Myasthenia Gravis Therapeutic Benefits Of Monotherapy With Tacrolimus Overview In the management of mild to moderate myasthenia gravis (MG), the utilization of tacrolimus is typically reserved for cases that do not respond to glucocorticoids. This study sought to assess the potential advantages of mono-tacrolimus over mono-glucocorticoids in treating MG patients. The primary endpoint
Internal Medicine
Weight Loss In Diabetic Patients After Bariatric Surgery
Weight Loss In Diabetic Patients After Bariatric Surgery In recent decades, obesity and its repercussions have posed a significant healthcare challenge. Back in 2015–2016, almost 39.8% of US adults were grappling with obesity, and projections suggest a potential surge to 51% by 2030. The economic toll of obesity-related comorbidities is substantial,
Knee Osteoarthritis Improvements Using Telehealth Exercise Programs
Knee Osteoarthritis Improvements Using Telehealth Exercise Programs Overview This study aimed to investigate the factors that mediate the impact of two 6-month telehealth-delivered exercise programs, with and without a weight-loss diet, on pain and function improvements in individuals with knee osteoarthritis (OA). The secondary analysis involved 345 participants from a 3-arm randomized
Bariatric Surgery In Hypertrophic Cardiomyopathy Patients
Bariatric Surgery In Hypertrophic Cardiomyopathy Patients Overview Existing research has hinted at a link between obesity and increased risk of acute cardiovascular events. Bariatric surgery has been shown to mitigate this risk; however, its impact on patients with both obesity and hypertrophic cardiomyopathy (HCM) remains unclear. This study aimed to assess whether
Mepolizumab Effectiveness In Asthma, Rhinosinusitis, and Sinus Surgery Patients
Mepolizumab Effectiveness In Asthma, Rhinosinusitis, and Sinus Surgery Patients Overview In this retrospective cohort study utilizing IQVIA PharMetrics Plus claims data, the effectiveness of mepolizumab, a humanized anti-interleukin 5 monoclonal antibody, was explored in a real-world setting for U.S. patients with severe asthma and comorbid chronic rhinosinusitis (CRS) with or without sinus
Patellofemoral Arthroplasty Designs and Osteoarthritis Progression
Patellofemoral Arthroplasty Designs and Osteoarthritis Progression Overview This study aimed to evaluate clinical and functional outcomes, complication rates, implant survivorship, and the progression of tibiofemoral osteoarthritis (OA) in patients with isolated patellofemoral OA undergoing new inlay or onlay patellofemoral arthroplasty (PFA). The research also sought to compare different implant types and models
Music Therapy For Dementia Symptoms Treatment
Music Therapy For Dementia Symptoms Treatment Overview The study explores the impact of individualized music listening (IML) on the behavioral and psychological symptoms of dementia (BPSD), a topic previously assessed through proxy-completed questionnaires. To address methodological limitations, the researchers employed a systematic observational approach, incorporating a validated instrument, time-based sampling, and longitudinal
Transfusion-Dependent Thalassemia: Iron Overload And Organ Dysfunction
Transfusion-Dependent Thalassemia: Iron Overload And Organ Dysfunction Transfusion-dependent thalassemia (TDT) is an inherited blood disorder found most often in the Middle East and Africa. In places like Iran, beta-thalassemia, a more common type, has major and minor subtypes. The severe form, called Cooley's anemia, lacks beta protein in hemoglobin, making regular
Cognitive Behavioral Therapy: Telehealth Effectiveness For Chronic Mental Disorders
Cognitive Behavioral Therapy: Telehealth Effectiveness For Chronic Mental Disorders Overview Amidst the pandemic, the adoption of remote treatments, specifically telephone-delivered cognitive behavioral therapy (T-CBT), has witnessed a notable increase. This meta-analysis seeks to fill a gap in existing literature by evaluating the effectiveness of T-CBT in chronic and/or mental illnesses, comparing it
Gout in Patients With Inflammatory Bowel Disease
Gout in Patients with Inflammatory Bowel Disease Overview Arthritis is a well-established extra-intestinal manifestation of inflammatory bowel disease (IBD). Recent studies have indicated disruptions in uric acid metabolism among individuals with IBD. This investigation aimed to explore the link between IBD and gout using a comprehensive multi-center database (Explorys Inc.) comprising data
