patellofemoral OA undergoing new inlay or onlay patellofemoral arthroplasty (PFA). The research also sought to compare different implant types and models
Gout in Patients With Inflammatory Bowel Disease
Gout in Patients with Inflammatory Bowel Disease Overview Arthritis is a well-established extra-intestinal manifestation of inflammatory bowel disease (IBD). Recent studies have indicated disruptions in uric acid metabolism among individuals with IBD. This investigation aimed to explore the link between IBD and gout using a comprehensive multi-center database (Explorys Inc.) comprising data
Prostate Cancer Detection Using Urine Glycoproteins
Prostate Cancer Detection Using Urine Glycoproteins Overview In a recent study, researchers investigated the potential of using pre-digital rectal examination (DRE) urine specimens to detect aggressive prostate cancer (AG-PCa) by comparing glycoproteins found in pre- and post-DRE urine samples. The study involved 154 pre-DRE urine specimens from individuals with no cancer at
Lithium Effects On Renal Function In Geriatric Patients
Lithium Effects On Renal Function In Geriatric Patients Overview The practice of augmenting antidepressant therapy with lithium, known as Lithium Augmentation (LA), is considered a primary treatment option for individuals suffering from Treatment-Resistant Depression (TRD). However, in the case of geriatric patients, this approach is notably underutilized due to concerns surrounding potential
Azelaic Acid Treatment For Rosacea and Melasma
Azelaic Acid Treatment For Rosacea and Melasma Overview This study evaluated the effectiveness and safety of topical azelaic acid (AA) for various dermatological conditions, including acne vulgaris, rosacea, hyperpigmentation/melasma, and skin aging. The researchers conducted a systematic review of randomized controlled trials (RCTs) with a minimum treatment duration of 6 weeks, searching
