Multimorbidity In Patients With Cognitive Impairment And Dementia Overview The study aimed to investigate the burden and clusters of multimorbidity in relation to mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD)-related plasma biomarkers among older adults. A population-based sample of 5432 participants aged 60 years and above was included, with a
Aging in Place
Anticholinergic Medications And Cognitive Outcomes In Autistic Adults
Anticholinergic Medications And Cognitive Outcomes In Autistic Adults Overview This study investigates the impact of anticholinergic (AC) medications on cognitive outcomes in autistic adults, an area that has not been extensively researched. AC medications, known for their potential to cause cognitive impairment, are commonly used for various medical and psychiatric conditions. In
Myasthenia Gravis Therapeutic Benefits Of Monotherapy With Tacrolimus
Myasthenia Gravis Therapeutic Benefits Of Monotherapy With Tacrolimus Overview In the management of mild to moderate myasthenia gravis (MG), the utilization of tacrolimus is typically reserved for cases that do not respond to glucocorticoids. This study sought to assess the potential advantages of mono-tacrolimus over mono-glucocorticoids in treating MG patients. The primary endpoint
Patellofemoral Arthroplasty Designs and Osteoarthritis Progression
Patellofemoral Arthroplasty Designs and Osteoarthritis Progression Overview This study aimed to evaluate clinical and functional outcomes, complication rates, implant survivorship, and the progression of tibiofemoral osteoarthritis (OA) in patients with isolated patellofemoral OA undergoing new inlay or onlay patellofemoral arthroplasty (PFA). The research also sought to compare different implant types and models
Gout in Patients With Inflammatory Bowel Disease
Gout in Patients with Inflammatory Bowel Disease Overview Arthritis is a well-established extra-intestinal manifestation of inflammatory bowel disease (IBD). Recent studies have indicated disruptions in uric acid metabolism among individuals with IBD. This investigation aimed to explore the link between IBD and gout using a comprehensive multi-center database (Explorys Inc.) comprising data
Prostate Cancer Detection Using Urine Glycoproteins
Prostate Cancer Detection Using Urine Glycoproteins Overview In a recent study, researchers investigated the potential of using pre-digital rectal examination (DRE) urine specimens to detect aggressive prostate cancer (AG-PCa) by comparing glycoproteins found in pre- and post-DRE urine samples. The study involved 154 pre-DRE urine specimens from individuals with no cancer at
Lithium Effects On Renal Function In Geriatric Patients
Lithium Effects On Renal Function In Geriatric Patients Overview The practice of augmenting antidepressant therapy with lithium, known as Lithium Augmentation (LA), is considered a primary treatment option for individuals suffering from Treatment-Resistant Depression (TRD). However, in the case of geriatric patients, this approach is notably underutilized due to concerns surrounding potential
Azelaic Acid Treatment For Rosacea and Melasma
Azelaic Acid Treatment For Rosacea and Melasma Overview This study evaluated the effectiveness and safety of topical azelaic acid (AA) for various dermatological conditions, including acne vulgaris, rosacea, hyperpigmentation/melasma, and skin aging. The researchers conducted a systematic review of randomized controlled trials (RCTs) with a minimum treatment duration of 6 weeks, searching
Rheumatoid Arthritis Work Limitation Factors
Rheumatoid Arthritis Work Limitation Factors Rheumatic and musculoskeletal diseases (RMD) introduce pain and functional limitations into the workplace, affecting individuals with rheumatoid arthritis and osteoarthritis. This study delves into the multifaceted factors that shape the work challenges arising from RMD, acknowledging the broader societal costs involved. By shedding light on these
Cefuroxime Prophylaxis For Cataract Postoperative Endophthalmitis
Cefuroxime Prophylaxis For Cataract Postoperative Endophthalmitis In their meta-analysis, the researchers aimed to evaluate the impact of prophylactic intracameral cefuroxime injection on postoperative endophthalmitis in cataract surgery. They conducted a comprehensive review of the literature up to July 2022, which included a total of 1,167,197 participants who underwent cataract surgery. Out
