Alzheimer's Patients and Low Tau Burden Outcomes Overview The study focuses on individuals within the Alzheimer's Disease (AD) pathway exhibiting abnormal amyloid-beta (Aβ) and tau deposition. Specifically, it investigates a subgroup characterized by low tau levels (A+T−) and compares them to their counterparts with higher tau levels (A+T+). The research involves 397 individuals
Neurology
White Matter Brain Changes In Post-Chemotherapy Breast Cancer Patients
White Matter Brain Changes In Post-Chemotherapy Breast Cancer Patients Overview In this study, the objective was to evaluate white matter microstructural changes in older breast cancer survivors 5-15 years post-chemotherapy treatment. The participants included breast cancer survivors aged 65 or older who underwent chemotherapy (C+) and those who did not (C-), along
Multimorbidity In Patients With Cognitive Impairment And Dementia
Multimorbidity In Patients With Cognitive Impairment And Dementia Overview The study aimed to investigate the burden and clusters of multimorbidity in relation to mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD)-related plasma biomarkers among older adults. A population-based sample of 5432 participants aged 60 years and above was included, with a
Anticholinergic Medications And Cognitive Outcomes In Autistic Adults
Anticholinergic Medications And Cognitive Outcomes In Autistic Adults Overview This study investigates the impact of anticholinergic (AC) medications on cognitive outcomes in autistic adults, an area that has not been extensively researched. AC medications, known for their potential to cause cognitive impairment, are commonly used for various medical and psychiatric conditions. In
Radiosurgery Timing In Brain Cancer Patients
Radiosurgery Timing In Brain Cancer Patients Metastatic brain cancer, also known as brain metastases, occurs when cancer cells from a primary tumor elsewhere in the body spread to the brain. Metastatic brain cancer represents an advanced stage of cancer, indicating that cancer cells have already spread from their original site to
Seizure Therapy And White Matter Changes
Seizure Therapy And White Matter Changes Functional seizures (FS) are a type of functional neurological symptom disorder that mimics epileptic seizures but lacks epileptiform changes on electroencephalography. The neuropathophysiology involves various brain systems, such as sensorimotor, emotion regulation, cognitive control, and multimodal integration. Neurobehavioral therapy (NBT) has emerged as a viable treatment
Concussion Symptom Treatment Using Acoustic Stimulation
Concussion Symptom Treatment Using Acoustic Stimulation In the U.S. military, over 370,000 service members have had mild traumatic brain injuries (mTBI) or concussions since 2000, possibly more due to underreporting. While most recover within 7–30 days, about 15% face persistent postconcussive symptoms (PPCS) for at least 3 months. Despite the end
Narcissistic Personality Disorder And Autism
Narcissistic Personality Disorder And Autism Overview This study explores the relationship between Autism Spectrum Disorders (ASD) and Narcissistic Personality Disorder (NPD), focusing on the dimensions of narcissistic vulnerability and grandiosity. Both ASD and NPD pose challenges in diagnosis due to shared characteristics, such as pervasive traits, lifelong duration, ego-syntonic features, and difficulties
Sleep Stage Moderation Using Automated Auditory Stimulation
Sleep Stage Moderation Using Automated Auditory Stimulation Overview The study introduces a pioneering protocol for the automated detection and suppression of slow-wave sleep (SWS), a crucial physiological process with implications for both basic science and clinical applications. The protocol involves the automated identification of SWS through the entire head topography of frontal
Myasthenia Gravis Therapeutic Benefits Of Monotherapy With Tacrolimus
Myasthenia Gravis Therapeutic Benefits Of Monotherapy With Tacrolimus Overview In the management of mild to moderate myasthenia gravis (MG), the utilization of tacrolimus is typically reserved for cases that do not respond to glucocorticoids. This study sought to assess the potential advantages of mono-tacrolimus over mono-glucocorticoids in treating MG patients. The primary endpoint
